I had been culturing negative for over a year and doctor decided to take me off the drugs the other day. However four weeks later, I found out that my last culture (taken at the last visit when doctor took me off drugs) came back positive. Did another culture a few days ago and am awaiting those results. Dr. said that I could stay off meds but I decided to remain on azithromycin and clofazimine in the meantime. If subsequent culture is positive, he wants me to start the inhaled arikayce. Has anyone else experienced being negative for over a year and then culturing positive at the very end when you were to stop the meds? If so, did you go back on drugs almost immediately or simply monitor for a while?