New antidepressant: Has anyone tried Auvelity?

Posted by csmiller @csmiller, Oct 26, 2022

Anyone know the name of new antidepressant, approved by FDA, that's supposed to be available at end of this year?

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Profile picture for audame @audame

Just started auevelity after trying many other antidepressants. I am running out of hope. I have been on it almost Two weeks and read that it could kick in in a week. Maybe I just got my hopes up. Does anyone know when the sleepiness side effects go away. I have many of the other side effects but it’s too early to give up
How long did it take to kick in for you??

Jump to this post

I have been on Auvelity for just over four months. I did not experience drowsiness in the beginning. I got an immediate bump of motivation to do things. About six weeks in, it really started to improve my mood and motivation to do things. I didn't want to stay in bed and if I wasn't doing something I got fidgety. That was awesome for me!

REPLY
Profile picture for audame @audame

Just started auevelity after trying many other antidepressants. I am running out of hope. I have been on it almost Two weeks and read that it could kick in in a week. Maybe I just got my hopes up. Does anyone know when the sleepiness side effects go away. I have many of the other side effects but it’s too early to give up
How long did it take to kick in for you??

Jump to this post

I appreciate your post. I've been dealing with depression for years.
I've was taking Auvelity for more than 2 weeks (maybe 16 to 18 days) and I could tell no difference in the depression. NONE.
However, the side effects for me was sleeplessness. It disrupted my sleep. It was so unpleasant that I had to stop taking it.

REPLY
Profile picture for ellemccope @ellemccope

Has anyone had success using Auvelity to treat anxiety? I have MDD, GAD, and I suffer from panic attacks. I was on Zoloft for 25 years, but it stopped working around the time of the pandemic. Since then, I’ve tried nearly every antidepressant and anti-psychotic available, but I’m treatment resistant — mostly because I can’t tolerate the side effects or the meds simply don’t work for me. The only thing that has helped somewhat is Mirtazapine (Remeron), but it only helps somewhat with the depression and doesn’t help with anxiety at all. My psychiatrist has suggested Auvelity; so, I just want to know if it has helped anyone with their anxiety.
Thanks so much!

Jump to this post

I am also drug resistant.
I am going to be trying TMS.
Read about it online, very interesting procedure.

REPLY
Profile picture for netter9064 @netter9064

Typically if you are on Medicare, those savings cards aren't eligible. I've tried it for many drugs that are expensive, like Trintelix.

Jump to this post

Trintelix is good with other medicines.
20 mg makes my emotion numb, i could not cry when I needed to and i hat. The doctor reduced it to 10 mg and now 2 days 20mg and 1 day 15 weekly?
I

REPLY

My friend's doctor recommended Auvelity instead of a combination of Buspar, wellbutrin and Trintelix?
Should she give it a try?

REPLY
Profile picture for eliza56 @eliza56

My friend's doctor recommended Auvelity instead of a combination of Buspar, wellbutrin and Trintelix?
Should she give it a try?

Jump to this post

I have never heard of Auvelity or Trintelix. I would love to know about them.
I welcome anyone with information to post it.

REPLY
Profile picture for divinewisdom28 @divinewisdom28

Auvelity. It's a combination of Wellbutrin and dextromorphin. I'm trying to get it prescribed.

Jump to this post

Wouldn't it be a lot cheaper to just take generic Wellbutrin and buy DXM over-the-counter in a cough medicine?

REPLY
Profile picture for daveshaw @daveshaw

I have never heard of Auvelity or Trintelix. I would love to know about them.
I welcome anyone with information to post it.

Jump to this post

My friend swear by Trintelix, She had been on it for a decade and different dosages. Started by itself 5 mg then 10 mg. Then her doctor increased it to 20 mg and her doctor added welbutrin 150 mg. The combination worked very well for almost 1 year.
Tapering off of it and takes only 150 wellbutrin for 2 months.
She started getting worse and the doctor put her on 300 mg for another 4 months without any antipderesent.
All the problems started especially her ringing of the ear. 2 ear specialist prescribed some xnaax and felt much better but stopped 6 weeks.
She got worse,
She started feeling better with taking Trintelix 20 mg, buspar15 mg and wellbutrin 300 for a while.
She felt better for six weeks, but had to reduce Trintelix to 10 mg bc it makes her not be able to cry when she needs to!

REPLY
Profile picture for eliza56 @eliza56

My friend swear by Trintelix, She had been on it for a decade and different dosages. Started by itself 5 mg then 10 mg. Then her doctor increased it to 20 mg and her doctor added welbutrin 150 mg. The combination worked very well for almost 1 year.
Tapering off of it and takes only 150 wellbutrin for 2 months.
She started getting worse and the doctor put her on 300 mg for another 4 months without any antipderesent.
All the problems started especially her ringing of the ear. 2 ear specialist prescribed some xnaax and felt much better but stopped 6 weeks.
She got worse,
She started feeling better with taking Trintelix 20 mg, buspar15 mg and wellbutrin 300 for a while.
She felt better for six weeks, but had to reduce Trintelix to 10 mg bc it makes her not be able to cry when she needs to!

Jump to this post

Now the question is should she switch from the combination to Auvelity????

REPLY
Profile picture for eliza56 @eliza56

My friend swear by Trintelix, She had been on it for a decade and different dosages. Started by itself 5 mg then 10 mg. Then her doctor increased it to 20 mg and her doctor added welbutrin 150 mg. The combination worked very well for almost 1 year.
Tapering off of it and takes only 150 wellbutrin for 2 months.
She started getting worse and the doctor put her on 300 mg for another 4 months without any antipderesent.
All the problems started especially her ringing of the ear. 2 ear specialist prescribed some xnaax and felt much better but stopped 6 weeks.
She got worse,
She started feeling better with taking Trintelix 20 mg, buspar15 mg and wellbutrin 300 for a while.
She felt better for six weeks, but had to reduce Trintelix to 10 mg bc it makes her not be able to cry when she needs to!

Jump to this post

Thanks for the answer.
Why doesn’t she try Zoloft or another SSRI along with Wellbutrin. They work very well in combination and at one point they had a nickname “welloft”. Buspar could also give her more relief and clonazepam could help with anxiety.
I know there are “haters” out there regarding any benzodiazepines and yes I know they are addictive. That being said if you never increase your dosage and use them responsibly they can have a positive effect especially for those suffering from acute anxiety.
Many claim withdrawal is very difficult and it is but so is withdrawal from things such as alcohol, nicotine and sugar among other things. Some say withdrawal from nicotine is worth that withdrawal from heroin.
I recently talked to a nurse who gave up smoking and started vaping. She said because of the amount of nicotine that is in vaping it has been harder to quit vaping than it was to quit smoking.
If you have severe anxiety don’t rule out responsible use of a benzo. Unlike opioids I have never heard of someone dying from taking a benzo. Just be responsible and don't increase your dosage.
Good luck to you.

REPLY
Please sign in or register to post a reply.