my psychiatrist prescribed ENLYTE for depression.

For those interested in the contents and ingredients of Enlyte you can find the information from Drugs.com at weblink. Search Enlyte.

If you use "directvaluedispense.com" the actual equivalent to Enlyte is called ENL on the website. The product is still made by JayMac the manufacturer of Enlyte and appears to have the same ingredients and formulation. Cureent cost as 4/3/2019 was 30 days @ $50 and 90 days @ $150 plus shipping. Also for those using a prescription buying through a pharmacy and your insurance won't cover the cost you can use the GoodRx coupon and cost is about $170 for 30 days.

I would suggest googling their website enlyterx.com or embraceHR.com. You do not need a prescription to order Enlyte. You can order directly from the company for $50 plus shipping cost. I had the gen-o-mind test done & I have a mutation called MTHFR. It is not uncommon & there are two specific genes they test. I have the better one, but it is the reason two prescribers recommended I try it. Yes, after a month I feel a lot better. The thing is I added Effexor 37.5 at the same time to my Lamictal 100 mg regiment. Although I had taken Effexor before at a higher dose, my regiment had been changed & I dropped Effexor & increased the Lamictal so that the adding back of a low dose of Effexor was done at the same time I stared the Enlyte. Supposedly, the gene mutation means we do not metabolize folic acid properly (something like that). I was told people without the gene mutation are electing to take it anyway & reported feeling better. So I do not know. You can ask your doctor to do the swab gene test to see if you possibly have one of the two gene mutations. You can check with your doctor, but it seems it would not hurt to try it for a month & then evaluate your personal experience. Good Luck! Carol

Hello, @chloepoole, and welcome to Mayo Clinic Connect.

So, if I understand correctly, you are now taking a low dose of venlafaxine (Effexor), lamotrigine (Lamictal) and also the folate supplement Enlyte. Will you share a little about your diagnosis and how this combination treatment is working for you? Are you noting any side effects?

Thank you for this post --- I am starting my 14 yr old son on EnbraceHR tonight (had to special order to pharmacy ) his Psych doc said Enlyte but the rep says insurance will pay for EnbraceHR and it is the same formula..... I am desperate to get something to work for my son as 3 drugs (SSRI) have done nothing --- he was genetically tested and he carries two mutations for MTHFR .... anymore information on how this is working or has continued to work for your daughter? My son is currently unable to attend school and has no motiviation - hopeless., thank you.

Hello @gordonjackie722 and welcome to Mayo Connect. I am sure that you are concerned about your son and I hope that this new treatment plan works well for him. I would like to invite @kdutcher and @georgette12 to this discussion as they have also mentioned using this product for depression.

If you are comfortable sharing more, how long has your son be dealing with this debilitating depression?

This started the beginning of the 7th grade at the onset of puberty and now he is a freshman (or should be but isn't attending school ) with his IEP they are allowing him to do online but he really wont or cant do that work. He says he feels like nothing will ever help him etc.... I am hopeful this will make a difference. His psychiatrist said from the genomind genetic report it makes sense why the meds he has been on have not worked -- due to his genetic makeup and I assume and his MTHFR gene mutations.

I'm sure you are holding out great hope for this treatment, @gordonjackie722.

Was he a good student prior to the depression? Was he ever involved in clubs (church, boy scouts, etc.) or team sports prior to 7th grade?

He has never liked school so no never a great student but he was able to finish 6th grade without issue …. he did play baseball and basketball prior to 7th grade but gave up all interest in sports that summer - there are lots of family issues so it was hard to know what was causing the depression and anxiety. We have tried counseling - even having counselor come to the home but nothing has made a dent. He had a teacher come to the home to get him through 8th grade and 7th. Yes hopeful that this will make a difference. There is a strong family history of bipolar and anxiety - my 16 year old has very bad anxiety but Zoloft works for her - not fully but much better than before.

Hi my daughters psychiatrist tried her on every med from A to Z and her reactions were all over the place. After years of trying so many medications from a young age this psychiatrist decided to do with DNA testing on her. It turned out that she has a double MTHFR gene mutations. If you look this up it tells you that people with the MTHFR gene mutation do not metabolize folic and b vitamins properly. Therefore leaving them depleted of what is essential for proper brain function. Having this gene mutation also causes people to not metabolize chemicals properly and this leads to your body not responding correctly to some medications. My daughter's dr. Gave her the Enlyte with delta folate and she did very well with it.