Site reactions to biologic injections

i’ve been struggling with site reactions to biologic injections for sero-negative RA, which has caused me to fail on a few biologics, in both auto inject and syringe options.

I’ve experienced site reactions to Humira syringe and auto inject., Actema syringe and auto inject, tyene syringe, and now Kevzara syringe. After a few months on each drugs, except the last, I was advised to stop taking them. In fact, I have begun reacting to Repatha injections for hyperlipidemia now, which I took previously without issue for two years.

After four years of frequent medication changes after a run- in a post-Covid in 2022, I have finally found it a biologic that works. My inflammation and pain are much improved.I really need to stay on Kevzara.

My doctor has advised me to take Benadryl an hour before my home injection, and to apply Cortizone cream for the next three days. i’ve been doing this for over a year now, and I still develop a thick site reaction by day two of 4 x 2“.

I am much in need of ideas. I have had sero-negative RA for 31 years and I fear I am running out of options. I’ve got to find a way to stay on Kevzara, which really does appear to manage my RA symptoms well.