New here with prostate cancer.

This is from our Moderator, Colleen.
There are so many acronyms related to prostate cancer. When newly diagnosed these can be overwhelming and frustrating. As you become more familiar with the diagnosis, consult with the medical team, read reports, BAM! you start throwing around the acronyms like the best of them.

To help newbies, several of you suggested creating a glossary. Let's get it started. Here are the abbreviations most commonly used in the group:

Updated May 7, 2024

ADT = androgen deprivation therapy
AR = Androgen Receptor
ARSI = Androgen Receptor Signalling Inhibitor
AS = active surveillance
AUS = artificial urinary sphincter
BCR = Biochemical Recurrence - elevated PSA after treatment followed by undetectable test
BMD = bone mineral density
BMI = body mass index
BPH = benign prostatic hyperplasia or hypertrophy
BRACHY = brachytherapy
BRFS = Biochemical Recurrence Free Survival
BS = bone scan
BX = biopsy
Ca = cancer
CAT SCAN = computerized axial tomography; same as CT scan
CBC = complete blood count
CEA = carcinoembryonic antigen
CGA = chromogranin A
CHEMO = chemotherapy
CMP = Comprehensive Metabolic Panel
CRPC = Castrate Resistant Prostate Cancer
CSS - Cancer-Specific Survival
CT SCAN = computerized tomography; also known as CAT scan or CT scan
DART = dynamic adaptive radiation therapy
DMFS = Distant Metastasis-Free Survival
DOM = doctor of oncological medicine
DRE = digital rectal examination
Dx = diagnosis
EBRT = external beam radiation therapy
ED = erectile dysfunction
EPE = Extraprostatic extension
FLA = focal laser ablation
GS = Gleason score
Gy = Gray, the unit of absorbed does of radiation
HDR = high dose rate; as in HDR brachytherapy
HIFU = high intensity focused ultrasound
HR = Hazard Ratio
HSPC = Castrate Sensitive Prostate Cancer
IDC + Intraductal carcinoma of the prostate
IGRT = image-guided radiation therapy
IMRT = intensity-modulated radiation therapy
IOTN = Immuno-Oncology Translation Network
LDR = low dose rate; as in LDR brachytherapy
LHRH = luteinizing hormone releasing hormone
M0 = No Distant Metastasis
M1 = Distant Metastasis
mCRPC - metastatic castration resistant prostate cancer
Mets = metastasis; cancer that has spread to other places in the body
mHSPC = Metastatic Castrate Sensitive Prostate Cancer
MO = medical oncologist
mpMRI = Multi-Parametric MRI
MRI = magnetic resonance imaging
Mx = metastasis
N0-N3 = status of cancer in the lymph nodes; subset of staging
NCCN = National Comprehensive Cancer Network
NCI = National Cancer Institute, USA
NED = No Evidence of Disease.
NIH = National Institutes of Health, USA
nmCRPC = nonmetastatic castration resistant prostate cancer
ONCO = oncologist
OS = Overall Survival
PBRT = proton beam radiation therapy
PC = prostate cancer
PCa = prostate cancer
PCP = Primary Care Physician
PET = Positron Emission Tomography
PI-RADS = prostate imaging-recording and data system; used in assessment and evaluation of MRI scans for risk of prostate cancer
PLND = Pelvic Lymph Node Dissection
PNI = Perineural Invasion
PSA = prostate specific antigen
PSADT = PSA Doubling Time, Prostate-specific antigen doubling time
PSMA = prostate specific membrane antigen
PT = Physical Therapist
QOL = quality of life
RALP = robot-assisted laproscopic prostatectomy; similar to LRP but with “robotic” assistance
RARP = robot-assisted radical prostatectomy (same as RALP)
RCT = Randomized Clinical Trial
RO = radiation oncologist
RP = radical prostatectomy
RT = radiation therapy; also: right side
SBRT = stereotactic body radiation therapy
SE = side effects
SRT = Salvage Radiation Treatment
SUV = Standardized uptake value
SVI - seminal vesicle invasion
Sx = symptom
TPUS =Transperineal Ultrasound biopsy
TRT = testosterone replacement therapy
TRUS = transrectal ultrasound
TURP or TUR/P = transurethral resection of the prostate
TX = treatment
US = ultrasound
UTI = urinary track infection
VMAT = Volumetric Modulated Arc Therapy, a form of IMRT
WBC = white blood cell count

If you want to share more details from your biopsy regarding all the Gleason grades of the cores, percent of cores, and PSA history other pathology of the tissue that may have been identified such as cribriform pattern. All of this additional information will help members provide a wealth of useful information to you for your upcoming appointment. At 75 you are typically at the cutoff age for most Surgeons offering surgery.

Thank You!!

Ok I will try to post the biopsy info. Keep in mind I am not a typist so I make mistakes.
They took 12 samples and 10 of them were positive for cancer.
First one says Gleason score 3+4=7 grade group 2. 20 percent of tumor is greater than Gleason pattern 3
Second one Gleason score 3+4=7 grade group 2. 10 percent of tumor greater than Gleason pattern 3. Perineal invasion present.
Third, Gleason score 4+3=7 grade group 3. 65 percent of tumor greater than Gleason pattern 3.
Fourth, Gleason score 3+4=7 grade group 2. 10 percent of tumor greater than Gleason pattern 3.
Fifth, Gleason score 4+3=7 80 percent of tumor greater than Gleason pattern 3. Perineal invasion is identified.
I did not include any of the ones that were low or not concerning.
Hope this helps.
Jim

I also see expansile cribriform, simple cribriform, glomeruloid, fused gland and poorly formed types.

Gleason is highest so core so 4+3.; What percentage is 4? How many cores with cancer? Location (cancer on both sides usually eliminates focal)
How large is the prostate (will be on MRI)? ROs have cutoffs based on size, the lowest I have seen is 80 so it is more severe BPH that gets excluded.
PNI is not a concern; in almost every biopsy.
All treatments can have bad side effects. Worst is ED, incontinence (both more with surgery); proctitis possible with radiation. Best is you are just dry (90%+ of ejaculate is from prostate so hard to avoid if prostate is removed or fried with radiation).

@jimcarr Expansile (large) cribriform is an aggressive feature. Associated with higher rates of metastasis. That and the 80% T4, 65% T4 cores puts the treatment choices as surgery or radiation. If you are in great health it will help greatly with recovery if you chose surgery. Also look at wheel1s post on surgery specifics. He had excellent results. Urologists do surgery and ROs do radiation so should have consult with both since they have a natural bias with what they do.

Sorry my brain is fried so time for bed. I will be back tomorrow.
Thanks, Jim

Think long and hard about the androgen deprivation therapy (ADT), especially if you are a physically active person. It kicks your a**

@acn25 I had 6 months of Orgovyx at age 68 and it was not a big deal. Sure I had some hot flashes, no libido. I went to the gym for 90 minutes 5 days a week and worked hard at cardio and weights, and I walked 18 holes of golf twice a week. I also took a nap every day.

Would I do it again just for fun? Of course not. Would I do it again because it is the standard of care and my best chance of beating f#cking cancer? Absolutely.

Your experience may vary. Mine was a piece of cake.

@jimcarr Look at my profile here, and on this forum ( https://www.inspire.com/groups/zero-prostate-cancer/discussions/ )to see my journey....user name Toolbelt.

Stay Strong Brother, We Got This.