Myfortic vs Cellcept or Mycophenolate? Share your experience

Posted by Alta Net @altabiznet, 2 days ago

Has anyone been switched from mycophenolate to Myfortic? Is it really better tolerated with the same efficacy?

Myfortic and CellCept are both immunosuppressants used to prevent organ rejection, with Myfortic designed to reduce gastrointestinal side effects through delayed-release formulation.
Key Differences
Formulation and Absorption:
CellCept (mycophenolate mofetil) is a prodrug that is rapidly converted in the body to the active metabolite, mycophenolic acid (MPA).

Myfortic (mycophenolic acid) is an enteric-coated formulation of MPA, designed to release the drug in the small intestine, which can lead to more consistent absorption and reduced gastrointestinal side effects.

Gastrointestinal Tolerability:
Myfortic is associated with less diarrhea, nausea, and abdominal discomfort compared to CellCept due to its delayed-release coating.

Patients who experience GI intolerance with CellCept may benefit from switching to Myfortic.
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Becky, Volunteer Mentor | @becsbuddy | 1 day ago

@altabiznet. People seem to ask this question frequently. The only real difference is in the GI tract. I took cellcept for about 2 years and i suddenly developed diarrhea. My doctor instantly changed me to Myfortic. Neither of us knew that I had developed EPI (exocrine pancreatic insufficiency) which caused an almost 2 years adventure with diarrhea and weight loss (due to malnutrition). We finally got things under control. In the process, I fired my GI doctor and got a new one!
I have tolerated the Myfortic with no problem. In fact, I’m off of it now and just take Rituxan twice a year!

Alta Net | @altabiznet | 1 day ago

In reply to @becsbuddy "@altabiznet. People seem to ask this question frequently. The only real difference is in the GI..." + (show)

@becsbuddy
What is your diagnosis?

Some people report extreme fatigue post Rituximab infusions. How do you tolerate Rituxan, and is it working for you?
Thank you for sharing.

Becky, Volunteer Mentor | @becsbuddy | 1 day ago

In reply to @altabiznet "@becsbuddy What is your diagnosis? Some people report extreme fatigue post Rituximab infusions. How do you..." + (show)

@altabiznet My diagnosis is Clippers—chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids-phew! It means that the immune system attacked my brain and left lesions and my brain wouldn’t work where the lesions were. Along with the drugs, I had therapy to help me walk, swallow, etc. I went from a wheelchair to a walker to a cane to walking unaided and now, back to a cane. It’s been a long road and Mayo Clinic Connect has made all the difference for me! Thank you for asking!
I tolerate rituxan quite well. Yes, I’m tired after, but part of that is the whole experience-usually 4-5 hours for me. I’m just so happy to get it that nothing bothers me!

Alta Net | @altabiznet | 23 hours ago

In reply to @becsbuddy "@altabiznet My diagnosis is Clippers—chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids-phew! It means..." + (show)

@becsbuddy

My diagnosis is scleroderma with Raynaud, but I am also developing peripheral neuropathy. My feet are tingling, getting numb, muscle wasting in the legs, getting off-balance. I have also noticed memory problems and brain fog. From walking independently to a cane + wheelchair. This progression happened very fast and it is getting worse. Rituximab + Cellcept are my next treatment choices.

What is your dose and schedule of Rituximab? For how long does the fatigue last post infusions? Any detail regarding your experience with the drug will be helpful. Thanks

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