UTI or urinary retention and inhalers

Posted by mchristmas @mchristmas, Dec 5, 2020

Anyone experience having re occurring utis due to starting inhalers. I was diagnosed with asthma this year and I’ve tried 3 different inhalers with long breaks in between and each time I get an awful uti or urinary retention symptoms. At this point my utis are becoming antibiotic resistant. On research studies it says it happens with inhalers containing ipratropium and salbutamol. My pharmacist believes it’s because of the steroid in the inhaler but my urologist and allergist haven’t run into this problem before. Does anyone know of names of inhalers that I could use that won’t cause this problem?

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Profile picture for elaine21 @elaine21

I’m very worried of using Tezspire. Looking into the medicine it only has been out since 2022, therefore, they don’t have enough data to say what the side effects are. I don’t have COPD nor asthma. I do have allergies and get monthly shots, but my chronic cough does not go away. As you, they want to do a sleep apnea study. I don’t see how that’s going to cure my chronic cough. So frustrating!

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Do the sleep study, but make sure they test for hypo ones..(low oxygen levels when you sleep).
After 6 sleep studies someone finally decided to have a pulse ox monitor attached monitoring throughout the study. They found I barely slept, but every time I did my o2 levels crashed. Now that they have me on oxygen during the night.. no more morning headaches and feeling drained.
It all can be a pain in the butt or daunting, but the diagnosis & management.. it can add years to your life & prevent other problems in the future.

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Profile picture for rowun4 @rowun4

Update: Tezspire injections started. But took 5 months after insurance prior authorization went through. No one told me that insurance would pay for it. Why? The doc’s practice didn’t want to pay for it first & get reimbursed. So all the infections & steroids during the summer were because of MONEY. I was told quietly by a nurse that if it didn’t kick in by 6 months it might never will. I just had my 5th dose. O2 keeps going down. No recent steroid use. But now it’s been 2 months since he tried to push through a script for a new rescue inhaler.
OY!! Word of advice to anyone: chase it. No one at the insurance company gave me the direct response (started in May ‘23) until August. Had to squeeze everyone & play dumb at judicious times to get to a supervisor type to explain.. I have another “situation” that is going to make things worse, gotta get surgery. Oh, & try a sleep study. They’ve tried helping my breathing (sarcasm here), & just finished figuring out my O2 levels were dipping into low 80s when I slept. After 6 sleep studies. Sorry for TMI.. just tired.
Thanks for reading this all if u did. Hopefully something helps someone.

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I’m very worried of using Tezspire. Looking into the medicine it only has been out since 2022, therefore, they don’t have enough data to say what the side effects are. I don’t have COPD nor asthma. I do have allergies and get monthly shots, but my chronic cough does not go away. As you, they want to do a sleep apnea study. I don’t see how that’s going to cure my chronic cough. So frustrating!

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Muscarinic Agonists like ipatropium and tiotropium are known to potentially cause urinary retention.

Yupelri is a different muscarinic agonist that is only via jet nebulizer and NOT supposed to cause urinary retention if your provider wishes you to try it. I took it for a while.

I’ve been taking Dupixent and Trelegy since November 2024 and so far, it’s been a great combo for me. Trelegy does have a muscarinic agonist though, so may be tough for folks prone to urinary tract infections. The combo has helped keep me free of exacerbations.

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Profile picture for Cheryl, Volunteer Mentor @cehunt57

I hate it when a med or treatment for one thing leads to side effects or problems in another area! Have you reported this to your provider? Perhaps there is an alternate med or dose that will alleviate the problem? I wouldn’t just stop the med on my own without seeking advice from the prescribing provider.

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Thank you. I will report to my Pulmonologist next visit but in the meantime, I do have other things that I use for mild asthma wheezing/shortness of breath that do not have side effects. I was really experimenting with the Spiriva for something that would help with nighttime asthma so I would not wake up and need to use a rescue inhaler, Xopenex. That is only periodically and usually when I have eaten a food that I do not tolerate.

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Profile picture for slh5757 @slh5757

I recently developed burning and painful urination. Urine culture came back negative for bacteria. I did not understand. I have tried 3 antibiotics and nothing is helping with what I thought was a UTI. After some investigating online, I made the connection about recently starting a Spiriva Inhaler and my current urinary tract symptoms. I then found Mayo Connect and was so relieved to find that I am not the only one that has experienced urinary tract issues with inhalers. I will be stopping the Spiriva and will pray that this awful burning in my urinary tract will go away.

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I hate it when a med or treatment for one thing leads to side effects or problems in another area! Have you reported this to your provider? Perhaps there is an alternate med or dose that will alleviate the problem? I wouldn’t just stop the med on my own without seeking advice from the prescribing provider.

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Profile picture for Colleen Young, Connect Director @colleenyoung

@jcold5619, you're quite right that the link from WebMD is no longer valid. I have removed it.

Here is a study looking at the relationship between inhaled, long-acting anticholinergic medication (LAA), commonly used for moderate-to-severe chronic obstructive pulmonary disease (COPD) and urinary tract infection (UTI),

- Inhaled Long-acting Anticholinergics and Urinary Tract Infection in Individuals with COPD https://pubmed.ncbi.nlm.nih.gov/27732117/

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I recently developed burning and painful urination. Urine culture came back negative for bacteria. I did not understand. I have tried 3 antibiotics and nothing is helping with what I thought was a UTI. After some investigating online, I made the connection about recently starting a Spiriva Inhaler and my current urinary tract symptoms. I then found Mayo Connect and was so relieved to find that I am not the only one that has experienced urinary tract issues with inhalers. I will be stopping the Spiriva and will pray that this awful burning in my urinary tract will go away.

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I take it AM and PM. If one works that's great!

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Profile picture for km6 @km6

I take Mannos twice a day. You should be able to find it in a good health food store.
It helps prevent uti. And lots of water

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I finally started using it too and so far (9months) no UTI's. I usually had two or more a year, I'm only taking one a day. Is that how you started out?

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Profile picture for budisnothome @budisnothome

Wow. I have a suprapubic catheter and severe uti's about every other month. I have asthma and gave been doing the nebulizer duonebs treatment about every 4 to 5 hours. This conversation had me wondering if the nebs is causing my uti's. May need to study up on this. Cranberry juice is no help. Inhalers don't help me so doc has me doing nebulizer.

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I take Mannos twice a day. You should be able to find it in a good health food store.
It helps prevent uti. And lots of water

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I was having constant recurring uti. That led me to having CDiff because of the antibiotics. I never connected it with the inhaler. I saw a specialist and one of the things they did to help me was to put me on vaginal estrogen, I am 72. That seems to help a lot. I don't know if they do that with younger people.
It seems like every step forward we take there's a side effect.

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