Endometrial Cancer Stage IIIC1

Posted by mtstack @mtstack, Sep 6, 2025

Spotting in late April.
Referred to gynecologist after abnormal pap showing atypical glandular cells in June
Ultrasound showed endometrial lining thickened to 19.55mm
Collposcopy, scrape of cervix, and endometrial biopsy resulted in endometrial adenocarcinoma FIGO grade 3
Gynecologic consult Aug 4
Complete hysterectomy bilateral salpingo oopherectomy Aug 8
Pathology report: tumor in uterus, 97% invasion of myometrial lining, cancer cells in right sentinel pelvic lymphnode Stage IIIC1
Consult Sep 2: oncologist recommended platinum systemic therapy of six cycles of carboplatin and paclitaxel. Oncologist doesn’t recommend EBRT even though tumor board recommended a referral.

Anyone familiar with this stage and chemo treatment who might be able to share information on side effects. The more I read about chemo, the more I’m afraid to weaken my immune system. Seems like recurrence is likely and wondering about no further treatment?

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

genaf | @genaf | Oct 19, 2025

In reply to @jchantler "@bocabird They make mitts and booties with freezeable inserts. I used them but still got neuropathy" + (show)

@jchantler I've been using Curcunin Phytosome supplements from "Thorne" and it's helping me.

genaf | @genaf | Oct 19, 2025

In reply to @aardvark2118 "I had similar diagnosis to yours. Had chemo and was well prepared by my oncology team..." + (show)

@aardvark2118 I am so impressed that you managed to work. Amazing.

belle4 | @belle4 | Oct 19, 2025

In reply to @naturegirl5 "@belle4 The unknown is often really difficult for most people. That unknown creates so much ambiguity..." + (show)

@naturegirl5 got through my first treatment. Had about 72 hours of bone aches, fatigue, was manageable. No nausea so very grateful. Week 2 I feel real good!! Enjoying this time to gain strength for treatment 2. Feeling much more confident and prepared. I made a list of side effects and how I managed them for easy reference. Hugs to all the ladies that are in the midst of treatment. Be strong!! Thank you for your encouragement.

jchantler | @jchantler | Oct 19, 2025

In reply to @mtstack "@juliea55 You are truly an inspiration. I feel petty complaining about everything. Spoke with a good..." + (show)

@mtstack It's a challenge to stay upbeat. Just switched to Enertu, slept two days night and day, threw up, nausea, weak. YUCK. But after first treatment my CA 125 score went from 599 to 400 something.

mtstack | @mtstack | Oct 19, 2025

In reply to @jchantler "@mtstack It's a challenge to stay upbeat. Just switched to Enertu, slept two days night and..." + (show)

@jchantler
I'm so sorry to hear of your fatigue and nausea which I'm sure makes you feel even worse.
Glad the CA 125 number improved to justify the new drug.

mtstack | @mtstack | Oct 19, 2025

In reply to @genaf "@aardvark2118 I am so impressed that you managed to work. Amazing." + (show)

@genaf
Totally agree. All last week after my first treatment, I wondered how I would have ever managed standing all day at work.

Helen, Volunteer Mentor | @naturegirl5 | Oct 19, 2025

In reply to @belle4 "@naturegirl5 got through my first treatment. Had about 72 hours of bone aches, fatigue, was manageable...." + (show)

@belle4 Great! Making that list of side effects is a good idea. You can discuss those with your oncologist and I hope use your list as a reference for our ladies here on Mayo Clinic Connect.

ffr | @ffr | Oct 20, 2025

In reply to @bettydee "@mtstack I think of cancer cells like this. They’re like the ant hill you see on..." + (show)

@bettydee
This is a great way to think about it! Let me add that my cancer was chemo resistant (metastasis while undergoing treatment) so if there was a chemo drug that would attack my unusual ants I would be happy to partake.