Why don’t anxiety meds work for me?

Posted by dorothy1914 @dorothy1914, Feb 13 5:13pm

In Sept. 2024 out of nowhere I developed extreme anxiety. Went to primary care doctor and was prescribed Effexor (which I had successfully taken previously). This time it didn’t provide any help. Dr. then prescribed Lexapro (which didn’t help) and then Celexa (which didn’t help). By this time, I lost 45 pounds by not being able to eat and constant diarrhea. Dr. then told me to find another practitioner as there was nothing more she could do for me. Since then I have seen 4 PNP and none of their prescribed meds have helped. What do I do?

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Profile picture for 1gratefuldawg @1gratefuldawg

Have you heard of Audio-visual entrainment, a subset of brainwave entrainment, uses flashes of lights and pulses of tones to guide the brain into various states of brainwave activity. AVE devices are often termed light and sound machines or mind machines. Altering brainwave activity is believed to aid in the treatment of psychological and physiological disorders. I bought a Kasina Mind Media system. It helps me go to sleep, there are preprogrammed relaxation, meditation, sleep, learn sessions and you have the ability to write your own. Might be worth looking into. For reference purposes I’m 70. I also live in Arizona.

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@gratefuldawg
Thank you for your suggestion. I think something like that might make my frazzled nerves worse. Every little sound startles me and I am sensitive to light. Going through protracted withdrawal from Effexor has been a nightmare as you never know what bizarre symptom might pop up next.

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My old psychiatrist had a DNA test on me to see which meds work for me and which don't. You might want to ask about that.
They were doing optional for all their patients, and the nurse did inform me if my insurance wouldn't cover it, because of our financial situation they would wave the bill. And we never did see a bill.
And have you tried Clonazepam?

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Profile picture for alana68 @alana68

My old psychiatrist had a DNA test on me to see which meds work for me and which don't. You might want to ask about that.
They were doing optional for all their patients, and the nurse did inform me if my insurance wouldn't cover it, because of our financial situation they would wave the bill. And we never did see a bill.
And have you tried Clonazepam?

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@alana68 have not tried clonazepam. Dr. suggested it but I had read a lot of horror stories about it. Have not had DNA testing either. Going through protracted withdrawal now and it is beyond any kind of description. Can’t leave the house. Have no medication of any kind.

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Profile picture for dorothy1914 @dorothy1914

@gratefuldawg
Thank you for your suggestion. I think something like that might make my frazzled nerves worse. Every little sound startles me and I am sensitive to light. Going through protracted withdrawal from Effexor has been a nightmare as you never know what bizarre symptom might pop up next.

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You have full control of sound volume and light intensity .

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Profile picture for ddscal1958 @ddscal1958

You should have the Genomind test for find out if you have the MTHFR gene mutation, this may be causing your meds not to work. I would definitely check it out. Best of luck

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Also, Genomind will work with you on cost. After the test. Just tell them you cannot afford the full amount.
I only had to pay $300. Good luck
God bless

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Profile picture for clazzygalxo @clazzygalxo

I can’t know for sure why they don’t help you but I’m a person they don’t help either.

A few reasons in my case.

1) I’m highly treatment resistant when it comes to drugs overall. Especially SSRIs and A/Ds overall. I get very sick with side effects and eventually have no choice but to quit taking them.

2) Most important thing to ensure is that you’ve been properly diagnosed. For over a decade, I tried anything and everything and NOTHING worked. Just recently I finally learned why and it’s because I was never properly diagnosed and that in of itself was a huge part of the problem.

With my condition, I should NEVER be taking A/Ds.

This may not be the case for you at all but if you’re unsure, it might be something for you to consider.

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What were you diagnosed with? I’m struggling to get on antidepressants and nothing is working.

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Profile picture for mlpbob @mlpbob

What were you diagnosed with? I’m struggling to get on antidepressants and nothing is working.

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@mlpbob
I have anxiety and depression and the Effexor worked for 30 years and then I stupidly went off of it without a proper taper. All my fault.

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Profile picture for dorothy1914 @dorothy1914

@mlpbob
I have anxiety and depression and the Effexor worked for 30 years and then I stupidly went off of it without a proper taper. All my fault.

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Anxiety and depression. I was doing fine on Paxil and new primary care told me everyone should try once to go off their medication. Big mistake. Can’t get back on anything

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Profile picture for mlpbob @mlpbob

Anxiety and depression. I was doing fine on Paxil and new primary care told me everyone should try once to go off their medication. Big mistake. Can’t get back on anything

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@mlpbob
I don’t know what to say. I thought I was the only one suffering like this but in my case it was my poor decision that ruined my life.

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Profile picture for dorothy1914 @dorothy1914

Thank you so much for your response. I currently am not on any medication. My last provider said she would no longer treat me if what she prescribed (Zoloft and Gabapentin) did not work for me. Well, they didn’t. I had weird brain/head sensations from one of them. I was also prescribed Buspar from another provider but I was allergic to it. I just retried Effexor 37.5 xr, but it just increased my anxiety. It has been a repeat cycle of going on a drug and a few days later, coming off of it due to intolerable side effects. I feel pretty hopeless. I have been reluctant to take Ativan which has been prescribed by my PCP for my anxiety as I know I will wind up taking too many, so I am suffering with no relief in sight. I have a very stressful situation at home as my husband has Parkinson’s Disease and instead of me taking care of him, he has to take care of me.

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I am in the exact same boat as you are as nothing works for me. Ativan a.k.a. lorazepam does work for me, but we’re a normal human has to take one and they sleep for two days. I need Three to just calm down enough to where I don’t look like a manic all the time. And when it comes to sleep and I can’t sleep due to insomnia, they won’t give me Ambien or a Xanax so they give me like 12 different meds that they act like are wonderful and work for everyone and when it doesn’t work for me, they look at me and basically accuse me of lying. So then the bottom line comes to the only way you can get relief is to buy what you need on the street. I have literally taken 150 mg of trazodone along with 150 mg of diphenhydramine, which is in sleep medication along with my regular meds and still been up for well over 30 hours and ready to paint the house. And when I am honest with my doctors, which is all the time they just get mad and like you said with you, they canceled me. I asked one of my psychiatrist a few years ago why she wouldn’t allow me to at least try these other meds to rule them out or what not and she couldn’t give me a reason so then I asked her if she was getting kickbacks and three days later, I got a letter in the mail saying that I was canceled. Oh and I did get the genetic marking test done and it’s a company called Gen0mind. That when I had it done, it was upwards of $5000. Hopefully if you get it done it’ll be covered by insurance. Insurance usually sees it as something that is not dire so they don’t pay for it. But on a good note when I got my testing back, it did make me feel a lot better because the doctors on the phone told my doctor that like 90% of the world that gets the testing done has normal results easy to read you need more of this medication you need less of this medication yada yada yada But with me and almost every single medication on there from Tylenol to benzos to pain meds one medication I would need more of half of that medication unless of the other half of that medication!! Crazy right?!? Because you can’t take something like well. I can’t think of an example but you can’t take one medication that’s in one pill form or capsule and somehow be able to split up the ingredients so that I can take more of part of it and less of the other part. That test actually helped me a lot because when I found my newest psychiatrist one of the first things I did was send her a copy of that and also since I’m a redhead, I keep the little card that they gave me in my wallet in case I have an accident because under anesthesia, any anesthesiologist worth their salts, know that any redhead is going to need way more anesthesia than a normal person. Anyway, I hope you get the testing done and I hope you find something that works. Oh and I don’t know if this is part of your problem, but I have ADHD and OCD and because of those diagnoses things affect me back backwards. GOOD LUCK AND GOD SPEED!!

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