What is the difference between Octreotide and Lanreotide?

He will receive monthly octreotide shots as that seems to be UCSF preference. I was confused as I thought the lanreotide could be self administered (which was only reason we were interested in that one) but self-administered only true for short acting shot.

@carrie567, has your husband started treatment? How is he doing?

I just had my #40 Lanreotide. Pancreatic NET with liver mets. Distal pancreatectomy, splenectomy, cholecystectomy, partial stomach resection and debulking liver mets.

@colleenyoung Yes has had first shot and no side effects from it. Thanks

Hi, I have been on Octreotide for 4 years but my oncologist might prescribe me Lanreotide. I had my fourth operation on 11/10/2025 where the doctors had to remove my terminal ileum because of the obstruction caused by adhesions, which has led to an increase in my diarrhea.
Do you think changing the injection would help with my diarrhea?
I would really appreciate it if you could share your experiences.
Yasemin

This is a good question and one worth asking and finding the right decision for each person.
Here is a link to the discussion which addresses your question:
https://connect.mayoclinic.org/discussion/octreotide-or-lanreotide/
Your NET specialist is probably aware of the NIH (National Institute of Health) study which compares and contrasts Octreatide and Lanreotide. https://pmc.ncbi.nlm.nih.gov/articles/PMC12120025/

After discussing with my NET oncologist I chose the Lanreotide shot. It came down to the NET specialist opinion and my willingness to find out which works better with less side effects for me.
I know that adding Creon to whichever shot, helped with the diarrhea for me, so a discussion with the NET specialist was the best idea. My local Doctor had only given out Ochtreatide but gave me Lanreotide after discussion which has worked out.. I was told that if it did not work, we could try the other..
Wishing you peace of mind and a doable shot with whatever you come to take.

For me Lanreotide didn't work in relieving my Carcinoid Syndrome, Ocreotide did..

Hi Yasemin. Since your diarrhea became significantly worse after your terminal ileum was removed, I would ask your doctor specifically about bile-acid malabsorption before assuming that changing from octreotide to lanreotide will solve the problem.

@vinnie694

Interesting? Have you had any side effects from both?

@diane888 Mostly a little fatigue for a day or 2..