Is your blood sugar elevated as well? Prednisone can raise blood sugar, which in turn can raise triglcerides, which can raise total cholesterol. I would check with your primary care physician and have them compare current lipid profile and blood sugar with one taken before you started prednisone. I worked as a dietitian for 30 years before retirement and knew some things to try, but needed more info than total cholesterol.

A blood sugar was not part of the exam. I have asked if it were possible to check that. My ratio has always been good, but this result doesn’t include that…I don’t understand why. Thanks for your help.

Was it a fasting sample? Looks like all the change was in triglycerides and VLDL (which are high in triglcerides). Looks like your HDL is great and your LDL hasn’t changed. Prednisone can raise blood sugar.

I believe prednisone has caused my blood sugar to rise to tipping over into pre diabetic level. Can't be sure of course but seems too much of a coincidence to be otherwise.

No the sample was taken in the afternoon

I’d ask your primary physician if you could get a fasting blood sugar and fasting lipid profile. Triglyceride and blood sugar levels change all day long.

@jth4d, I agree with @virginiaj. My Mayo primary care doctor always does my annual labs with a fasting blood sugar and fasting lipid profile. I have to limit the types of food I eat for my previous evening meal and eat nothing after 7 pm. They usually schedule my fasting labs first thing in the morning so I can eat afterwards. Here's some information I found that may be helpful.

Cholesterol test: https://www.mayoclinic.org/tests-procedures/cholesterol-test/about/pac-20384601
Eating to Lower Triglycerides (PDF): https://www.uwhealth.org/healthfacts/nutrition/361.pdf

I stopped drinking all alcohol due to other health problems and it is one of the things that can raise triglycerides and sugar levels.