Would love to hear opinions

Posted by koleke @koleke, 1 day ago

My question is, "Has anyone been on amiodarone for an antiarhyhmic medication. And did it work for you? "
I am in the "blanking period" from an ablation I had on June 9. I was having symptoms of fatigue and constantly having to get up during the night for a bathroom trip. I called my cardiologist and they put me on 200 mg of amiodarone twice a day saying they were loading my body so my heart would heal. They did a cardio version on Monday which did nothing, but cost me a fortune. Now they want me to stay on the high loading dosage for at least another month. What would you do? Has anyone experienced something like this? I live in a rural area and am thinking I need to go to a larger university hospital.

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If you research it you might find that amarodione works but is very powerful. Doctors get you off it asap. It does damage to other organs.
To load you up with so much for so long doesn't sound good.

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We need some elucidation.

What is the loading dose?

Why was THE most powerful anti-arrhythmic drug prescribed and at such a high dose?

Have you had the post-ablation Holter assessment? What were the results communicated to you?

For a physician to prescribe amiodarone, you would have to have clear indications of arrhythmia. So, WERE you in arrhythmia or just feeling blaaah?

It seems odd to me, but I don't know your case or history. I don't know what the amiodarone is meant to forestall. Usually in a blanking period with a cranky heart the patient is put on a maintenance dose of diltiazem, metoprolol, propafenone, and/or flecainide (a blocker/rate control plus an AAR like propafenone or flec) However, I was never given any of those post ablation, only amiodarone, and only because my heart went haywire at the six day mark post ablation. I was loaded at 800 mg for a week (400 BID), and then maintained at 400 daily (200 BID) for five weeks. After that, I was to do a two-week taper with one 200 mg tablet taken some time during the day.

I don't understand why the need for you to take a 'loading dose' for an entire month. Seems excessive, but I am untrained, unqualified, and don't know you.

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It is relatively common to experience A.Fib in the early weeks after an Ablation. Whichever method of ablation you had, the intent is to cause scar tissue to develop in your heart such that it acts like a wall that will block the travel of the potential fibrillatory currents. Also, the specific trigger sites near the outlet of the pulmonary veins entering your atrium, these also need time to develop scar. The success of a cardioversion is probably about 50%, but it's always worth a try because we are all better off in Sinus Rhythm. The Amiodorone is a good drug for your situation and in due time, perhaps it won't be necessary. Every single person undergoing an ablation, is unique and ultimately your medical team seeks the best outcome. Whatever you do; do not stop taking the anti-coagulation drug. If you are having any unexpected bleeding contact your doctor right away.

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Profile picture for gloaming @gloaming

We need some elucidation.

What is the loading dose?

Why was THE most powerful anti-arrhythmic drug prescribed and at such a high dose?

Have you had the post-ablation Holter assessment? What were the results communicated to you?

For a physician to prescribe amiodarone, you would have to have clear indications of arrhythmia. So, WERE you in arrhythmia or just feeling blaaah?

It seems odd to me, but I don't know your case or history. I don't know what the amiodarone is meant to forestall. Usually in a blanking period with a cranky heart the patient is put on a maintenance dose of diltiazem, metoprolol, propafenone, and/or flecainide (a blocker/rate control plus an AAR like propafenone or flec) However, I was never given any of those post ablation, only amiodarone, and only because my heart went haywire at the six day mark post ablation. I was loaded at 800 mg for a week (400 BID), and then maintained at 400 daily (200 BID) for five weeks. After that, I was to do a two-week taper with one 200 mg tablet taken some time during the day.

I don't understand why the need for you to take a 'loading dose' for an entire month. Seems excessive, but I am untrained, unqualified, and don't know you.

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@gloaming loading dose is 200 mg twice a day. I was only prescribed the drug when I called and complained about fatigue 3 weeks post ablation. My doctor went on vacation and I still have not spoken to him. Everything is being decided through a PA and the cardiologist who did my recent cardioversion. I don't see my actual doctor for four weeks. I had an ablation in 2022 that lasted four years. It was with heat. This one was the new one l, the pulse field ablation. I'm just going to follow orders and pray my heart listens to the medicine.

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Profile picture for koleke @koleke

@gloaming loading dose is 200 mg twice a day. I was only prescribed the drug when I called and complained about fatigue 3 weeks post ablation. My doctor went on vacation and I still have not spoken to him. Everything is being decided through a PA and the cardiologist who did my recent cardioversion. I don't see my actual doctor for four weeks. I had an ablation in 2022 that lasted four years. It was with heat. This one was the new one l, the pulse field ablation. I'm just going to follow orders and pray my heart listens to the medicine.

Jump to this post

@koleke Thanks for that. I still don't like the idea of you being on amiodarone if you aren't experiencing ectopy or AF/AFL (atrial fibrillation or atrial flutter). But, that's just uneducated me....what I missed was that you had a cardioversion? When? And for what? It was a cardiologist who agreed to perform that procedure, so I'm guessing he/she found your heart to be in an arrhythmia...

When I had a rough time shortly after my second ablation, about two weeks later, I was given a bolus of metoprolol, and no cardioversion was attempted. The internist explained that I had failed on three recent cardioversions, so they didn't feel it was likely to work. When I told that to my EP's outreach nurse, she was very emphatic that the ER team did exactly the wrong thing. Every time a heart undergoes an ablation, it's like a reset. Many EPs, including mine, will routinely cardiovert the patient before releasing them from the cath lab. After they have blunted the rogue signals and the job appears to be done, the heart is newly in NSR, patient blissfully sleeping, they cardiovert and wheel the patient out to recovery. So, if your heart begins to act up in the blanking period later, a cardioversion is THE thing to do. Lucky for me, my heart accepted the bolus and I converted back to NSR that evening..................and have been in NSR ever since. Thirty-eight months now.

As for the 200 mg twice a day, and I hasten to remind that I am uneducated in medicine, my experience was 400 twice a day. Maybe it has to do with body weight, or other conditions that I'm not aware of....but it seems like a stingy dose for loading. On the other hand, these people should know what they're doing, and maybe they know from experience that someone in your circumstances will/should do rather well on that lower initial dose. I guess we'll just have to wait and see.

I hope it works out well, that you can unlax a bit, feel better, and that you get over this rough patch. If the worse comes out to the worst, you can always have a second ablation. Happened to me, seven months after the first. About 25% of all index ablations fail, but happily the probability for a success is considerably higher for a second attempt.

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Your instincts are spot on. Get to a larger well-renowned hospital for a second opinion, even if it turns out that they changed nothing. It would serve to ease your understandable concerns.

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I would ask what other prescription drugs and even supplements you are also on.

I have no direct experience with ablations or serious drug treatments for arrhythmias, the only prescription I've ever had for it is a little beta blocker, which helped a bit, and I was probably grossly undertreated for several years. Eventually I seemed to beat it, somehow, possibly with diet, and now with that same minor beta blocker it is about 99% better.

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