R-Lipoic Acid for neuropathy

@dmcatoe I take na-R-ALA 1200 mg daily along with some other supplements to hopefully slow or possibly stop the progression of my neuropathy (my pros). My cons are the cost but I wasted money on much worse things. There is another discussion on the topic in case you haven't seen it.
-- Does any neurologist prescribe Alpha Lipoic Acid?: https://connect.mayoclinic.org/discussion/does-any-neurologist-prescribe-alpha-lipoic-acid/

Here's a search of Connect listing related discussions and comments from members who have posted about R-Lipoic Acid - https://connect.mayoclinic.org/search/.

I don't have pain with my neuropathy, only the numbness and some tingling but if you have pain and it helps that might be another pro. Here's some research:
-- Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications: https://link.springer.com/article/10.1007/s10787-026-02159-9

If you want to dig a little deeper into more research, Google Scholar has a lot of research on the supplement - https://scholar.google.com/scholar

I have used Alpha Lipoic Acid for sometime now. At first it worked and I didn't have the terrible pain, but now it doesn't seem to be very helpful. I tried to stop taking it, but I had peripheral neuropathy every night. I am back to taking it again.

I've been taking it for a couple of years and it seems to take the edge off of the pain.

I take 900 mg a day of R Alpha Lipoic Acid (R ALA). That is 300 mg three times daily. As a result, I have been able to reduce gabapentin dosage in half, from 2400 mg daily to 1200 mg. My mild diabetic neuropathy is now pretty well controlled. I drink at least 8 oz of water with each R ALA capsule to avoid slight upset stomach.

I have been taking R-ALA now for several years. It has minimally helped me. I now take 300mg twice a day and am using some that come with coconut oil. I have noticed an improvement in my PN and even a little in the pain I have in my right foot toe caused by a degenerative disc. Nothing earth shattering but it has taken the edge off.

I was diagnosed with peripheral neuropathy a year ago. I read about Alpha Lipolic Acid as one of the best supplements for neuropathy. I checked about its side effects and I believe it is very safe.
I am taking two 600 mg pills daily. I am not feeling better but my symptoms have not worsen in more than a year.

I do appreciate your comments because it is true, most vitamins from the B group are good for neuropathy. I am having and injection of B12 every two weeks, vitamin B1, and I have vitamin B6 which is also good, but can also be bad for neuropathy. Today I ordered a blood work to see how it is.
I was told by the neurologist, after the EMG test, that the myelin in my tibial and peronial nerves were damaged beyond repair.
I am feeling much better with the treatment I am following.

@amota try adding HEME iron. I to do the B12 and all the rest and adding the HEME iron did the trick for me. My nerves are damaged beyond repair and I don’t know why the doctors don’t suggest the iron because the research is there. You just have to be aware that your ferritin levels top off with the heme iron so you can’t take too much or it’s toxic but every time my ankles and feet start acting up. I take the HEME iron.