Why don’t anxiety meds work for me?

Posted by dorothy1914 @dorothy1914, Feb 13 5:13pm

In Sept. 2024 out of nowhere I developed extreme anxiety. Went to primary care doctor and was prescribed Effexor (which I had successfully taken previously). This time it didn’t provide any help. Dr. then prescribed Lexapro (which didn’t help) and then Celexa (which didn’t help). By this time, I lost 45 pounds by not being able to eat and constant diarrhea. Dr. then told me to find another practitioner as there was nothing more she could do for me. Since then I have seen 4 PNP and none of their prescribed meds have helped. What do I do?

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@jschwing

Yes. I am taking Trazadone in the evenings to assist with sleep. I went off of it for about a month, but was struggling so recently resumed. The issue is that I just am not sure that I am metabolizing properly and the results of the medications are very mitigated. Accept lots of side effects from most on the prescribed medications that have been tried.

Not sure if you have ever heard of KPU? But my last testing was over 80 with a 20 being the high end of the range. The high KPU affects the high level of secretion of very important nutrients ; example B6 and Zinc that impact mental issues due to the metabolism limitations

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@jschwing
I just made an appointment to have my labs done on Friday. To be quite honest with you, I don’t know how I am going to make it there as I feel worse every day. My husband will drive me there as he’s had to do since Sept. when my symptoms returned one thousand fold. Today was horrible. Last night my heart palpitations were crazy and as usual, I was up all night. Ear buzzing is so loud I bet my next door neighbors can hear it. I talked with my sister tonight. At first I thought I would just tell her I am in no condition to talk but then I changed my mind. I don’t know, though, if talking to her made me feel worse but how can I feel any worse than I already do. I am so discouraged.

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@dorothy1914

@jschwing
I just made an appointment to have my labs done on Friday. To be quite honest with you, I don’t know how I am going to make it there as I feel worse every day. My husband will drive me there as he’s had to do since Sept. when my symptoms returned one thousand fold. Today was horrible. Last night my heart palpitations were crazy and as usual, I was up all night. Ear buzzing is so loud I bet my next door neighbors can hear it. I talked with my sister tonight. At first I thought I would just tell her I am in no condition to talk but then I changed my mind. I don’t know, though, if talking to her made me feel worse but how can I feel any worse than I already do. I am so discouraged.

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Claudia:

Sorry to hear that. Are you dealing with depression as well along with the anxiety?

You may want to inquire about KPU . This is a measure of components that inhibit the ability to detox and to properly metabolize certain elements like B6 and Zinc. This is challenging because it inpacts your ability to properly metabolize medications which causes side effects without results intended.

Mine is four times higher than high range. You may want to look into this. Standard labs likely would not be knowledgeable and you may need to look for a more naturopathic psychiatrist to explore this. Then, treatment is generally supplements and certain foods.

I know this is a lot, but I wanted to at least let you know about this due to the fact that both of us are resistant to the medications.

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I am suffering from protracted withdrawal. It is terrible. I don’t know where to get help. I’ve been watching videos on Utube from Dr. Josef.

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@dorothy1914

@jschwing
I just made an appointment to have my labs done on Friday. To be quite honest with you, I don’t know how I am going to make it there as I feel worse every day. My husband will drive me there as he’s had to do since Sept. when my symptoms returned one thousand fold. Today was horrible. Last night my heart palpitations were crazy and as usual, I was up all night. Ear buzzing is so loud I bet my next door neighbors can hear it. I talked with my sister tonight. At first I thought I would just tell her I am in no condition to talk but then I changed my mind. I don’t know, though, if talking to her made me feel worse but how can I feel any worse than I already do. I am so discouraged.

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Claudia:
I am suffering from severe depression along with the anxiety. I can physically feel my eyes weak and burning and sensations in my front of the head ; the frontal cortex. I too have lost a lot of weight; too much. And when I do eat larger meals it almost seems that my gut is not processing the food properly in order for weight gain. My Doctor wanted me to try Tritelix, but I am not sure I will try another psych med at this time. Stuck right now because even though I tell myself I am healing, the depression seems to be constant. Have to force myself to do anything with what feels like brain malfunction and lack of executive function.

So I do know the level of suffering with no clear medication path to assist.

Have tried all the mindfulness routes and brain rewire programs, neuro feedback, acupuncture, cold therapies, and now detox and supplements to try to mitigate effects of elevated KPU.

This has been going on since early June 2024 and now beginning to have a lot of physical muscle pain within the body.

I hope you have a better day today and tomorrow. We need to focus and celebrate the wins daily even though we physically feel really lousy at the time. Today I did yard work out front and it was very difficult and hard to find the energy. I am celebrating that I did it anyway and thankful I can still walk. Pain is there, but I am still walking and mobile; I sure will never take that for granted. Things can change so quickly. So my prayer is that positive change to the condition occurs even if it is just small gains over a long period. Just transitioning off the meds that did not work correctly seemed to set me back every time. I am still taking Trazadone at night in an attempt to get some sleep. My other prayer is that the sleep gets deeper and longer cycles.

The ringing in the ears is likely a result of Benzodiazepines. Are you still taking these from time to time?

Hope you are doing just a little bit better Claudia.

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@jschwing

Claudia:
I am suffering from severe depression along with the anxiety. I can physically feel my eyes weak and burning and sensations in my front of the head ; the frontal cortex. I too have lost a lot of weight; too much. And when I do eat larger meals it almost seems that my gut is not processing the food properly in order for weight gain. My Doctor wanted me to try Tritelix, but I am not sure I will try another psych med at this time. Stuck right now because even though I tell myself I am healing, the depression seems to be constant. Have to force myself to do anything with what feels like brain malfunction and lack of executive function.

So I do know the level of suffering with no clear medication path to assist.

Have tried all the mindfulness routes and brain rewire programs, neuro feedback, acupuncture, cold therapies, and now detox and supplements to try to mitigate effects of elevated KPU.

This has been going on since early June 2024 and now beginning to have a lot of physical muscle pain within the body.

I hope you have a better day today and tomorrow. We need to focus and celebrate the wins daily even though we physically feel really lousy at the time. Today I did yard work out front and it was very difficult and hard to find the energy. I am celebrating that I did it anyway and thankful I can still walk. Pain is there, but I am still walking and mobile; I sure will never take that for granted. Things can change so quickly. So my prayer is that positive change to the condition occurs even if it is just small gains over a long period. Just transitioning off the meds that did not work correctly seemed to set me back every time. I am still taking Trazadone at night in an attempt to get some sleep. My other prayer is that the sleep gets deeper and longer cycles.

The ringing in the ears is likely a result of Benzodiazepines. Are you still taking these from time to time?

Hope you are doing just a little bit better Claudia.

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@jschwing
Just heard back from a mental health provider I was hoping to see to get more info on protracted withdrawal. He said I should seek help elsewhere with an addiction specialist. I am not addicted to anything as I don’t take anything. Where do I go from here?

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@dorothy1914

@jschwing
Just heard back from a mental health provider I was hoping to see to get more info on protracted withdrawal. He said I should seek help elsewhere with an addiction specialist. I am not addicted to anything as I don’t take anything. Where do I go from here?

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The standard MD Community does not recognize and understand the term protracted withdrawal. In their opinion, when a drug is tapered off of it is out of the body and there should be no additional effects on the body. But, we know that this is certainly not true. It is a real thing and how to avoid it is sometimes impossible due to genetics, the ability to effectively remove toxins, metabolism etc. Also , MD doctors do not like a patient to discuss anything other than symptoms so that they can make a diagnosis and prescribe medications. They do not have the ability to spend the time to look for root cause etc. Finally, they do not know how to treat protracted withdrawal; not sure anyone really does have any consistent answers. These withdrawals can occur with SSRI drugs and certainly benzodiazepines. I believe you will have to seek out a naturopathic psychiatrist to get any answers or a plan forward.

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@jschwing

The standard MD Community does not recognize and understand the term protracted withdrawal. In their opinion, when a drug is tapered off of it is out of the body and there should be no additional effects on the body. But, we know that this is certainly not true. It is a real thing and how to avoid it is sometimes impossible due to genetics, the ability to effectively remove toxins, metabolism etc. Also , MD doctors do not like a patient to discuss anything other than symptoms so that they can make a diagnosis and prescribe medications. They do not have the ability to spend the time to look for root cause etc. Finally, they do not know how to treat protracted withdrawal; not sure anyone really does have any consistent answers. These withdrawals can occur with SSRI drugs and certainly benzodiazepines. I believe you will have to seek out a naturopathic psychiatrist to get any answers or a plan forward.

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@jschwing
I don’t know what a naturopathic psychiatrist is really or where to find one but thank you for your response. I am just sitting in the living room shaking and filled with fear.

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