Prograf versus Adoport

Posted by wildcat @wildcat, Mon, Sep 30 6:22am

Hello from Scotland everyone!

I have been on Prograf, without any major problems, since my liver transplant five years ago. My hospital, The Royal Infirmary of Edinburgh, has decided to move all patients from Prograf to Adoport. They have been honest in telling us that the cost benefits are significant for our national Health Service.

I wonder if any of our members have any thoughts/comments/ information on the differences between these two drugs?

Of course, I trust my hospital to make wise choices on my behalf but I am also anxious about changing from a drug which has served me very well since my transplant.

Good Morning from Georgia in the USA,
I just passed my two year mark post liver transplant at the Mayo Clinic in Jacksonville. I did a quick search and found an article covering a study doing an actual comparison between the two. The study can be found at "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094386/". Results showed no overall issues. Good luck with everything.
Best regards

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@wildcat I just googled adoport. Prograf and adoport both have tacrolimus as their active ingredient, adoport is basically just a generic. A six month comparison of them on renal transplant patients yielded these results:
Results
A total of 48 patients received Prograf® and 51 received Adoport®. At 6 months, no statistically significant differences were identified in the rates of patient survival, graft survival, acute allograft rejection, delayed graft function, calcineurin inhibitor toxicity or cytomegalovirus infection occurring within the two groups.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094386/
That of course is not liver transplant patients but I would expect the results to be the same since prograf and adoport are both tacrolimus.
JK

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Thank you so much for your prompt reply. It is good to know that your findings echo mine. The few studies I have found here say there are no major differences.

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Thank you so much. Yes, I expect that renal cases would be similar to liver transplant but it is very reassuring to hear from you all. Thank you also for taking the time to send such a detailed reply.

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@wildcat

Thank you so much. Yes, I expect that renal cases would be similar to liver transplant but it is very reassuring to hear from you all. Thank you also for taking the time to send such a detailed reply.

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@wildcat I am also post liver transplant. I was on tacrolimus for a while but it was causing my creatinine to be high so I was switched to sirolimus. That has also worked well for me. I was three years post last week. I live in NH, the transplant was done at Mass General Hospital in Boston.
JK

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@wildcat I am 9 months post transplant and I'm on 1mg prograf every 12 hours. My doctors insisted on the brand name prograf for some reason. I'm going to ask them about this on my next follow up.

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I have both a liver and a kidney transplant. My own experience is that my kidney requires that I am on a highter dose of tacrolimus than if I hade only a liver transplant. Both kidney and liver teams have agreed on my therapeutic dosage.
@wildcat, One of my antirejection drugs after my transplant was Prograf. Then I was switched to the generic tacrolimus. My doctors alerted me that they would keep an eye on it to be certain that it worked for me. I did / and still do have good results with the generic brand.

When will you begin the new medication?

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@rosemarya

I have both a liver and a kidney transplant. My own experience is that my kidney requires that I am on a highter dose of tacrolimus than if I hade only a liver transplant. Both kidney and liver teams have agreed on my therapeutic dosage.
@wildcat, One of my antirejection drugs after my transplant was Prograf. Then I was switched to the generic tacrolimus. My doctors alerted me that they would keep an eye on it to be certain that it worked for me. I did / and still do have good results with the generic brand.

When will you begin the new medication?

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@rosemarya @wildcat One thing my transplant doctor saiy, was that generics were fine, but to stay with the same generic. So my pharmacy knows that I want one made by a specific pharmaceutical company and complies with that.
JK

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@contentandwell

@wildcat I am also post liver transplant. I was on tacrolimus for a while but it was causing my creatinine to be high so I was switched to sirolimus. That has also worked well for me. I was three years post last week. I live in NH, the transplant was done at Mass General Hospital in Boston.
JK

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I have always been on tacrolimus and it has worked well for me but I know others who have switched to cyclosporin. Now that I understand that Adoport is the generic tacrolimus I am more reassured that it should be okay. Thank you for your response.

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@gaylea1

@wildcat I am 9 months post transplant and I'm on 1mg prograf every 12 hours. My doctors insisted on the brand name prograf for some reason. I'm going to ask them about this on my next follow up.

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My doctors also insisted that I use Prograf and no other brands. It was explained to me that there could be minor differences in brands which would require close monitoring and so it was safer to stick to one brand only. My doctors here have assured us that the changeover will be closely monitored with additional blood tests etc. Thank you for your response.

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@rosemarya

I have both a liver and a kidney transplant. My own experience is that my kidney requires that I am on a highter dose of tacrolimus than if I hade only a liver transplant. Both kidney and liver teams have agreed on my therapeutic dosage.
@wildcat, One of my antirejection drugs after my transplant was Prograf. Then I was switched to the generic tacrolimus. My doctors alerted me that they would keep an eye on it to be certain that it worked for me. I did / and still do have good results with the generic brand.

When will you begin the new medication?

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Thank you for your response. It is really good to know that Adoport seems to work just as well as Prograf.

I will change to Adoport when I have used up my existing stock of Prograf and I'll be closely monitored with additional blood tests etc

Can I take this time to thank all of you who have taken the time to respond to me today. Your positive responses mean I have no concerns about the change at all.

This is what Mayo Connect is all about and it is wonderful to have links to you all.

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@rogerhorton

Good Morning from Georgia in the USA,
I just passed my two year mark post liver transplant at the Mayo Clinic in Jacksonville. I did a quick search and found an article covering a study doing an actual comparison between the two. The study can be found at "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094386/". Results showed no overall issues. Good luck with everything.
Best regards

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Congrats on your 2-year transplant-versary @rogerhorton. I see that you joined Connect around the time you were waiting or getting your transplant. So nice that your first post was to help a fellow liver transplant recipient. It's always a curious interest to me when, why and what topic entices members to make their first post.

How are you doing? What does post-transplant life look like for you?

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@contentandwell

@rosemarya @wildcat One thing my transplant doctor saiy, was that generics were fine, but to stay with the same generic. So my pharmacy knows that I want one made by a specific pharmaceutical company and complies with that.
JK

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I order my immunosuppressants from Mayo, Rochester. The prices are close to the prices of my online ins pharmacy. I can get them in 2 days and they are generics as prescribed….tacrolimus, mycophenolate mofetil, and prednizone. My other meds, I order from my online insurance pharmacy, which can take longer.

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@cmael

I order my immunosuppressants from Mayo, Rochester. The prices are close to the prices of my online ins pharmacy. I can get them in 2 days and they are generics as prescribed….tacrolimus, mycophenolate mofetil, and prednizone. My other meds, I order from my online insurance pharmacy, which can take longer.

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@cmael. I get mine from a CVS Specialty pharmacy in Boston. It works out well because they need a signature at delivery so I have them delivered to the CVS in our town so I don’t have to wait at home for them.
JK

Liked by cmael

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@colleenyoung

Congrats on your 2-year transplant-versary @rogerhorton. I see that you joined Connect around the time you were waiting or getting your transplant. So nice that your first post was to help a fellow liver transplant recipient. It's always a curious interest to me when, why and what topic entices members to make their first post.

How are you doing? What does post-transplant life look like for you?

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Hi Colleen, All is going great with my post transplant life, thank you for asking. I was very active before the transplant and have continued at the same pace. I ran a half-marathon 14 months after transplant and completed a full marathon at the 18 month mark. I am currently training for another half-marathon in early January.
I have met my donor's family and we have a very close relationship. We only live about 90 minutes apart so we are able to visit on a regular basis. I was at Mayo-Jax last week for my two year follow up and everything is perfect. The only med. i am on is the Tacrolimus 2mg twice a day. Bloodwork is every two months and my next check up is in a year.
I am very appreciative of everyone at Mayo and enjoy seeing them when i make my visits.

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