I have both a liver and a kidney transplant. My own experience is that my kidney requires that I am on a highter dose of tacrolimus than if I hade only a liver transplant. Both kidney and liver teams have agreed on my therapeutic dosage. @wildcat, One of my antirejection drugs after my transplant was Prograf. Then I was switched to the generic tacrolimus. My doctors alerted me that they would keep an eye on it to be certain that it worked for me. I did / and still do have good results with the generic brand.