I live with someone that takes this medication and he is like Jekyll and Hyde sometimes. People have told me that this medication can make people act like that. Anyone else have experience taking prednisone long term? I don't know if I can handle living with him for the rest of my life. He gets verbally abusive when he gets angry and he can blow a fuse at any time. There is no way to know when he is going to get ticked off about something. He is very difficult to live with and the abuse has taken its toll on me.