1. < Osteoporosis & Bone Health
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Why me? (sorry for the childish question)

Posted by tybalt98 @tybalt98, Jul 10 9:07pm

I've always been healthy. I'm 77 yo female; started running in 1980 and continued up until about 4 years ago. I mean serious running, 6 miles 5 days a week until I was about 60. I had a medical hysterectomy at 32 and was on HRT until I was about 65. I can't remember why I stopped. But I'm happily married for 43 years, so I use Premarin Vaginal Cream regularly. I hate when people ask "why?" but I have to ask. Why do I have an osteoporosis diagnosis? My endo wants to put me on Forteo. I'm leary because of all the negative posts on reddit. Does anyone think I caused Osteoporosis by running so many years? I was never anorexic and literally never really sick.
Also, I'm new here; please forgive my ignorance and be kind.

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njx58 | @njx58 | Jul 17 5:47am
In reply to @roseincalifornia "@njx58 Your improvements from Tymlos are amazing. What follow-up drug therapy are u doing? are you..." + (show)
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@njx58 Your improvements from Tymlos are amazing. What follow-up drug therapy are u doing? are you still seeing bmd gains post-tymlos? Bmd is supposed to continue to rise a little the 1st 2 years on reclast ...

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@roseincalifornia I am on Fosamax. No issues. My bone markers (P1NP, CTX) did get "worse" in a way, but that is expected when you're no longer on Tymlos. P1NP is going to go down. CTX is still in a good range relative to P1NP.

I started this in Janaury, so I'm not due for a DEXA for another six months.

I did have the option of doing Reclast, but I said "no way" to an infusion. An infusion is like jumping out of a plane and hoping your parachute is properly packed. If not, there's no turning back! 🙂

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rashida | @rashida | Jul 17 6:30am
In reply to @njx58 "@roseincalifornia I am on Fosamax. No issues. My bone markers (P1NP, CTX) did get "worse" in..." + (show)
Profile picture for njx58 @njx58

@roseincalifornia I am on Fosamax. No issues. My bone markers (P1NP, CTX) did get "worse" in a way, but that is expected when you're no longer on Tymlos. P1NP is going to go down. CTX is still in a good range relative to P1NP.

I started this in Janaury, so I'm not due for a DEXA for another six months.

I did have the option of doing Reclast, but I said "no way" to an infusion. An infusion is like jumping out of a plane and hoping your parachute is properly packed. If not, there's no turning back! 🙂

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@njx58 what is PINP and CTX.

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roseincalifornia | @roseincalifornia | Jul 18 11:04am
In reply to @rashida "@njx58 what is PINP and CTX." + (show)
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@njx58 what is PINP and CTX.

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@rashida

Your body constantly remodels bone tissue using two primary cell types: osteoblasts (bone builders) and osteoclasts (bone clearers).

PINP (Procollagen type I N-propeptide): The "Building" Marker
What it is: A byproduct released into the bloodstream when osteoblasts deposit new type I collagen to form bone.
Significance: It serves as the primary clinical marker for bone formation. High levels indicate active or rapid bone building.

CTX (C-terminal telopeptide): The "Breakdown" Marker
What it is: A fragment of type I collagen released into the blood when osteoclasts dissolve and reabsorb old bone tissue.
Significance: It serves as the primary clinical marker for bone resorption (breakdown). High levels mean bone is being stripped away quickly.

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