Sibo treatment Rifaxamin and Neomycin

Going to start SIBO antibiotic protocol with rifaximin and neomycin. Has anyone gone thru this and what are the effects/side effects.

Thanks.

Slightly worse stools than normal for about 4 days (this to me signaled that it was working). After four days, reasonable but not great stools for the duration of the treatment. Certainly better than having SIBO. You're supposed to eat all the "bad" foods during treatment in order to get the bacteria to come out of hiding, so eat those foods you've been avoiding, within reason. GL.

Hi @marcconley, You might find some answers to your questions in these related discussions:

-- NEOMYCIN vs. METRODINAZOLE for SIBO: Worried about otoxicity: https://connect.mayoclinic.org/discussion/neomycin-vs-metrodinazole-for-sibo/
-- Questions about Rifaximin: https://connect.mayoclinic.org/discussion/probiotics-after-rifaximin/

I will not take neomycin either. Unfortunately the studies show most SIBO comes back after taking these.
Extreme bloating and feeling horrible are most peoples concerns and symptoms while on them .
Everyone says get to the root. That could be so many things you don’t have control over like repeated antibiotics etc.
a functional Dr wants extreme strict diet to starve the SIBO but a registered dietician will tell you you are restricting too many calories, nutrition and it will come back .
Two GIs say too many false positives even in a hospital lab test for accurate SIBO results.
Some say hit with probiotics some say very little effect.
Then throw in the acid problem and they all want you to take PPI and the long term effects are horrible and very hard to get off of.
If I knew Mayo had the answer I would be there tomorrow. I haven’t read anyones success from them .
I wish I knew.
Keep asking keep pushing you are your best advocate. If you don’t call for apt they assume you feel great!
Not enough good doctors I called my GI and next apt is in February .. 4 months out!!!

Question. Did you get SIBO from IBS or a colectomy? I had a sub total colectomy 7 months ago and am just starting to have symptoms.
I am so happy for you that you have a good team at Mayo. I was considering that option, too.

I took neomycin 2/day for 28 days and it is what finally removed my SIBO after fighting it for over 2.5 years. I would do it again in a heartbeat given how bad my quality of life was. No kidney or hearing damage, but of course your experience could always be different. I would ask your doctor/pharmacist for clarification on what the documented rate of hearing/kidney damage is, what steps you should take to minimize it, and what extenuating factors increase or decrease your chances. Only then are you in a position to make "informed consent".

No, I don't know why I have it. Thanks for asking though.
Wishing you well.

I have taken xifian 6 times never helped.
Afraid to treat with neomycin due to liver and hearing loss possibilities.
Keep asking questions and keep changing to a dr that listens and cares .

Sadly, my insurance has denied the Xifaxin... Has anyone been able to figure out a workaround for this situation?
Thanks in advance.

I was prescribed but didn’t take it due to cost. I have been working with a nutritionist. Good luck.