Have you had low blood pressure on Zepbound? Advice?

Stopped Zepbound at the end of June, off blood pressure meds and dealing with bouts of orthostatic hypotension. Wish I had something positive to say about this issue. Stay hydrated and try compression hose.

During my 2nd week on Zepbound began to have drastic BP drops causing severe light-headedness to almost passing out. Literally spent most of time lying down cause nothing helped. Never once related it to Zepbound, but saw Dr. today and she said it was the Zep. She’s taking me completely off the BP meds for 4 wks., then will reassess. (I’ll post result after 4 wks.)

We think the doctor was making professional decisions based on experience he'd already gotten from others with the same condition. The name of the product is Semiglutide. She stopped the Semiglutide immediately after visiting with her doctor, refrained from driving for 6 months and has been taking Topomax since and she's had no other events. It seems the doctor knew what he was doing. The event frightened her 10 year old boys. They found her unconscious in her closet. She did not have Status E. I appreciate your interest

Hi @royanthony - so, did your stepdaughter's doctor consider the focal seizures to be side effects of the weight loss shots, or unrelated and indicative of something else going on? What kind of weight loss shots was she taking?

@lisalucier My step daughter was using a weight loss shot. She experienced 2 focal seizures and is now on Topomax for caution. The seizures are not genetic related as she is my step daughter.

You said you’ve had high BP for years so I assume you were taking meds. Are you still taking medicine for your BP? We decreased mine then finally discontinued my BP meds. There were no further problems. I took my BP 3x day for a month before my cardiologist visit so he would have the info he needed to make a decision. Good luck!

I had the same. I told my PCP . I was taking Atenolol 25 mg bid. I couldn’t stand it. So I skipped my nightly meds. I send my vitals into my PCP. She said now have normal BP. Hmmm.

No clue. Im on a Mediterrean diet. I eat food without labels. I do yoga, Pilates , dumbbells- guess I could swim or something...

Hi @gwenrn74 - you're right. I was responding to @meali who is having issues with her blood pressure while on tirzepatide (Zepbound).

You received the email notification when I responded to @meali because I @mentioned you to bring you into the discussion to share your experiences with tirzepatide (Zepbound), hoping you might have some helpful tips for meali. See her discussion here:
Zepbound and low blood pressure https://connect.mayoclinic.org/discussion/zepbound-and-low-blood-pressure/

gwenrn74, I had some plateaus when I was taking semaglutide (Wegovy), and I struggled sometimes to figure out why. What do you think has made you plateau in your tirzepatide (Zepbound) journey? Did your prescribing doctor have any thoughts on that or what you might do next?

@meali I responded to myself Lolol Check out my response