Getting off of Seroquel

Posted by anniegk @anniegk, Jun 8, 2018

I have been on 300 mgs. Seroquel ER for over a year for augmenting my antidepressant which is 45 mgs. Of Mirtazapine. I decided to try and get off of the Seroquel. I was on 300mgs ER (extended release). I titrated down to 250 mg ER for 2 months without too many problems.than i titrated down to 200mgs ER just 5 days ago. My plan is to try to titrate off using ER tablets. My thinking is that perhaps the drug will remove its self from my system more gradually. I have had some nausea and a couple of episodes of diarrhea. I also have a very irregular heart beat and was started on 60 mgs of Propranolol ER (extended release) 4 weeks ago. It seems to be helping my heartbeat. I have wondered if the nausea and light headness is from the Propranolol, a Beta Blocker, or the dose reduction of the Seroquel. I also wonder if the way iam titrating the Seroquel is safe. My doctor says it will only take a couple of weeks...I think that is too fast of a taper after being on a drug for over a year. What do you think?

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Profile picture for ginak523 @ginak523

I just stopped it cold turkey and feel much better ! Thank you for responding .

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Did you have bad side effects?

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comment on side effects

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Profile picture for radams3928 @radams3928

My son was recently in a psychiatric facility for severe depression and anxiety. While in the facility they started him on Lexapro 10 mg and Seroquel 100 mg. They were giving my son 200-300 mg of Seroquel per day. When they discharged him they only gave him a script for the Lexapro and when my son asked about the Seroquel they said they wouldn’t give him a script for that due to it being habit forming. On the 2 1/2 hr drive home I could tell he had some anxiety. He said he did not take the Seroquel that morning at the facility since he was being discharged. So that same night my son takes his Lexapro about 8 pm and literally hour later a full on panic attack. He has never had panic attacks just anxiety. He was freaking out , hyperventilating, sweating profusely, his legs went numb, his hands and finger tips were tingling , his chest got tight , his blood pressure shot up. He was crying. It was absolutely awful. He has had the shakes and I could literally see his legs trembling as he went down the stairs of the house. I’m so worried that this could be a withdrawal from the Seroquel. He was taking 200-300 mg a day for about 5 days. Is it possible that he is having withdrawals only after being on it for 5 days ?

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. Hi there I have suffered with my mental health very badly the last couple of years . Somehow after a stay in hospital I ended up on seroquel . I do not have psychosis or bipolar and my diagnosis they think is BPD and maybe possibly adhd/autism. I’ve realised that it never took away my severe and dissociation. And I got better myself each time I have these episodes of being unwell. I am on 250xr and I have been for about 3 years. Taking 25mg throughout the day as needed but can stop them no problem And have done so . I take sertaline 25mg also not sure it does much either . Anyway with weight gain having really upset my self esteem as a side effect and the benefits not outweighing the negatives I want to get off it . I know my doctor will help me however I’m so so so sensetive to any change in anything and a drop of anything can send me sideways if my body is used to it. I’m just so sensetive to chemicals so I actually think I need to maybe be just on the least amount of medication possible . My question is what is the slowest and or best way to do this to minimise it kicking me into severe anxiety. 50mg jumps are fast however I know you can’t cut the xr in half . But do adding in the instant release suffice to cushion the blow of the drops. Like going to 225 meaning 200xr and one 25mg instant . Any help would be appreciated!

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Profile picture for katiejok @katiejok

. Hi there I have suffered with my mental health very badly the last couple of years . Somehow after a stay in hospital I ended up on seroquel . I do not have psychosis or bipolar and my diagnosis they think is BPD and maybe possibly adhd/autism. I’ve realised that it never took away my severe and dissociation. And I got better myself each time I have these episodes of being unwell. I am on 250xr and I have been for about 3 years. Taking 25mg throughout the day as needed but can stop them no problem And have done so . I take sertaline 25mg also not sure it does much either . Anyway with weight gain having really upset my self esteem as a side effect and the benefits not outweighing the negatives I want to get off it . I know my doctor will help me however I’m so so so sensetive to any change in anything and a drop of anything can send me sideways if my body is used to it. I’m just so sensetive to chemicals so I actually think I need to maybe be just on the least amount of medication possible . My question is what is the slowest and or best way to do this to minimise it kicking me into severe anxiety. 50mg jumps are fast however I know you can’t cut the xr in half . But do adding in the instant release suffice to cushion the blow of the drops. Like going to 225 meaning 200xr and one 25mg instant . Any help would be appreciated!

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Severe anxiety and dissociation *

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Profile picture for katiejok @katiejok

. Hi there I have suffered with my mental health very badly the last couple of years . Somehow after a stay in hospital I ended up on seroquel . I do not have psychosis or bipolar and my diagnosis they think is BPD and maybe possibly adhd/autism. I’ve realised that it never took away my severe and dissociation. And I got better myself each time I have these episodes of being unwell. I am on 250xr and I have been for about 3 years. Taking 25mg throughout the day as needed but can stop them no problem And have done so . I take sertaline 25mg also not sure it does much either . Anyway with weight gain having really upset my self esteem as a side effect and the benefits not outweighing the negatives I want to get off it . I know my doctor will help me however I’m so so so sensetive to any change in anything and a drop of anything can send me sideways if my body is used to it. I’m just so sensetive to chemicals so I actually think I need to maybe be just on the least amount of medication possible . My question is what is the slowest and or best way to do this to minimise it kicking me into severe anxiety. 50mg jumps are fast however I know you can’t cut the xr in half . But do adding in the instant release suffice to cushion the blow of the drops. Like going to 225 meaning 200xr and one 25mg instant . Any help would be appreciated!

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It's true that the extended-release tablets can't be cut, which makes those smaller drops tricky. A lot of people in similar situations have talked about how they use the immediate-release tablets to help with tapering. For example, if you wanted to drop from 250mg to 225mg, you could take a 200mg XR tablet and then add in a 25mg immediate-release tablet. This way, you can make smaller adjustments than 50mg jumps.
The key thing that I've seen others mention is to go slowly as you feel is necessary. Some people even take months or longer for a taper, especially after being on it for a long time. It gives your body and brain a chance to adjust.
Your doctor will certainly take care of the situation, and you should follow his instructions, but on top of that, you can try to focus on other things to help with the anxiety. Things like having a consistent sleep schedule, getting some light exercise, and using some relaxation techniques that are comfortable and effective in your case.
Just take one step at a time, and listen to what your body is telling you. Good luck!

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Profile picture for katiejok @katiejok

. Hi there I have suffered with my mental health very badly the last couple of years . Somehow after a stay in hospital I ended up on seroquel . I do not have psychosis or bipolar and my diagnosis they think is BPD and maybe possibly adhd/autism. I’ve realised that it never took away my severe and dissociation. And I got better myself each time I have these episodes of being unwell. I am on 250xr and I have been for about 3 years. Taking 25mg throughout the day as needed but can stop them no problem And have done so . I take sertaline 25mg also not sure it does much either . Anyway with weight gain having really upset my self esteem as a side effect and the benefits not outweighing the negatives I want to get off it . I know my doctor will help me however I’m so so so sensetive to any change in anything and a drop of anything can send me sideways if my body is used to it. I’m just so sensetive to chemicals so I actually think I need to maybe be just on the least amount of medication possible . My question is what is the slowest and or best way to do this to minimise it kicking me into severe anxiety. 50mg jumps are fast however I know you can’t cut the xr in half . But do adding in the instant release suffice to cushion the blow of the drops. Like going to 225 meaning 200xr and one 25mg instant . Any help would be appreciated!

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Ye I’ve never managed to get my anxiety to go away completely I get unwell like every year for a few months no medication helps actually being assessed to see if I’m neurodivergent cause my nervous system is so dysregulated. That’s why coming off gently is really important for me I react Terrible to any chemical changes . Thanks for the advice. I wil do it that way

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Profile picture for highserotonin30 @highserotonin30

Thanks for the help. I want to stop taking it because I've gained almost 90 lbs since I've started my treatment. It seems to me that at this point, the negative health consequences far outweigh any antidepressive qualities the Seroquel has had on me. I'm still depressed and very anxious. The only exception is that now I also have about 80 extra pounds to show for it. I'll make sure to check out those other discussions.

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