Seroquel tapering & withdrawal - Recommendations please!

Posted by mick656 @mick656, Dec 2, 2025

I'm currently on venlafaxine and mirtazapine and about 3 months ago I missed a venlafaxine dose by accident and I paid dearly for it with the withdrawal, I was given seroquel 25mg twice a day, to take the edge off, over a few weeks I ended up at 75mg twice daily and felt I didn't have any effect on me so my doctor and I decided I'd come off it ,I tapered down to 25mg twice daily and within 3 days I notice intrusive thoughts coming in waves with tension headaches, so by day 4/5 I went back to 50mg twice daily to try slow the taper but the damage was done I went into a withdrawal state of anxiety intrusive thoughts and no sleep so had to go back to doctor today just to explain how everything happened and he decided to increase it back to 75mg twice daily again, has anyone had anything similar happen

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How to taper off of 25 mg of Seroquel after 4 weeks.

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Hello @tabby61 and @myself44,

I combined your discussions on tapering off of seroquel into the discussion titled:

"Seroquel tapering & withdrawal - Recommendations please!"
- https://connect.mayoclinic.org/discussion/seroquel-withdrawal-need-some-reassurance-please/

Here you can meet one-another and other members discussing how to properly taper off of seroquel and the experiences members have had doing so.

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