My husband has Gleason score 3 + 4 = 7 (Grade Group 2 Perineural Inva?

Thank you for posting your update.

I wondered a couple of things as you considered your options;
was removal ruled out?
what your urologists recommendation was?
was cribriform detected?

I am in the same boat with (3+4), 63, and have pni and cribriform. No health issues. I am weighing treatments and meet with my urology oncologists in mid-August.
Thanks.
Jon

Luckily, we live in Massachusetts. And he is being seen in Boston and one of the best hospitals. I am definitely gonna be getting a second opinion. We are waiting for the doctor phone call, and we’ll take it from there. Thank you so much! And good luck to you as well.

Thank you!

IDC, like so many things associated with prostate cancer, can vary considerably, so I would defer to conversations with your urologist. The main thing with prostate cancer is finding and treating it while it is still localized.

How hard is it to get the GRID report from Veracyte. Hubby’s urologist doesn’t provide copies of the decipher or Artera.ai results. He just wrote an email and said the report came back as intermediate risk. We would love to see the actual results in print. Do you have to get permission or referral from the doctor in order for Veracyte to provide the info?

You definitely need to follow up with your physician(s) to discuss the specifics of the Intraductal carcinoma (IDC-P) found in your husband’s pathology report.

IDC-P is often associated with more aggressive prostate cancer.

Although some Gleason 3+4 can allow for active surveillance, the presence of IDC-P could shift the recommendation toward definitive treatments like surgery (prostatectomy) or radiation.

Here’s a few questions I’d be asking my urologist or oncologist, regarding the IDC-P finding:

• How extensive is the IDC-P, based on the current pathology report?

• Does the IDC-P observed in this report change the risk assessment in my particular diagnosis?

• Can you help me get a 2nd opinion on my biopsy pathology, especially focused on the severity of the IDC-P?

• Can additional tests (e.g., especially the Decipher genomic testing) help to assess the overall aggressiveness of the PCa, for my specific case?

• How does the current IDC-P finding, in my particular case, affect my treatment options or monitoring plans?

I wish you and your husband all the best, as you chart your path forward!

I have the same question about the GRID and even whether I need that given that the Veracyte report the treatment center shared with me seems complete and shows high risk. So I don't know what more the GRID would tell me, if anything?

Jon: I am 66 and was 4+3 with cribriform and PNI. I did Tulsa Pro at Mayo Rochester last July. 1 year out and no sign of cancer. Very easy treatment for me and zero side effects.

My urologist provided a copy of what is called the “Patient Report”. It goes over the basics.

Here’s the contact info of the person who helped me get a copy of my GRID report:

Michele Abolafia , Manager Customer Experience, michele.abolafia@veracyte.com, 858.322.6129.

That was 18 months ago, so if Michele is not available I’m sure someone else can help you.

You will have to call to speak to Michele (or someone), during normal business hours, since they must send a release form, to your email address, for you to return via electronic signature.

In addition you will have to send a scanned copy of your driver's license.

That said, Michele told me she would be looking for my completed form while I was still speaking with her, which I was able to turn around in ~10 minutes.

I sent my scanned drivers license directly to her email address, along with an email address they specified....privacy is (obviously) a key concern....

Of course (hopefully), the doctor who ordered your original 3 page Decipher Report could also obtain a copy of your GRID report.

However, I would be surprised if your doctor is going to be willing to take the time to review the intricacies of your GRID report with you...again...it's research use only and contains a boatload of data.

The GRID report is a detailed 7 page report and every page has the heading "Research USE Only"...this is important to keep in mind.

Veracyte has been collecting data since 2015 and they now have >200,000 whole transcriptome tumor profiles.

Apparently the latest Decipher GRID (for Research Use Only) database uses a proprietary AI platform to compile and generate a report that is personalized and based on the genomic test results obtained from the cancer cells removed during your biopsy, as compared to all the others in their database.

In a 23 minute video (Dr. Ashley Ross, MD PhD) explains the info supplied in the Decipher GRID report (found here:

I'm still trying to understand what exactly this all may suggest...

In any case, it is undoubtably much more information than most will want to know and I'm sure most doctors will roll their eyes if you ask specific questions about the intricacies of your GRID info...but for us "data nerds" its where all this is heading regarding individualized treatment plans....for better or worse.....

All the best!!!

It definitely sounds like you are a case for active surveillance. Did you see the videos that were posted from the doctors that discuss if active surveillance is right?

Have you had an MRI of your prostate? An MRI guided biopsy assures that the spots that showed up as possibly cancerous are the spots that the samples are taken from. They only get one percent of the prostate when they do a biopsy so they can miss a lot.

Would you consider getting an expert to review your biopsy samples?. It might cost $500.