Anyone using PEA supplement for pain inflammation sleep? Success. Failures
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@akalsas – Every day I hear or learn something new on Connect! Until you post, I had never heard of PEA (full name Palmitoylethanolamide)
This paper explained a lot:
It states u=in the summary. "(PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management."
There are over 300 studies of the benefits and safety of PEA – I have only read bits of a few so far, but the news is almost universally positive.
But….as always, the devil is in the details. It has proven difficult to achieve and maintain a therapeutic level due to its nature. From the same article, "PEA is lipophilic in nature and almost insoluble in water , and its poor solubility and bioavailability has limited the development of nutraceutical applications."
There is one promising method, "The novel crystalline dispersion technology (LipiSperse® [Pharmako Biotechnologies Pty Ltd., Frenchs Forest, Australia]) uses a combination of surfactants, polar lipids and solvents to increase the wettability of lipophilic substances in aqueous environments . By embedding amphiphiles into the surface of lipophilic molecules, LipiSperse® decreases the contact angle with water, reduces the surface tension between particles and acts as a dispersing agent. The prevention of agglomeration increases the specific surface area of the lipophilic substance in the GIT, thus enhancing absorption." (The authors of this paper are just reviewing other studies, so I don't think there is any conflict in promoting this method.)
They stress the need to understand that the benefits are short-term (a few hours) compared to longer term (all night or all day)
PEA is also found in egg yolks, meat soybeans, peanuts and some other lugumes. So any decision to use a PEA supplement must be accompanied by a diligent search to find a quality product. I do not know if any on the market use the patented LipiSperse technology.
What does anyone else know about this interesting topic?
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I’ve been taking PEA made by Mirica, a brand sold on Amazon. It says it uses the technology you mention. I have problems with my back, I’m just now recovering from a fusion at L5-S1; my MRI tests showed I have a Tarlov cyst at S2 level. This PEA was mentioned in a forum I followed online, a few people said to take it daily for help with the pain. I don’t know if it’s helping yet, but I’ve committed to trying it for the next year.
What is the company that sells your pea!
Hi @akalsas. You mentioned you are curious about this supplement for inflammation and sleep. If you are comfortable sharing, what is causing your inflammation?
Have 2-3 Hypnic headaches nightly which means no solid sleep ever. Since cause of these headaches is not known looking for answers
Yes some use it
Thanks for posting this. Like you, it’s the first I have heard of it. I am very interested.
Can you share the Facebook Group?
What is the name of your Facebook group mentioned? Thank you.
I took PEA supplement from Neurobiologix for several years (2x/day ) thinking it helped with my sleep and nerve pain. However, I recently went off it and have found no difference, so am not convinced of its effectiveness.
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