Pembrolizumab (Keytruda), Cannabis and Cannabinoids

Posted by lighthouse68 @lighthouse68, Aug 12, 2018

Is it advisable to use CBD and/or THC Oil to try and shrink my tumors. I have stage 4, metastatic, non-small lung cancer. I read on study that suggests it cuts in half the efficacy of the Keytruda. Any thoughts?

Hi Everyone,

MY dad has stage 3B lung cancer and he went through chemo radio , surgery but it came back then he was on Keytruda and Chemo we had %70 success in the mid of treatment but then suddenly he got infection and couldnt keep going on treatment for 6 weeks then he completed but scan result came out the size of tumor actually increased compare to previous one. then he was on another chemo and after that was completed the test result was stable and now he is on Opdivo he just took the first one and I also provided him thc oil but some research says its not good to give both at same time. I do know what to do? anyone used both at same time?

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@robin47

Hi Everyone,

MY dad has stage 3B lung cancer and he went through chemo radio , surgery but it came back then he was on Keytruda and Chemo we had %70 success in the mid of treatment but then suddenly he got infection and couldnt keep going on treatment for 6 weeks then he completed but scan result came out the size of tumor actually increased compare to previous one. then he was on another chemo and after that was completed the test result was stable and now he is on Opdivo he just took the first one and I also provided him thc oil but some research says its not good to give both at same time. I do know what to do? anyone used both at same time?

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I am stage 4 mesothelioma. I am using Keytruda and THC at the same time. I used THC for over 4 months now, and only started the Keytruda treatment last week. My oncologist didn't stop me using the oil. He said current research study is limited and no conclusion to strongly suggest one way or the other.

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@robin47

Hi Everyone,

MY dad has stage 3B lung cancer and he went through chemo radio , surgery but it came back then he was on Keytruda and Chemo we had %70 success in the mid of treatment but then suddenly he got infection and couldnt keep going on treatment for 6 weeks then he completed but scan result came out the size of tumor actually increased compare to previous one. then he was on another chemo and after that was completed the test result was stable and now he is on Opdivo he just took the first one and I also provided him thc oil but some research says its not good to give both at same time. I do know what to do? anyone used both at same time?

Jump to this post

@robin47– Welcome to Mayo Connect. I am not sure why your post was not answered in December. I just received it. I apologize for this oversight.
I'm so sorry that your dad is going through this. It must be very very difficult to feel so helpless. Are you his main caretaker? I am a lung cancer survivor but I never had immunotherapy. What type of lung cancer does he have? Small cell (SCLC) or non-small cell (NSCLC)?
I think that you can google Opdivo and see the side effects and how to avoid some of them, if your dad experiences them.
https://www.opdivo.com/

There is some research that indicates that CBD oil interferes with immunotherapy. And as you know, the use of CBD oil and how it interacts with other drugs is far from giving us definitive answers.
https://www.oncologynurseadvisor.com/general-oncology/cannabis-reduces-immunotherapy-response/article/688059/
https://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/The-effect-of-cannabis-use-on-tumor-response-to-Nivolumab-in-patients-with-advanced-malignancies
https://www.medicaljane.com/2014/08/28/study-cannabinoids-may-increase-lung-cancers-susceptibilty-to-specialized-killer-cells/

The ultimate decision will be up to your dad. Have you asked him about this? What does he want to do? As a cancer survivor of 21 years (NSCLC) I can tell you that unless a cancer patient can not answer questions all decisions should be made by the cancer patient. It is his/her power. I'm sure that you know this.
Please get back to me and let me know if what your dad's decision is. My best, Merry

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I lost my brother to cancer 3 years ago. During his last months, I did quite a bit of research into CBD oil and how it works on cancer. Please correct me if I am incorrect. What I gathered is that cancer cells each have a lifespan. CBD oil retards reproduction of cancer cells. As a result, over time, more cancer cells will die off than new cells being produced. This results in the cancer shrinking and hopefully dying off. Unfortunately my brother and his family could not be convinced to try it because of state laws at that time.

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@binky957

I lost my brother to cancer 3 years ago. During his last months, I did quite a bit of research into CBD oil and how it works on cancer. Please correct me if I am incorrect. What I gathered is that cancer cells each have a lifespan. CBD oil retards reproduction of cancer cells. As a result, over time, more cancer cells will die off than new cells being produced. This results in the cancer shrinking and hopefully dying off. Unfortunately my brother and his family could not be convinced to try it because of state laws at that time.

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@binky957 — Good morning and welcome to Mayo Connect. I am so sorry for the loss of your brother. It must have been very painful to have watched his decline. Unfortunately at this time there is no proof that CBD oil or any cannabis product kills cancer cells. Even if it will prove to be true that these products can kill cans cells people with cancer do not have the luxury of time. Some cancer cells reproduce at a very high rate, that's why some people die so quickly. If cancer cells can be killed off faster by any substance then that's a gold mine! You might find this interesting: https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq#section/_7
I hope that this helps to understand this horrible disease better.

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@ina3

@lighthouse68 Can you please share your experience with Keytruda? Did you do it together with chemo? For how long did you use it? Thanks.

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Please post an update, as I am about to add Keytryda for same condition.

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@lisamb

I was wondering if anyone is on alectinib for stage 4 metastatic non-small cell lung cancer? I have a family member who has been on it since July of this year and has responded very well to this therapy drug.

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@lisamb – is this a chemo or immunotherapy drug?? And what kind of non small cell lung cancer?? I myself have stage IV with high pdl1 protien adenocarcinoma

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@merpreb

@robin47– Welcome to Mayo Connect. I am not sure why your post was not answered in December. I just received it. I apologize for this oversight.
I'm so sorry that your dad is going through this. It must be very very difficult to feel so helpless. Are you his main caretaker? I am a lung cancer survivor but I never had immunotherapy. What type of lung cancer does he have? Small cell (SCLC) or non-small cell (NSCLC)?
I think that you can google Opdivo and see the side effects and how to avoid some of them, if your dad experiences them.
https://www.opdivo.com/

There is some research that indicates that CBD oil interferes with immunotherapy. And as you know, the use of CBD oil and how it interacts with other drugs is far from giving us definitive answers.
https://www.oncologynurseadvisor.com/general-oncology/cannabis-reduces-immunotherapy-response/article/688059/
https://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/The-effect-of-cannabis-use-on-tumor-response-to-Nivolumab-in-patients-with-advanced-malignancies
https://www.medicaljane.com/2014/08/28/study-cannabinoids-may-increase-lung-cancers-susceptibilty-to-specialized-killer-cells/

The ultimate decision will be up to your dad. Have you asked him about this? What does he want to do? As a cancer survivor of 21 years (NSCLC) I can tell you that unless a cancer patient can not answer questions all decisions should be made by the cancer patient. It is his/her power. I'm sure that you know this.
Please get back to me and let me know if what your dad's decision is. My best, Merry

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@robin47 @merpreb I’ve been getting Keytruda for 1 month. I’ve been taking CBD for 4 months, it seems to very slightly help with the neuropathy in my feet, fingers. After checking Merry’s VERY helpful links here I will now stop the CBD. Thank you both!

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My brother has adenocarcinoma nonsmall lung cancer stage IV. Alectinib is a targeted therapy. He has ALK positive gene. He continues to do well and his scans show a lot of improvements.

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