Depression: What medication can I try after so many years?

Posted by miray67 @miray67, Apr 22 12:21pm

I have fought depression and anxiety since I was about seven years old when I had panic attacks. Without revealing my age what can you take when you have tried all the older medicines? It’s been with me for MANY years. Not the panic attacks but long spells of depression and anxiety to the point I am ver shaky most of the time. I’m sure there newer medications than the ones doctors want me to try again. I am now on Paxil again after trying it back in 1995. Seems it does everything except what it’s supposed to do. My present doctor refuses to change it but has reduced the dosage again to 25mg from 37.5. I hate to keep changing doctors and trying over and over. Being confined for so long hasn’t helped, of course. I am in good health for my age, still drive a little and do most everything for my self with weak need and chronic pain.

@lilypaws

@gailb Yes, I gained weight because of Tymlos to make more bone. Also, this Covid-19 has left me in front of my computer and not much activity. I have gained 11 pounds. My endocrinologist said because of my side effects I could go off of it for 2 weeks, but my surgeon said if I went off of it they would have to reschedule my surgery. I'm keep on Tymlos, by surgery is June 9th and I have been waiting a long time. Prayers for me would be welcomed. It's a long surgery.

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@gailb My prayers are with you. You got this.

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@lilypaws

@gailb Yes, I gained weight because of Tymlos to make more bone. Also, this Covid-19 has left me in front of my computer and not much activity. I have gained 11 pounds. My endocrinologist said because of my side effects I could go off of it for 2 weeks, but my surgeon said if I went off of it they would have to reschedule my surgery. I'm keep on Tymlos, by surgery is June 9th and I have been waiting a long time. Prayers for me would be welcomed. It's a long surgery.

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@lilypaws Please know that all of MayoClinicConnect is fully behind you with our thoughts and prayers!

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@lilypaws

@gailb Yes, I gained weight because of Tymlos to make more bone. Also, this Covid-19 has left me in front of my computer and not much activity. I have gained 11 pounds. My endocrinologist said because of my side effects I could go off of it for 2 weeks, but my surgeon said if I went off of it they would have to reschedule my surgery. I'm keep on Tymlos, by surgery is June 9th and I have been waiting a long time. Prayers for me would be welcomed. It's a long surgery.

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@lilypaws– Best of luck to you! My longest surgery was 7 1/2 hours! You'll probably lose the weight after your surgery!

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@lilypaws Prayers from around world now till rehab

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@sandij

Vraylar didn't work for me due to the side effects of severe muscle pain. I am now trying lamictal in addition to effexor

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Anyone who is having trouble with the side effects of meds or with meds that are not working for you should look into gene testing. Often times drugs don't work or have too many side effects because you can't metabolize them. Your particular make up the chemistry of your system, won't let the drugs work. There's a company called Genesight Testing and Mayo Clinic has their own form of gene auditing now as well. Not only will this testing tell you which drugs you would be able to metabolize best it can also tell you if your body will metabolize them too quickly leading too underdosing or metabolize them to slowly leading to overdosing.

It doesn't matter if your doctor is registered with Genesight or not. You go to their website and you put in your zip code and they will give you a list of doctors who have taken the 15 minutes on the phone for free to register with the Genesight company. This is what I had to do . I made an appointment with and visited a doctor on their list.
She gave me a cheek swab. When it was tested in return I went back to see her and she explained the report to me. Once I had my report I took it to my doctor and we adjusted my meds accordingly. That report is now a part of my permanent medical record and I have a copy as well If my doctor had been unwilling to look at my report or respond to my report I would have found a new doctor. Many doctors are under so much pressure that 15 minutes on the phone means that's one or two patients they can't see. I guess some doctors don't believe in the testing or have egos too large to allow the metric like this to suggest what they should prescribe for their patients.

The testing relates to three classes of drugs. Psychotropic meds for mental illness, antidepressants, and analgesics or pain meds.

The days of bouncing around from one drug to another trying to find one that works for you should be over. I don't know for a fact that this testing is perfect but it was perfect for me and for my son. Mine was covered by my insurance my son's was covered by his MA. I believe the most you can pay out-of-pocket is $360 but I could be wrong about that. If I had to pay that much I would still say, cheap at twice the price. I don't know what Mayo Clinic does but I know that the GeneSight company has a sliding fee scale.

The burden of having these conditions which we need to have treated is burden enough. We don't need to have it complicated by having to play guessing games to find out what we should be treated with.

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@wsh66

Anyone who is having trouble with the side effects of meds or with meds that are not working for you should look into gene testing. Often times drugs don't work or have too many side effects because you can't metabolize them. Your particular make up the chemistry of your system, won't let the drugs work. There's a company called Genesight Testing and Mayo Clinic has their own form of gene auditing now as well. Not only will this testing tell you which drugs you would be able to metabolize best it can also tell you if your body will metabolize them too quickly leading too underdosing or metabolize them to slowly leading to overdosing.

It doesn't matter if your doctor is registered with Genesight or not. You go to their website and you put in your zip code and they will give you a list of doctors who have taken the 15 minutes on the phone for free to register with the Genesight company. This is what I had to do . I made an appointment with and visited a doctor on their list.
She gave me a cheek swab. When it was tested in return I went back to see her and she explained the report to me. Once I had my report I took it to my doctor and we adjusted my meds accordingly. That report is now a part of my permanent medical record and I have a copy as well If my doctor had been unwilling to look at my report or respond to my report I would have found a new doctor. Many doctors are under so much pressure that 15 minutes on the phone means that's one or two patients they can't see. I guess some doctors don't believe in the testing or have egos too large to allow the metric like this to suggest what they should prescribe for their patients.

The testing relates to three classes of drugs. Psychotropic meds for mental illness, antidepressants, and analgesics or pain meds.

The days of bouncing around from one drug to another trying to find one that works for you should be over. I don't know for a fact that this testing is perfect but it was perfect for me and for my son. Mine was covered by my insurance my son's was covered by his MA. I believe the most you can pay out-of-pocket is $360 but I could be wrong about that. If I had to pay that much I would still say, cheap at twice the price. I don't know what Mayo Clinic does but I know that the GeneSight company has a sliding fee scale.

The burden of having these conditions which we need to have treated is burden enough. We don't need to have it complicated by having to play guessing games to find out what we should be treated with.

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@wsh66 I have read yours and other's posts on Gene sight testing. I went to a psychiatric nurse and she did the testing and sent it to the lab. I am told "You failed" Obviously no good/bad or otherwise drug came up that would be of good benefit to any other drug. What the heck. I am now on Vraylar. I took 1 1.5 capsule on Wed. May 20 and was told not to take another for 4 days. I took another yesterday May 31. She said she wanted to allow the medication to get slowly into my system. I get that because I have been sooo sick coming off Effexor, put on Triifix , going off 5mg of Lexapro, going on 0.5 Klonapine. During this time -2 months- I have been so ill. My doctor put me on Carafate as stomach and esophagus pain is killing me. I have dry heaves at the drop of a hat.I had stomach surgery 10 years ago because acid reflux was eroding my esophagus and this is why I can't actually vomit stomach contents. Dry heaves so painful. Any input will be appreciated. This psychiatric nurse was referred by a counselor and has a good reputation as far as I can see. I was so excited when she asked to do the Gene sight test. Well. that was another bummer..

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@summertime4

@wsh66 I have read yours and other's posts on Gene sight testing. I went to a psychiatric nurse and she did the testing and sent it to the lab. I am told "You failed" Obviously no good/bad or otherwise drug came up that would be of good benefit to any other drug. What the heck. I am now on Vraylar. I took 1 1.5 capsule on Wed. May 20 and was told not to take another for 4 days. I took another yesterday May 31. She said she wanted to allow the medication to get slowly into my system. I get that because I have been sooo sick coming off Effexor, put on Triifix , going off 5mg of Lexapro, going on 0.5 Klonapine. During this time -2 months- I have been so ill. My doctor put me on Carafate as stomach and esophagus pain is killing me. I have dry heaves at the drop of a hat.I had stomach surgery 10 years ago because acid reflux was eroding my esophagus and this is why I can't actually vomit stomach contents. Dry heaves so painful. Any input will be appreciated. This psychiatric nurse was referred by a counselor and has a good reputation as far as I can see. I was so excited when she asked to do the Gene sight test. Well. that was another bummer..

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This is a new one on me. Did you contact the company to ask what you failed meant? What did your doctor say about that conclusion? Could it be that they didn't get a good sample to test? I'm going to look into this myself and find out what it means.

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@wsh66 Thank you for taking an interest in this. What I understood her to say and that just any medicine for me. Nothing stood out. I don't get it either. I do have the test results on my computer and need to fix my printer to get them off. In this small, very limited town I live in. no one even heard of Gene testing.

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@buyearly

I, too, suffered from depression/anxiety for decades until God led me to the right Dr. for me, a NeuroPsychiatrist, she correctly diagnosed my problem (Bipolar) and prescribed the correct med for me (Lithium, had to be brand name of Lithobid). I'm very sensitive to meds! She stuck with me and worked with me–that's very important in your doctor. The only other thing which I sense you are doing, is to never quit taking a med unless you talk to your Dr. first. I know from my exp. that God will see you through this–Pray and I will pray, too. I've been been taking my med and symptom free 33 years! Bless you!

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My brother developed stage four kidney failure from using Lithium for many years. I was on it for some time. Them several years ago I switched doctors. He said I must go off of it because of it's affect on kidneys.

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GeneSight testing

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miray @miray 67 I am sorry to hear you have the problems that you have. There is a drug that is used as a pain killer and an antidepressant. I take it for depression My mother used it for both pain and depression.. The drug is Cymbalta (brand) aka duloxetine (generic)

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When I heard a drug for pain and depression I thought you were going to say amitriptyline. I take it at night for the pain caused by the combination of neuropathy and high compression on my left leg which I have to do. I can only tolerate 25 mg as it is also a powerful sleep aid. I took Cymbalta but not for long. Did nothing for pain and it made me distinctly suicidal so much so that it wasn't even scary because it was obviously a drug effect. I don't guess the drugs anymore yes. I had genesight testing so now I know what pain drugs will work best for me as well as drugs for depression or other mental issues. The testing can tell you based on your genetic makeup which of these drugs your body can properly metabolize and the rate that you will metabolize these drugs at. It seems this is a large part of the battle of finding the right drug.

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