Husband has Gleason score 3+4 = 7 (Grade Group 2 Perineural Invasive)?

You definitely need to follow up with your physician(s) to discuss the specifics of the Intraductal carcinoma (IDC-P) found in your husband’s pathology report.

IDC-P is often associated with more aggressive prostate cancer.

Although some Gleason 3+4 can allow for active surveillance, the presence of IDC-P could shift the recommendation toward definitive treatments like surgery (prostatectomy) or radiation.

Here’s a few questions I’d be asking my urologist or oncologist, regarding the IDC-P finding:

• How extensive is the IDC-P, based on the current pathology report?

• Does the IDC-P observed in this report change the risk assessment in my particular diagnosis?

• Can you help me get a 2nd opinion on my biopsy pathology, especially focused on the severity of the IDC-P?

• Can additional tests (e.g., especially the Decipher genomic testing) help to assess the overall aggressiveness of the PCa, for my specific case?

• How does the current IDC-P finding, in my particular case, affect my treatment options or monitoring plans?

I wish you and your husband all the best, as you chart your path forward!

My urologist provided a copy of what is called the “Patient Report”. It goes over the basics.

Here’s the contact info of the person who helped me get a copy of my GRID report:

Michele Abolafia , Manager Customer Experience, michele.abolafia@veracyte.com, 858.322.6129.

That was 18 months ago, so if Michele is not available I’m sure someone else can help you.

You will have to call to speak to Michele (or someone), during normal business hours, since they must send a release form, to your email address, for you to return via electronic signature.

In addition you will have to send a scanned copy of your driver's license.

That said, Michele told me she would be looking for my completed form while I was still speaking with her, which I was able to turn around in ~10 minutes.

I sent my scanned drivers license directly to her email address, along with an email address they specified....privacy is (obviously) a key concern....

Of course (hopefully), the doctor who ordered your original 3 page Decipher Report could also obtain a copy of your GRID report.

However, I would be surprised if your doctor is going to be willing to take the time to review the intricacies of your GRID report with you...again...it's research use only and contains a boatload of data.

The GRID report is a detailed 7 page report and every page has the heading "Research USE Only"...this is important to keep in mind.

Veracyte has been collecting data since 2015 and they now have >200,000 whole transcriptome tumor profiles.

Apparently the latest Decipher GRID (for Research Use Only) database uses a proprietary AI platform to compile and generate a report that is personalized and based on the genomic test results obtained from the cancer cells removed during your biopsy, as compared to all the others in their database.

In a 23 minute video (Dr. Ashley Ross, MD PhD) explains the info supplied in the Decipher GRID report (found here:

I'm still trying to understand what exactly this all may suggest...

In any case, it is undoubtably much more information than most will want to know and I'm sure most doctors will roll their eyes if you ask specific questions about the intricacies of your GRID info...but for us "data nerds" its where all this is heading regarding individualized treatment plans....for better or worse.....

All the best!!!

@handera ,
I just tried to get my grid report and they refused. The woman I spoke to(not Michele) would not give it to me and said that I must go through my physician. She said that the policy has changed since 18 months ago.