Effexor Tapering Off and Side Effects

Posted by gaile12 @gaile12, Aug 22, 2022

I am tapering off Effexor after being on it for over a decade. I've noticed my stomach gets queasy & I have digestion issues. Has anybody else had this problem?

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Profile picture for m1rty @m1rty

I've been taking Effexor XR daily for 20 years. My prescription is for three 75mg capsules (225mg total) once a day. I want to get off this medication, so my doctor suggested I try to taper off by only taking two XR capsules instead of the three capsules. I thought this might be too much of a decrease, so she suggested I add a regular 37.5mg Effexor tab to the two XR capsules to make it easier and try that for 2-4 weeks. If no major issues I could then decrease my dosage a little bit more. Does this sound reasonable?

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Thanks! I am grateful for your input. I wonder if taking the 37.5 tablet later in the day is better than taking it in the morning when I take the two ER capsules.

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Profile picture for m1rty @m1rty

I've been taking Effexor XR daily for 20 years. My prescription is for three 75mg capsules (225mg total) once a day. I want to get off this medication, so my doctor suggested I try to taper off by only taking two XR capsules instead of the three capsules. I thought this might be too much of a decrease, so she suggested I add a regular 37.5mg Effexor tab to the two XR capsules to make it easier and try that for 2-4 weeks. If no major issues I could then decrease my dosage a little bit more. Does this sound reasonable?

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Is it ok to go from 37.5 mg Effexor XR to 37.5 mg regular Effexor as a means of tapering ?

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Profile picture for m1rty @m1rty

I've been taking Effexor XR daily for 20 years. My prescription is for three 75mg capsules (225mg total) once a day. I want to get off this medication, so my doctor suggested I try to taper off by only taking two XR capsules instead of the three capsules. I thought this might be too much of a decrease, so she suggested I add a regular 37.5mg Effexor tab to the two XR capsules to make it easier and try that for 2-4 weeks. If no major issues I could then decrease my dosage a little bit more. Does this sound reasonable?

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Is there a slower way of going off Effexor 38.5mg XR to zero? Can it be compounded? . I’ve gotten down to 37.5 mg XR for last 2 weeks. Lots of withdrawal symptoms . Anxious about going down to zero. Any suggestions?

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Profile picture for mialucy123 @mialucy123

Is it ok to go from 37.5 mg Effexor XR to 37.5 mg regular Effexor as a means of tapering ?

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My pharmacist it depends on the individual and you should consult with your doctor.

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Profile picture for m1rty @m1rty

I've been taking Effexor XR daily for 20 years. My prescription is for three 75mg capsules (225mg total) once a day. I want to get off this medication, so my doctor suggested I try to taper off by only taking two XR capsules instead of the three capsules. I thought this might be too much of a decrease, so she suggested I add a regular 37.5mg Effexor tab to the two XR capsules to make it easier and try that for 2-4 weeks. If no major issues I could then decrease my dosage a little bit more. Does this sound reasonable?

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I would suggest you look at other posts on this subject on this site, which are extensive. Sadly, not all doctors know how to assist their patients in tapering off a drug. I am fortunate to have found an independent compounding pharmacist who is willing to help me discontinue the drug according to The Maudsley Deprescribing Guidelines (Mark Horowitz and David Taylor, published this year).

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Profile picture for njoys @njoys

I would suggest you look at other posts on this subject on this site, which are extensive. Sadly, not all doctors know how to assist their patients in tapering off a drug. I am fortunate to have found an independent compounding pharmacist who is willing to help me discontinue the drug according to The Maudsley Deprescribing Guidelines (Mark Horowitz and David Taylor, published this year).

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Thanks for the info. I will check into that.

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Profile picture for keola07 @keola07

Hello everyone, I have been in effexor for fifteen years been on 150 for seven. Finally found out a lot of my issues were do to ADHD so was on the wrong med. Finally think I found a good ADHD medsso been trying to lower my dose of effexor with psychatrist help. I went from 150 to 75. During the first few weeks felt vertigo and Shakey that went away. Then about four weeks into it felt body shocks. Now I feel like itchiness in scalp and tingling and brain zaps. Is this a normal side effects? Also thinking I jumped to big of a dose so thinking about going up 37.5 then taper off again from there. I do have a psych and he recommended that he is fantastic. It's been hard and stressful. But I am getting through it. Thank you for listening. Blessings.

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I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

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Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

Jump to this post

I am in a similar place as you. I tapered from 225 to 75 over 4 weeks. I need to discontinue effexor because it caused my liver enzymes to get extremely high, and the doctor is concerned about my liver.
The first drop from 225 to 150 put me in the ER. Too much! My Dr. knew nothing about possible severe withdrawal symptoms. I sat there for two weeks. I decided the next reduction should be smaller, from 150 to 112.5. This was much better, with a few manageable side effects. That was one week. This week, I reduced from 112.5 to 75, and the anxiety has been awful. I'm exhausted, but can't sleep because my body and mind won't settle. I have burning nerve pain, tremors, and some nausea. Like you, my emotions are dysregulated, especially in the late afternoon.
I'm hoping my latest blood test shows some improvement in my liver enzymes, so I can at least feel like all the suffering has been for something.
I, too, would like to hear some success stories. I have a great support system, and talk to a therapist once a week. I'm lucky that I'm newly retired, so I can stay home to deal with this.
I hope things improve for all of us soon. It's all very scary because of all the unknowns.

REPLY
Profile picture for mmsm @mmsm

I am in a similar place as you. I tapered from 225 to 75 over 4 weeks. I need to discontinue effexor because it caused my liver enzymes to get extremely high, and the doctor is concerned about my liver.
The first drop from 225 to 150 put me in the ER. Too much! My Dr. knew nothing about possible severe withdrawal symptoms. I sat there for two weeks. I decided the next reduction should be smaller, from 150 to 112.5. This was much better, with a few manageable side effects. That was one week. This week, I reduced from 112.5 to 75, and the anxiety has been awful. I'm exhausted, but can't sleep because my body and mind won't settle. I have burning nerve pain, tremors, and some nausea. Like you, my emotions are dysregulated, especially in the late afternoon.
I'm hoping my latest blood test shows some improvement in my liver enzymes, so I can at least feel like all the suffering has been for something.
I, too, would like to hear some success stories. I have a great support system, and talk to a therapist once a week. I'm lucky that I'm newly retired, so I can stay home to deal with this.
I hope things improve for all of us soon. It's all very scary because of all the unknowns.

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I forgot to mention that I was prescribed Gabapentin off-label for the anxiety. I take 300 mg twice a day, and 600 mg to help with sleep at night. This has taken the edge off a bit. It's not perfect, but I'll take any relief I can get right now.

REPLY
Profile picture for vicdenlee @vicdenlee

I need encouragement and hope from those who have experienced side effects from tapering off effexor and how long you were on it, how long it took to taper and how long it took for all side effects to go away!
I am struggling to stay motivated and encouraged to push myself to move through the day! I am anxious when I wake and anxious when I go to bed. I am journaling, praying and trying to use MUSE for relaxing/calming my breathing due to anxiousness. I have an appointment with a psychiatrist, but it is a month away due to availability.
I discontinued the effexor after tapering off 75mg after 17 years due to some increased side effects I was concerned about. I was originally put on it when I experienced some peri-menopause symptoms--extreme night sweats, moodiness, anxiety and panic attacks in my late 40's.
After the last day of tapering(a very short taper unfortunately as the doc I saw convinced me my dose was so low all these years that the side effect would be minimal if non-existant.). I experienced terrible flu symptoms--nauseousness, chills, sweats, dizziness, headache, lack of concentration, etc. Luckily the headaches went away and after 8 weeks I now feel like I can concentrate some better. The chills and sweats are lighter and not as frequent. The nauseousness is not good. My husband baked oatmeal scotchies this morning and the sweet surgary smell made me gag! I am mostly anxious--what will go wrong, how to relax? I feel like I need something to tone this down but not sure what to ask for. Doc suggested yesterday, I combined hydrochloride and busipar to relieve the symptoms. Not sure I trust him since he said I wouldn't have any side effects and didn't want to listen to my concerns about withdrawal side effects in the first place. Even the pharmacist I spoke with indicated my dose was so low it would be really easy to taper off. I am sleepy but don't want to go to sleep during the day so I can make sure I sleep at night.
I was crying quite frequently at almost anything sad, even thinking anything sad. Emotions are dysregulated. I am trying to exercise more, drink more fluid, take my vitaming D which is extremely low due to being on the effexor so long.
Today, I filled out a bunch of paperwork and felt pretty good glued to the chair and concentrating on getting it done, but the minute I knew I needed to make lunch or get up to interact with others, or just think about the symptoms of this withdrawal, I become anxious and lose concentration.

Jump to this post

I've been in a similar position as you, however I wasn't on Effexor nearly as long. It's a nasty beast to come off of at any rate, however. The only thing that helped me was when a doctor prescribed me a 30 day regimen of Prozac. After taking it for 3 days my symptoms subsided, and when the 30 days of Prozac was done I discontinued it with little to no side effects. I'm so sorry you're going through this, and I hope that you're able to find a solution.

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