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Endometrial Cancer Stage IIIC1

Posted by mtstack @mtstack, Sep 6, 2025

Spotting in late April.
Referred to gynecologist after abnormal pap showing atypical glandular cells in June
Ultrasound showed endometrial lining thickened to 19.55mm
Collposcopy, scrape of cervix, and endometrial biopsy resulted in endometrial adenocarcinoma FIGO grade 3
Gynecologic consult Aug 4
Complete hysterectomy bilateral salpingo oopherectomy Aug 8
Pathology report: tumor in uterus, 97% invasion of myometrial lining, cancer cells in right sentinel pelvic lymphnode Stage IIIC1
Consult Sep 2: oncologist recommended platinum systemic therapy of six cycles of carboplatin and paclitaxel. Oncologist doesn’t recommend EBRT even though tumor board recommended a referral.

Anyone familiar with this stage and chemo treatment who might be able to share information on side effects. The more I read about chemo, the more I’m afraid to weaken my immune system. Seems like recurrence is likely and wondering about no further treatment?

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ffr | @ffr | Jan 29 8:23pm
In reply to @mtstack "@ffr My cancer has also been chemo resistant. Just after the 4th infusion I experienced spotting..." + (show)
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@ffr
My cancer has also been chemo resistant. Just after the 4th infusion I experienced spotting and a tumor was found in the vaginal cuff just before Christmas. My last two infusions were cancelled. PET scan revealed metastases to lungs, pelvic and pubic bones, lymph nodes and other areas.

Started keytruda and lenvima today. Meeting with radiation oncologist tomorrow to discuss PET scan and MRI of spine to see if radiation would help treat lumbar and hip pain which started two weeks ago, and spotting again for the past week.

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@mtstack
I’m sorry to read your story.
What kind of EC do you have? (If you had shared previously, I cannot find it.) I have clear cell.
My metastasis was found in 2 lymph nodes - pelvic & axillary - between my 5th & final chemo. I had been on a Keytruda trial and was eliminated from that.
Coincidentally, I am having a CT tomorrow. I’ve been having some back pain and wondering if it is another pelvic insufficiency fracture or a recurrence. Or if I’m lucky, just muscular back pain.
The ants go marching one by one…..
I’ll be thinking of you tomorrow and sending positive thoughts. 🤞

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cookercooker | @cookercooker | Jan 30 10:43am
In reply to @mtstack "@ffr My cancer has also been chemo resistant. Just after the 4th infusion I experienced spotting..." + (show)
Profile picture for mtstack @mtstack

@ffr
My cancer has also been chemo resistant. Just after the 4th infusion I experienced spotting and a tumor was found in the vaginal cuff just before Christmas. My last two infusions were cancelled. PET scan revealed metastases to lungs, pelvic and pubic bones, lymph nodes and other areas.

Started keytruda and lenvima today. Meeting with radiation oncologist tomorrow to discuss PET scan and MRI of spine to see if radiation would help treat lumbar and hip pain which started two weeks ago, and spotting again for the past week.

Jump to this post

@mtstack Radiation to ease pain and bleeding should work. It did for me. I am not a good candidate for radiation, since I've already reached my limit. I have the same cancer as you --stage 3C1 (but possibly 2), having serous cell endometrial cancer. Carb/pac combo didn't work very well for it, as four months after the end of the treatment cancer was detected in the vaginal cuff. I felt pain on the left side of pelvic bone, no spotting though. The radiologist gave me a brief blip of EBR and after a week or so, the pain was resolved. Had to switch to Enhertu via a clinical trial. After a year of treatment (every 3 weeks) I'm now am NED. Even so, treatments are ongoing until they prove ineffective. That's the worst part of it.
Hope this helps

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