Endometrial Cancer Stage IIIC1

Posted by mtstack @mtstack, Sep 6, 2025

Spotting in late April.
Referred to gynecologist after abnormal pap showing atypical glandular cells in June
Ultrasound showed endometrial lining thickened to 19.55mm
Collposcopy, scrape of cervix, and endometrial biopsy resulted in endometrial adenocarcinoma FIGO grade 3
Gynecologic consult Aug 4
Complete hysterectomy bilateral salpingo oopherectomy Aug 8
Pathology report: tumor in uterus, 97% invasion of myometrial lining, cancer cells in right sentinel pelvic lymphnode Stage IIIC1
Consult Sep 2: oncologist recommended platinum systemic therapy of six cycles of carboplatin and paclitaxel. Oncologist doesn’t recommend EBRT even though tumor board recommended a referral.

Anyone familiar with this stage and chemo treatment who might be able to share information on side effects. The more I read about chemo, the more I’m afraid to weaken my immune system. Seems like recurrence is likely and wondering about no further treatment?

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

Profile picture for carol1024 @carol1024

@mtstack normal is below 35. Mine at diagnosis was 1641. After 6 treatments was 81. It actually went from 1641 to 744 after 2nd treatment to 179 to 109 then the 81. That was one indicator the chemo was working. Just finished my 2nd second treatment of 2nd session and I'll probably have another CA125 test after 3rd treatment and also another scan.

Jump to this post

@carol1024
Thanks for replying so quickly.
I was surprised that mine was 50 and wondered if it's really necessary to have chemo.
I was told because cancer cells were present in one sentinel lymph node, I should have chemo to kill any cancer cells remaining and lessen chance of recurrence.

REPLY

You are doing all the right things to help your recovery and it sounds you are starting from an otherwise good place health wise. I hope you opt for the chemo. Many of us do not achieve a “cure,” but learn to live a new normal while undergoing periodic treatment. It is not what I would have chosen, but I have learned a lot from my illness. Keep going while you regain your footing. A cure might be just around the corner, but regardless you can have good quality of life. Do everything you can to minimize side effects (ice, ice, ice with cotton gloves) and hopefully you will be good to go!

REPLY
Profile picture for mtstack @mtstack

@carol1024
Thanks for replying so quickly.
I was surprised that mine was 50 and wondered if it's really necessary to have chemo.
I was told because cancer cells were present in one sentinel lymph node, I should have chemo to kill any cancer cells remaining and lessen chance of recurrence.

Jump to this post

@mtstack that is correct because without any intervention it WILL spread and if it's aggressive like mine it will be fast. I thought I had a UTI and then bladder infection. Went to ER when pain was unbearable and scan found cancer. I'd get the chemo and knock it on out before it gets worse. Don't play around with that.

REPLY
Profile picture for juliea55 @juliea55

I understand that about 40 percent of us are allergic to the binder in Taxol (castor oil), and are thereafter switched to Abraxane, which has the same drug but a more natural binder. I wound up in the emergency room overnight, but I consider that lucky, as the Abraxane infusion only takes an hour total (including flushing, etc), instead of the three I understand Taxol takes. That makes it much easier to ice your hands and feet to avoid neuropathy. I was given benydryl and dexamethasone (a steroid) before each infusion, which left me very comfortable. With a high quality diet and exercise, I had very few side effects from chemo and hope you will have the same experience. Good luck!

Jump to this post

@juliea55
Thank you for the information regarding Abraxane.
I mentioned it to the pharmacist yesterday and I think she said that although shorter infusions, it would be more often. I’ll discuss it with the med oncologist as I’d rather not have another allergic reaction to Taxol.

REPLY

I am not a pharmacist, but I am virtually positive that is not the case. The active drug (and presumably amount) in each infusion is the same. The Abraxane takes less time because it does not elicit the same allergic response.

REPLY
Profile picture for mtstack @mtstack

@bocabird
What number do you consider to be low?

Jump to this post

@mtstack The oncologist should be able to tell you relevant to your type of cancer

REPLY
Profile picture for juliea55 @juliea55

You are doing all the right things to help your recovery and it sounds you are starting from an otherwise good place health wise. I hope you opt for the chemo. Many of us do not achieve a “cure,” but learn to live a new normal while undergoing periodic treatment. It is not what I would have chosen, but I have learned a lot from my illness. Keep going while you regain your footing. A cure might be just around the corner, but regardless you can have good quality of life. Do everything you can to minimize side effects (ice, ice, ice with cotton gloves) and hopefully you will be good to go!

Jump to this post

@juliea55 I also had a bucket of ice I kept my feet in while getting the infusion and I never got neuropathy. And also iced my hands same thing.

REPLY
Profile picture for juliea55 @juliea55

I am not a pharmacist, but I am virtually positive that is not the case. The active drug (and presumably amount) in each infusion is the same. The Abraxane takes less time because it does not elicit the same allergic response.

Jump to this post

@juliea55
I will have post first cycle lab work today and meet with the NP and ask her about abraxane.
Spoke with the nurse yesterday and she said although the allergic reaction scared me, it really wasn't a "bad" reaction which kindly put it in perspective, relative to other people who end up in ER.

REPLY
Profile picture for bocabird @bocabird

@mtstack The oncologist should be able to tell you relevant to your type of cancer

Jump to this post

@bocabird
I will clarify today. I read the range was 0-30 but thought she said 0-38 when I spoke with her.

REPLY
Profile picture for bocabird @bocabird

@juliea55 I also had a bucket of ice I kept my feet in while getting the infusion and I never got neuropathy. And also iced my hands same thing.

Jump to this post

@bocabird
So icing "during" transfusion is a way to treat/forestall neuropathy? I didn't feel it during transfusion. My fingertips started getting sensitive a few days later but it's manageable.
My feet on the other hand have been more troublesome as the aches/pain hinders my walking and standing ability.
I can barely walk one mile when I'd been regularly walking 4-6 mi.
I have not been icing my feet but massaging them and keeping them warm, hoping after the first week, the pain will lessen?

REPLY
Please sign in or register to post a reply.