Eliquis side effects

I take so many meds a day anymore hard to know what affects what .... been on Eliquis since 8-2022 after a stroke I was on Plavix for years then the Dr. never noticed that it had stopped working and caused me to have a stroke.

I also had a stroke but only took Eliquis after that as I suffered post surgical blood clots prior to the stroke. Plavix was only given to me for a month post strike as the surgeon had inserted a stent into my R carotid artery during the clot retrieval from my brain. I too take so many pills mainly for blood pressure control. Eliquis is a life saving drug but as all drugs side effects happen. My main complaint is a bowel issue but I don’t know if the problem is caused by that drug or one of the 9 others!!

I should probably start out by saying I'm in medicine and also married to a Dr, so I do have a good awareness of what is normal and not normal. I had an episode of Atrial Fib (resolved completely for 3.5 months) and was placed on Eliquis 5 mg, twice a day. Within 2 weeks I had a bizarre onset of severe numbness in my toes. A week later I started having muscle spasms all over my body and some weakness too. These spasms are not like the ones you get when you've worked out. They might be in the compartment of my thumb, then my whole hamstring muscle, then in muscles between my ribs, all in the same hour! I was a very healthy and very active person used to exercising daily, so these changes have REALLY been unusual! Another thing I've noticed is that about 2-3 hours after I take the Eliquis, I'm so tired I want to lay down and sleep. Now, I'm a high energy person who NEVER goes to sleep before midnight (and NEVER takes naps!), but for 2 months now I've been falling asleep by 9 pm at night! I'm also laying down for a nap around noon. It's VERY bizarre! Maybe I wouldn't complain as much if it was good sleep at night but I'm jumping up with muscle spasms all night long. They have ruled out other systemic causes of these issues and I finally believe it must be caused by the Eliquis. I don't think this medication is benign as the company is making the Drs believe.

I developed a clot in leg (we think from covid), started eloquis Nov 1 in hospital and within several weeks noticed extreme pain in legs, including knees. I've always been an athlete, rowing, running and now tired, fatigued, and pain is unbearable. Asked Vascular and Hematology Dr.s who say "no cannot be from eloquis".
Why are Dr's so quick to dismiss odd symptoms especially when a patient who's a very active person and cannot even walk. I want to stop taking it since ultrasounds show no clot but they say too soon.
Has anyone noticed leg pain from eloquis?

Welcome @ccorn, I had a blood clot in my right leg followed by a POE in my lungs not quite 2 years ago. I'm still on Eliquis but it's down to 2.5 mg twice daily. I haven't experienced the leg pain you mentioned but I think I might seek a second opinion if my doctor dismissed my concerns. Here's some information I found that may be helpful:

"Can Eliquis make your legs hurt?
Having certain spinal procedures during Eliquis treatment may increase the risk of blood clots in your spine. Symptoms of blood clots in your spine include: numbness or weakness in your legs. tingling."
-- Eliquis Side Effects: What They Are and How to Manage Them:
https://www.healthline.com/health/drugs/eliquis-side-effects
Have you thought about getting a second opinion?

I developed a clot in leg (we think from covid), started eloquis Nov 1 in hospital and within several weeks noticed extreme pain in legs, including knees. I've always been an athlete, rowing, running and now tired, fatigued, and pain is unbearable. Asked Vascular and Hematology Dr.s who say "no cannot be from eloquis".
Why are Dr's so quick to dismiss odd symptoms especially when a patient who's a very active person and cannot even walk. I want to stop taking it since ultrasounds show no clot but they say too soon.
Has anyone noticed leg pain from eloquis?