Side effects with omeprazole/Prilosec use

Posted by blueorca @blueorca, May 5, 2018

i am an 18-year user of daily OTC Prilosec. It does a perfect job of controlling my GERD but I am constantly battling side effects of nutritional deficiencies in iron, B-12, magnesium, etc. For example, my hair is extremely thin and loss of energy is a constant problem. I am looking for specific help in knowing which supplements to take for this and in what doses and formats and on what schedule. All the nutritionists I've found locally are not well-versed in Prilosec use. Is there a medical provider out there who specializes in this? And would they be willing to work with me long distance?

Interested in more discussions like this? Go to the Digestive Health Support Group.

Profile picture for graceandpeace @graceandpeace

@kozlo52 and @tigreyes2004, I apologize for jumping into the middle of this thread and maybe this question has already been addressed, but in regards to your friend being on gabapentin, that seems like a massive dosage she's taking - how long has she been taking it, and has she told either her prescribing Dr or another one of her Drs about the memory loss, and if so, what did they say? I'm definitely interested bc I have been on Gabapentin for a year now, but only 300 mg, twice a day, and 100-200 mg once a day (so that's 700-800 mg total each day). I take it for many diagnoses, including pelvic floor dysfunction, IBS-C&D, Interstitial cystitis, and fibromyalgia, as a nerve relaxer to help with chronic pain that stems from all of those. I have also been on other meds like Cyclobenzaprine 5 mg (flexoril) (muscle relaxer) daily, and Oxybutinin 5 mg as needed for bladder spasms from the Interstitial cystitis. So, I was also wondering if your friend is taking any other meds that could either be the culprit of her memory loss, or ganging up with the gabapentin to cause her memory loss. I just turned 45, but have always had memory problems; my Dr says it's probably caused by stress; however, I definitely (as well as my family) have also noticed my memory getting worse since being on these various meds, so I was just curious to find out more about your friend, and if she has found anything out about her memory loss. As far as the weight gain goes while taking Gabapentin, I've actually lost weight since being on it. Because of my IBS and IC, I've had to be on the Low FODMAP diet as well as an IC diet (low to no acid diet), and so thankfully, the gabapentin hasn't gotten me there! I went from weighing 123 (I'm only 4'8"), to weighing 92 lbs. My Dr actually has me trying to gain now, so I believe at my last appointment I had gained a whopping 3 pounds, ha! Anyway, thank you for any more information that you can give me.

Jump to this post

I only took Gabapentin for a couple of weeks & I was getting forgetful but I just thought it was from stress but I got off of it. I tapered off. I just felt confused & I was on 2 a day 200 mg.

REPLY
Profile picture for tigreyes2004 @tigreyes2004

I only took Gabapentin for a couple of weeks & I was getting forgetful but I just thought it was from stress but I got off of it. I tapered off. I just felt confused & I was on 2 a day 200 mg.

Jump to this post

Thank you @tigreyes2004 !

REPLY
Profile picture for Kanaaz Pereira, Connect Moderator @kanaazpereira

Hi @nightngale1998,

I found this interesting article about discontinuing PPIs, that you may wish to read: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995199/

I'd really like to invite @kozlo52 @peck1944 @darlia @fourof5zs to this discussion, as they've shared some valuable insights about hiatal hernia and GERD in other discussions.

Jump to this post

@kanaazpereira I realize this is a very late response, but for anyone currently reading through this message board, it should be said that the article the moderator posted is a Q&A with a physician who is a speaker for AstraZeneca, the distributors of the leading PPI, Priolsec. I found his comments re: "rebound acid" to be completely downplayed and neglectful in mentioning any of the studies that reveal strong evidence that this is, in fact, a "significant clinical issue" for patient's experiencing it.

@kanaazpereira: you should be completely transparent in the information that you are posting, particularly as moderator of this forum.

REPLY
Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

Jump to this post

@kanaazpereira: a doctor unaffiliated with any Pharma companies and the founding editor of NEJM's Journal Watch - Gastroenterology, wrote a piece called "Why Are PPIs Used in the First Place" over at NEJM. I'm unable to post links as I'm not a moderator.

The New England Journal of Medicine has long been one of the most respected journals in the world. Please, do your research.

REPLY
Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

Jump to this post

Hello @eleanorm,
Thank you for calling attention to the physician-pharma association in the article I had cited in a previous post – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995199/ – but first, I’d like to extend a warm welcome to you and sincerely look forward to getting to know you better, as and when you are able to share more about yourself.

You are absolutely correct in saying, “...you should be completely transparent in the information that you are posting, particularly as moderator of this forum.”
As a moderator, I want to communicate in a clear and professional way each time I put something in public view – it is a reflection of myself, of the community, and of course, my employer. But, I would be remiss not to mention a few observations:

1) When manuscripts are accepted, disclosures of conflict of interest, relevant financial interests, activities, relationships, and affiliations, for each of the authors are published in the Acknowledgment section of the article, or the Biography section of the article...and thereby disclosed to readers.
**With regard to the author of the article in question – Dr. Pandolfino (Chief of Gastroenterology and Hepatology, Professor of Medicine, Northwestern University) – the exact disclosure(s) is clearly stated under “Footnotes” in the Biography section of the article.
**I thought – and am still of the opinion – that the inclusion of such statement/footnote suffices for transparency. However, if I were citing an article authored/published by Mayo Clinic, I would be certain to specifically mention any external association in my post.

2) PubMed Central® (PMC – the ‘resource' for the article) is an archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM). The presence of an article does not reflect an endorsement of, or concurrence with, the contents of the article.
https://www.ncbi.nlm.nih.gov/pmc/about/disclaimer/
**Gastroenterology and Hepatology journal publishes peer-reviewed original papers, metaanalyses, systematic reviews, and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. It is one of several reliable and authoritative resources for GI-related interest groups – on par with the New England Journal of Medicine (NEJM), which includes variety of medical-interest groups.
https://www.gastroenterologyandhepatology.net/about/
3) As you correctly stated, M. Brian Fennerty, M.D. is "a doctor unaffiliated with any Pharma companies and the founding editor of NEJM's Journal Watch.” But might I request you to keep in mind that this standard applies solely to the ‘editors’; and not to ‘authors’.
"No NEJM editor is permitted to have any financial relationship with any biomedical company.” https://www.nejm.org/media-center/integrity-safeguards
**Here again, I thought you might wish to read about Dr. Fennerty’s disclosures and association with pharmaceutical companies, prior to his role as editor:

https://www.medscape.org/viewarticle/457393_3M Brian Fennerty, MD
M. Brian Fennerty, MD, Professor, Section Chief of Gastroenterology, Oregon Health Sciences University
Disclosure: Consultant/Speakers Bureau: AstraZeneca, TAP, Wyeth;
Research Grants: AstraZeneca, Eisai Inc, Janssen Pharmaceutica

https://projects.propublica.org/d4d-archive/search?utf8=✓&term=M.+Brian+Fennerty%2C+MD&state%5Bid%5D=&company%5Bid%5D=&period%5B%5D=&services%5B%5D=

@eleanorm, our community members should feel safe, which is why we monitor the conversations AND rely on community members like yourself to report if you felt anything was amiss – I hope this (very long) explanation is helpful.
You can also read more about why and how we moderate on Connect: https://connect.mayoclinic.org/about-our-moderators-and-mentors/ Please don’t hesitate to connect with me:) with any further questions or concerns; I do look forward to hearing from you.

REPLY

Ok, I went to my gastro and having symptoms of nausea that got better with an antacid. So, Im put on 40mg omeprazole a day since Nov. 9th. I had an upper scope and nothing was found, no ulcer, inflammation, notta. Im still having stomach troubles, could this medicine be making things worse? Should I even be on this higher amount? I know no one can tell me what to do, just asking around for some insight.
My symptoms are, lack of appetite, on and off diarrhea, gas, cramping, severe fatigue, low grade fever on and off. And nausea if off the medicine. Been going on for at least a few months.
I have chronic constipation from slow transit disorder, so struggling with that.

I just dont want to be taking this medicine if its exacerbating my symptoms.

REPLY
Profile picture for januaryjane @januaryjane

Ok, I went to my gastro and having symptoms of nausea that got better with an antacid. So, Im put on 40mg omeprazole a day since Nov. 9th. I had an upper scope and nothing was found, no ulcer, inflammation, notta. Im still having stomach troubles, could this medicine be making things worse? Should I even be on this higher amount? I know no one can tell me what to do, just asking around for some insight.
My symptoms are, lack of appetite, on and off diarrhea, gas, cramping, severe fatigue, low grade fever on and off. And nausea if off the medicine. Been going on for at least a few months.
I have chronic constipation from slow transit disorder, so struggling with that.

I just dont want to be taking this medicine if its exacerbating my symptoms.

Jump to this post

@januaryjane - Welcome to Mayo Clinic Connect!
It sounds as if you feel worse now than when you started on omeprazole, right? The medication seems to help you with the nausea- decreases acid production in stomach. Your new symptoms with fatigue, low grade fevers, gas and diarrhea sounds more like an intestinal infection of some kind. It might be a good idea to contact your doctor again. You may need some more tests to see why you are so much worse. What do you think? Many of us here recognize your symptoms and know how you feel - I do! Can you please get back to us about what the doctor thinks?

REPLY
Profile picture for januaryjane @januaryjane

Ok, I went to my gastro and having symptoms of nausea that got better with an antacid. So, Im put on 40mg omeprazole a day since Nov. 9th. I had an upper scope and nothing was found, no ulcer, inflammation, notta. Im still having stomach troubles, could this medicine be making things worse? Should I even be on this higher amount? I know no one can tell me what to do, just asking around for some insight.
My symptoms are, lack of appetite, on and off diarrhea, gas, cramping, severe fatigue, low grade fever on and off. And nausea if off the medicine. Been going on for at least a few months.
I have chronic constipation from slow transit disorder, so struggling with that.

I just dont want to be taking this medicine if its exacerbating my symptoms.

Jump to this post

I see her on the 10th. Well i was having some of those symptoms before. But the cramping and gurgling are a little worse. I started taking some probiotics which I think have helped. But I never have had all this together. Something is up, just not sure what. I leave next weekend for vacation.

REPLY
Profile picture for januaryjane @januaryjane

Ok, I went to my gastro and having symptoms of nausea that got better with an antacid. So, Im put on 40mg omeprazole a day since Nov. 9th. I had an upper scope and nothing was found, no ulcer, inflammation, notta. Im still having stomach troubles, could this medicine be making things worse? Should I even be on this higher amount? I know no one can tell me what to do, just asking around for some insight.
My symptoms are, lack of appetite, on and off diarrhea, gas, cramping, severe fatigue, low grade fever on and off. And nausea if off the medicine. Been going on for at least a few months.
I have chronic constipation from slow transit disorder, so struggling with that.

I just dont want to be taking this medicine if its exacerbating my symptoms.

Jump to this post

What kind of foods are you eating? Try a low acid diet, no soda, booze, only low acid coffee, no tomato products, Italian, mexican, fried foods. Drink water, almond milk, no fruit juices. Eat more fiber and see if that helps.

REPLY
Profile picture for riflemanz64 @riflemanz64

What kind of foods are you eating? Try a low acid diet, no soda, booze, only low acid coffee, no tomato products, Italian, mexican, fried foods. Drink water, almond milk, no fruit juices. Eat more fiber and see if that helps.

Jump to this post

Thank you that’s exactly what I’m doing for years already.

REPLY
Please sign in or register to post a reply.