High Coronary Calcium Score: How do others feel emotionally?

2mg/d of pitavastatin (Livalo). I'd do an angio in a 'heartbeat' but I have a very bad reaction to contrast (delayed systemic hypersensitivity reaction - like systemic poison oak - lobster red skin and unmitigated itching for a month - totally disabling and unresponsive to everything). I must work and cannot be disabled or it'll be economically disastrous. Plus, as chief of my hospitalist service, I have to do all that this entails. Obviously, should I have a coronary event, I'll have to have an angio, and I'll pre-treat with high dose steroids, having to accept the risks inherent with that. Story of my life - lots of rocks and hard places....

Also, I had a high CAC score before I started statins. I know about the statin - calcification effect. So it goes.

Thanks for posting your results. I'm sorry that the chelation treatments didn't lower your CAC score. All the best to you in managing the risk factors that are in your control.

Yikes! That's a nasty reaction. The advantage of Livalo is that compared to Atorvastatin it doesn't change blood sugar levels. My Cardiologist wants me om 80mg of Atorvastatin, but I'm reluctant to take that high of a dose.

My liver and muscle enzymes went up on 40 of lipitor. They're fine on pitavastatin. fwiw.....

Bluesdoc, I am sorry that your CAC score did not go down. I wish you all the best and, if you come up with a way out of the mess that we all wade in, please let us know.

I just did a bit of research on Minocycline and found a current paper by Muller et al. (June 11, 2019, Cell Reports 27, 3124-3138). It can be found at https://doi.org/10.1016/j.celrep.2019.05.038. It is very technical and long, but seems pertinent to our discussion. The authors conclude that "Inhibiting PARP enzyme activity blocks calcification in vitro and in vivo. They write that Minocycline is the best PARP inhibitor. It would be great if Bluesdoc, or anyone else with an appropriate background could take a look at this major, current study and comment. Looks to me that Minocycline may be helpful in halting the progress or even reversing atherosclerosis.

Came across this article that may be of interest too.
https://www.sciencedaily.com/releases/2018/04/180419141523.htm

I have to be skeptical of any study with only 20 subjects that is funded by the company making the supplement!

I believe the study was funded by NIH. (The study was funded by the National Institutes of Health. MitoQ Limited provided supplements and some financial support.) It was very small, you are correct. If dramatic results were achieved, maybe a larger, expanded study will follow?

"I'm otherwise going to do my best to not dwell on things I can't do anything about. None of us are gettin' out of here alive, so, carpe diem."
This has been my constant call to my wife who, as a result of chemo from CLL, now has MDS. It was all very easy to sit back and play cheerleader until I passed out at a sub shop which led to a series of cardio tests and discovered my CAC at 662. Then i was the one freaking out! The stress test looked ok when under stress but, afterward, something looked odd so did a heart cath on Tues. My world changed again when that came back with 25% blockage except for a small spot on LAD with 40%. I was and still am elated!

I'm 65, have eaten pretty well and exercised religiously for at least 20 years but, just like my wife, somethings you can't control. Mine is most likely genetics but I never knew my father and maternal grandfather died at 66 from a heart attack. The MD who did the procedure said simply "keep doing what you're doing" meaning he thought I looked pretty good. So now my focus is to further improve on my diet and exercise. Admittedly, after I retired a year ago, I'd been slacking off somewhat but now I need to get back on track for the long haul.