Pvc’s

I can't speak very knowledgeably about PVCs because it's not one of my issues. Mine was AF. AF can cause damage to the heart, and other disorders and diseases can cause AF. Chicken and egg conundrum.
An example is hypertension. If blood pressure is too high, and it's not a condition of the heart that is causing it (meaning it's almost certainly kidney function that is the problem), the heart's left ventricle will begin to thicken in the walls to mee the increased demand to keep blood flowing in the volume you need to keep your organs in good condition, and your brain as well. If the walls thicken, it can lead to mitral valve prolapse or to collagen deposition around the mitral valve, which begins to compromise it. If the mitral valve prolapses or begins to degrade, it can cause AF. Or, AF can cause structural changes in the myocardium and lead to mitral valve problems. Either or...
PVCs and PACs are normal for most people........IF......they happen irregularly and seldom. Every heart has some of both, but we're typically talking about two, six, ten a day...not continuous runs that last for hours. Those signify a (usually treatable) electrical disorder. Often the best method of stemming their larger numbers, but most especially when their hosts report being miserable and feeling very unwell/anxious, that an electrophysiologist will attempt to ablate the tissue causing the premature beats. Or, if that isn't an option, or it fails after two/three attempts at ablation, they'll suggest a pacemaker. That's a whole 'nuther topic.