Shingrix and peripheral neuropathy

Posted by joannerhodes @joannerhodes, Feb 1, 2019

4 days after my 2nd Shingrix vaccination, I suddenly developed intense peripheral neuropathy in both feet…for the first time in my life…anyone else?

Liked by sunnyflower

Here are some relevant discussion regarding neuropathy medications and gabapentin.
– Neuropathy Medications https://connect.mayoclinic.org/discussion/neuropathy-medications/
– Neuropathy: Anyone have any experience with gabapentin? https://connect.mayoclinic.org/discussion/neuropathy-13/

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lioness, I think my flare ups are mostly due to stress. I have some slight balance problems but think that is due to an ongoing hip problem. I have constant vision blurriness which I attribute to dry eye from the gabapentin, which clears when I blink or use eye drops. I have had other side effects which went away after a while. Helen

Liked by Hank, sunnyflower

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I am now focused on the component of the Shingrix vaccine which may be responsible for developing my Small Fiber Neuropathy. The Medicinal ingredients are: "1 dose (0.5 mL) contains 50 micrograms of glycoprotein E (gE) powder mixed with AS01B adjuvant suspension. gE is a protein found in the Varicella Zoster Virus. This protein is not infectious." "Non-medicinal ingredients: Cholesterol, dipotassium phosphate, dioleoyl phosphatidylcholine, disodium phosphate anhydrous, polysorbate 80, potassium dihydrogen phosphate, sodium chloride, sodium dihydrogen phosphate dihydrate, sucrose and water for injections."

I believe the culprit is the Adjuvant. "There are several possible pathophysiologic mechanisms that may explain vaccine-associated polyneuropathies including including immune-mediated hypersensitivity to the adjuvants or solvents in the vaccine, as well as nervous system invasion caused by prolonged, less virulent, viral infection." "The adjuvant is made of 50 micrograms each of a plant extract (Quillaja saponaria Molina, fraction 21 (QS-21)) and a bacterial extract (3-O-desacyl-4’- monophosphoryl lipid A (MPL)) and is used to improve your body’s response to the vaccine." This is reported to be a very powerful adjuvant.

My questions are: 1. How long does this adjuvant stay active in the body? 2. Can it be neutralized? 3. What is the mechanism causing the neuropathy?
4. What component in the adjuvant is the source of the problem?

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What in your background as a dentist gives you the ability to find "truth"… in the questions your list? Do you have connections with clinical trials of some of the issues or medications..? What is your methodology in finding the answers?

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@ken82

What in your background as a dentist gives you the ability to find "truth"… in the questions your list? Do you have connections with clinical trials of some of the issues or medications..? What is your methodology in finding the answers?

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I will search for scientific evidence and seek out professionals who specialize or have interests in these issues. Hopefully someone will do a study about Shingrix post vaccination small fiber neuropathy. I have already found a neurologist in Chicago who is aware of this being reported. Four years of dental school includes biochemistry, histology & embryology, general anatomy, neuroanatomy, epidemiology & biometry, microbiology, pharmacology, physiology, pathology, internal medicine, pathology, therapeutics, and public health in addition to all of the dental specific courses and labs. Many dental schools have changed the degree from DDS ( doctor of dental surgery) to DMD ( doctor of dental medicine) to reflect the medical education of general dentists.

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@dont

I am now focused on the component of the Shingrix vaccine which may be responsible for developing my Small Fiber Neuropathy. The Medicinal ingredients are: "1 dose (0.5 mL) contains 50 micrograms of glycoprotein E (gE) powder mixed with AS01B adjuvant suspension. gE is a protein found in the Varicella Zoster Virus. This protein is not infectious." "Non-medicinal ingredients: Cholesterol, dipotassium phosphate, dioleoyl phosphatidylcholine, disodium phosphate anhydrous, polysorbate 80, potassium dihydrogen phosphate, sodium chloride, sodium dihydrogen phosphate dihydrate, sucrose and water for injections."

I believe the culprit is the Adjuvant. "There are several possible pathophysiologic mechanisms that may explain vaccine-associated polyneuropathies including including immune-mediated hypersensitivity to the adjuvants or solvents in the vaccine, as well as nervous system invasion caused by prolonged, less virulent, viral infection." "The adjuvant is made of 50 micrograms each of a plant extract (Quillaja saponaria Molina, fraction 21 (QS-21)) and a bacterial extract (3-O-desacyl-4’- monophosphoryl lipid A (MPL)) and is used to improve your body’s response to the vaccine." This is reported to be a very powerful adjuvant.

My questions are: 1. How long does this adjuvant stay active in the body? 2. Can it be neutralized? 3. What is the mechanism causing the neuropathy?
4. What component in the adjuvant is the source of the problem?

Jump to this post

@dont Don, we need really educated people like you to do the intense research that is needed to study Neuropathy and the Shingles Vaccine. I did hear from someone some years ago about developing Neuropathy after being vaccinated for Shingles. Please do keep us informed of your discoveries. I see a Class Action Suit in the making. I really do, not that it will help you to feel well, but perhaps, justice will be served. Please keep us all informed of your discoveries. Lori Renee

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@lorirenee1

@dont Don, we need really educated people like you to do the intense research that is needed to study Neuropathy and the Shingles Vaccine. I did hear from someone some years ago about developing Neuropathy after being vaccinated for Shingles. Please do keep us informed of your discoveries. I see a Class Action Suit in the making. I really do, not that it will help you to feel well, but perhaps, justice will be served. Please keep us all informed of your discoveries. Lori Renee

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My current thoughts are that the incidence of people who develop SFN from Shingrix is very low compared to the incidence of getting shingles with postherpetic neuralgia that even if it is listed as a potential side effect, it would be best to receive the vaccine. Of course, it would be ideal to identify the "allergen" in the vaccine and screen people for it BEFORE vaccination.

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