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Palmitoylethanolamide (PEA): Anyone had success?

Posted by wisfloj @wisfloj, Jan 26, 2020

Palmitoylethanolamide (PEA) user for at least 6 months. Seemed to work after several weeks, then not, then somewhat, now not at all and the burning pain is spreading to most of my body. Anybody find success? Is this how it works for you as well? Just hate to throw away money and continue unnecessary/ ineffective supplements. I use the Ergomax brand.
Thank you fellow sufferers! Appreciate this forum and people willing to share, advise and encourage!

Interested in more discussions like this? Go to the Neuropathy Support Group.

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stellarg | @stellarg | Nov 11, 2024

I tried the first 300 mg dose last evening but was awakened about 6 hrs. later with severe itching on both lower legs and ankle areas...I don't know if cause/effect applies. Has anyone else experienced similar PEA side effect?

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6 replies
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rashida | @rashida | Nov 11, 2024
In reply to @stellarg "I tried the first 300 mg dose last evening but was awakened about 6 hrs. later..." + (show)
Profile picture for stellarg @stellarg

I tried the first 300 mg dose last evening but was awakened about 6 hrs. later with severe itching on both lower legs and ankle areas...I don't know if cause/effect applies. Has anyone else experienced similar PEA side effect?

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@stellarg what is PEA?

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stellarg | @stellarg | Nov 12, 2024
In reply to @stellarg "I tried the first 300 mg dose last evening but was awakened about 6 hrs. later..." + (show)
Profile picture for stellarg @stellarg

I tried the first 300 mg dose last evening but was awakened about 6 hrs. later with severe itching on both lower legs and ankle areas...I don't know if cause/effect applies. Has anyone else experienced similar PEA side effect?

Jump to this post

PEA (palmitoylethanolamide) is an oral supplement someone else had mentioned as working 60-70% at relieving
his neuropathy pain. Of course I couldn't find his comment after using it. There are a few vendors on Amazon which is where I bought it after reading of it here.

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2 replies
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stellarg | @stellarg | Nov 12, 2024
In reply to @stellarg "PEA (palmitoylethanolamide) is an oral supplement someone else had mentioned as working 60-70% at relieving his..." + (show)
Profile picture for stellarg @stellarg

PEA (palmitoylethanolamide) is an oral supplement someone else had mentioned as working 60-70% at relieving
his neuropathy pain. Of course I couldn't find his comment after using it. There are a few vendors on Amazon which is where I bought it after reading of it here.

Jump to this post

I used 1 300mg cap and had the severe itch in both lower legs and ankles. Thanks for your inquiry.
Tom B.

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ohiodoug | @ohiodoug | Nov 13, 2024
In reply to @stellarg "I tried the first 300 mg dose last evening but was awakened about 6 hrs. later..." + (show)
Profile picture for stellarg @stellarg

I tried the first 300 mg dose last evening but was awakened about 6 hrs. later with severe itching on both lower legs and ankle areas...I don't know if cause/effect applies. Has anyone else experienced similar PEA side effect?

Jump to this post

I've been taking 1100 mg PEA for last six months in combo with another vitamin regiment (The Protocol).
Overall, my pain is better.

I get my PEA from https://thewelltheory.com/

There is research supporting PEA treating neuropathy so its worth trying! For example...

Palmitoylethanolamide in the Treatment of Chronic Pain: https://pmc.ncbi.nlm.nih.gov/articles/PMC10053226/

Effect of PEA-OXA on neuropathic pain
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1303-5
Good luck!
Doug

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1 reply
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stellarg | @stellarg | Nov 13, 2024
In reply to @ohiodoug "I've been taking 1100 mg PEA for last six months in combo with another vitamin regiment..." + (show)
Profile picture for ohiodoug @ohiodoug

I've been taking 1100 mg PEA for last six months in combo with another vitamin regiment (The Protocol).
Overall, my pain is better.

I get my PEA from https://thewelltheory.com/

There is research supporting PEA treating neuropathy so its worth trying! For example...

Palmitoylethanolamide in the Treatment of Chronic Pain: https://pmc.ncbi.nlm.nih.gov/articles/PMC10053226/

Effect of PEA-OXA on neuropathic pain
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1303-5
Good luck!
Doug

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Thanks for the references ohiodoug. I'm still leary of using PEA after my severe itching episode from one XGold Health 300mg . May try another brand after a short break.
The Indians (Guardians) will get 'em next year. Go tribe!

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jchet | @jchet | Nov 13, 2024
In reply to @stellarg "PEA (palmitoylethanolamide) is an oral supplement someone else had mentioned as working 60-70% at relieving his..." + (show)
Profile picture for stellarg @stellarg

PEA (palmitoylethanolamide) is an oral supplement someone else had mentioned as working 60-70% at relieving
his neuropathy pain. Of course I couldn't find his comment after using it. There are a few vendors on Amazon which is where I bought it after reading of it here.

Jump to this post

Be Careful. I ordered PEA from Amazon, but will return it as I found out that you should not take it if you’re on Eliquis (blood thinner).

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3 replies
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stellarg | @stellarg | Nov 13, 2024
In reply to @jchet "Be Careful. I ordered PEA from Amazon, but will return it as I found out that..." + (show)
Profile picture for jchet @jchet

Be Careful. I ordered PEA from Amazon, but will return it as I found out that you should not take it if you’re on Eliquis (blood thinner).

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Thanks for the input, jchet. I do take coumadin the old school blood thinner and have not checked with my cardiologist yet. Sometimes I DO get the correct, safe sequence for meds, which makes old age so much more fun.

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Moderator
Colleen Young, Connect Director | @colleenyoung | Nov 29, 2024
In reply to @stellarg "I tried the first 300 mg dose last evening but was awakened about 6 hrs. later..." + (show)
Profile picture for stellarg @stellarg

I tried the first 300 mg dose last evening but was awakened about 6 hrs. later with severe itching on both lower legs and ankle areas...I don't know if cause/effect applies. Has anyone else experienced similar PEA side effect?

Jump to this post

@stellarg and others, you may also be interested in this related discussion:
- Palmitoylethanolamide (PEA) supplement: Success with Pain & Sleep? https://connect.mayoclinic.org/discussion/pea-supplement/

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ohimsick | @ohimsick | Mar 12, 2025
In reply to @margaretob "Just started on Gabapentin @ night for leg cramps. DOES NOT HELP.....will see a NEUROLOGIST on..." + (show)
Profile picture for margaretob @margaretob

Just started on Gabapentin @ night for leg cramps. DOES NOT HELP.....will see a NEUROLOGIST on Tuesday. Diabetes since May 1995, on insulin ..Pain in left leg that moves around, lack of sleep, sugar jumping up for no reason on no food. Need to knock it down @ 2 a.m. fierce pain.

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If you have Neuropathy and have not used Alpha Lipoic Acid, you need to try it. It's usually 600mg per capsule. Use 1-2 capsules. I have found this to be 90-100% effective, if you aren't to far gone. I use ALA by (Bulk Supplements). It works in an hour. Very effective

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