Rifampin: Tooth Enamel?

Posted by kayskid @kayskid, Jun 13, 2020

I started EMB, AZ, RIF five weeks ago. Began to notice tooth discoloring after two weeks. Literature says RIF and cause this. I am afraid to visit dentist due to COVID. How common is this? Is there tx?

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@sueinmn

I was on Rifampin for 18 months, and found twice daily, thorough use of my electric toothbrush with an extra soft head kept the discoloration away. I didn't realize it was making such a difference until we went on a two week trip and I just took a regular brush to save space - by the time we got home, I had staining and it took 2 weeks of 3x/day brushing to dislodge it. I use it on on gums and tongue as well as teeth. My dentist has some infectious disease training, and explained that in addition to the staining properties of Rifampin, one of my other meds was causing "stickier" than normal plaque, which made things worse. Perhaps this is the difference in whether patients see staining from Rifampin or they don't?
Sue

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Hi Sue, I’m getting ready to start this med due to latent TB, is there anything I should be worried about?

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@rocky629

Hi Sue, I’m getting ready to start this med due to latent TB, is there anything I should be worried about?

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Rifampin or rifabutin can cause tooth staining or orange urine.
Here is a list of the side effects to be alert for.
https://medlineplus.gov/druginfo/meds/a682403.html
I took mine in combination with 2 other drugs for over 18 months, and did not have serious side effects, but my teeth seemed more inclined to sticky plaque, so I Khadr them cleaned every 3-4 months.
Sue

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I have been on rifampin for about 2 months, I am rinsing with 1 part hydrogen peroxide and 1 part water daily. I also gargle with salt water. I am going to have my teeth cleaned every 4 months. I have not seen staining yet but will be monitoring to see if I need to get them cleaned every 3 months.

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@sueinmn

Rifampin or rifabutin can cause tooth staining or orange urine.
Here is a list of the side effects to be alert for.
https://medlineplus.gov/druginfo/meds/a682403.html
I took mine in combination with 2 other drugs for over 18 months, and did not have serious side effects, but my teeth seemed more inclined to sticky plaque, so I Khadr them cleaned every 3-4 months.
Sue

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Thank you so much for the info 🙏🏼

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@sherrig

I have been on rifampin for about 2 months, I am rinsing with 1 part hydrogen peroxide and 1 part water daily. I also gargle with salt water. I am going to have my teeth cleaned every 4 months. I have not seen staining yet but will be monitoring to see if I need to get them cleaned every 3 months.

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Thank you…. I’ve been a hot mess and I’m afraid to start rifampin. I guess it’s basically staying on top of my gums and teeth. 🙏🏼

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