ONIVYDE irinotecan liposome
Has anyone here been treated with Onivyde? After 10 treatments with gemcitibine/abraxane/cisplaten and 8 treatments with gemcitibine/abraxane, my wife's CA19-9 is still climbing and a lung nodule has grown 30% in 6 weeks since the last CT.
Today the oncologist presented 2 options. Switch to Onavyde + 5fu, OR, some yet unidentified clinical trial.
The Onivyde is supposed to be a reformulated irinotican which is more well tolerated. My wife's pre-surgery regimen was folfirinox (9 treatments) which included the old irinotican + 5fu + oxalyplaten. It worked well dropping the CA19-9 below 35 and making the tumor operable.
We've been asking the oncologist about switching back to folfirinox because the gemcitibine/abraxane has not worked and this Onivyde + f5u might be a good option.
She has also just started the screening process for a clinical trial but it will be awhile before we know the details and whether they accept her. The clinical trials have appeal because they are targeted therapies based on specifiecally identified tumor mutations rather than the nuclear approach of the tradioinal chemos.
Any comments on the Onivyde?