My husband has Gleason score 3 + 4 = 7 (Grade Group 2 Perineural Inva?

I have the same question about the GRID and even whether I need that given that the Veracyte report the treatment center shared with me seems complete and shows high risk. So I don't know what more the GRID would tell me, if anything?

How hard is it to get the GRID report from Veracyte. Hubby’s urologist doesn’t provide copies of the decipher or Artera.ai results. He just wrote an email and said the report came back as intermediate risk. We would love to see the actual results in print. Do you have to get permission or referral from the doctor in order for Veracyte to provide the info?

Thank you for posting your update.

I wondered a couple of things as you considered your options;
was removal ruled out?
what your urologists recommendation was?
was cribriform detected?

I am in the same boat with (3+4), 63, and have pni and cribriform. No health issues. I am weighing treatments and meet with my urology oncologists in mid-August.
Thanks.
Jon

Your husband is the patient, he definitely has a right to his report. Your urologist’s behavior would be a red flag for me.

My urologist provided a copy of what is called the “Patient Report”. It goes over the basics.

Here’s the contact info of the person who helped me get a copy of my GRID report:

Michele Abolafia , Manager Customer Experience, michele.abolafia@veracyte.com, 858.322.6129.

That was 18 months ago, so if Michele is not available I’m sure someone else can help you.

You will have to call to speak to Michele (or someone), during normal business hours, since they must send a release form, to your email address, for you to return via electronic signature.

In addition you will have to send a scanned copy of your driver's license.

That said, Michele told me she would be looking for my completed form while I was still speaking with her, which I was able to turn around in ~10 minutes.

I sent my scanned drivers license directly to her email address, along with an email address they specified....privacy is (obviously) a key concern....

Of course (hopefully), the doctor who ordered your original 3 page Decipher Report could also obtain a copy of your GRID report.

However, I would be surprised if your doctor is going to be willing to take the time to review the intricacies of your GRID report with you...again...it's research use only and contains a boatload of data.

The GRID report is a detailed 7 page report and every page has the heading "Research USE Only"...this is important to keep in mind.

Veracyte has been collecting data since 2015 and they now have >200,000 whole transcriptome tumor profiles.

Apparently the latest Decipher GRID (for Research Use Only) database uses a proprietary AI platform to compile and generate a report that is personalized and based on the genomic test results obtained from the cancer cells removed during your biopsy, as compared to all the others in their database.

In a 23 minute video (Dr. Ashley Ross, MD PhD) explains the info supplied in the Decipher GRID report (found here:

I'm still trying to understand what exactly this all may suggest...

In any case, it is undoubtably much more information than most will want to know and I'm sure most doctors will roll their eyes if you ask specific questions about the intricacies of your GRID info...but for us "data nerds" its where all this is heading regarding individualized treatment plans....for better or worse.....

All the best!!!

@jonathanack
I did not want to take the chance of some of the side effects with having my prostate removed.

My Urologist gave me two choices either prostate removal or radiation. I did a lot of research on my own as he was not great on talking about the latest and greatest in Radiation or for that matter any new technologies.

I did not have cribriform.

Private message me and I will go into mote details, if you like.

Jon: I am 66 and was 4+3 with cribriform and PNI. I did Tulsa Pro at Mayo Rochester last July. 1 year out and no sign of cancer. Very easy treatment for me and zero side effects.

Understandable!

Beside providing where one stands according to a "Clinical-Genomic" risk model (critical information if considering active surveillance), the GRID report provides information regarding the specific tumor biology "signature" of your particular form of prostate cancer.

This "signature" information helps determine whether your particular cancer cells are more or less likely to progress or have a favorable outcome, after treatment.

Your gene expression profile is also assessed as to whether it exhibits any of the more aggressive "neuroendocrine-like" disease features.

Whether your tumor is a "luminal" or "basal" subtype (luminal having a more favorable prognosis) is also ascertained. The GRID report even breakdowns, if "luminal", whether it is "differentiated" or "proliferating"; which is a measure of how receptive it would be to androgen receptor inhibition (ADT)....and all this on page 1!

There is also much more complicated analyses. "Genomic Atlas", "Gene Expression" and where your cancer cells are located on a 'Gene Expression Matrix" heat map. Your doctor is probably hoping you don't ask what these mean... remember the "Research Only" caveat....

Finally, the report provides a list of clinical trials that are pertinent for your specific form of prostate cancer.

As I indicated in another follow-up post in this thread, this may be much more than someone is interested in knowing; but its your life we are talking about and, at the very least, you may want your trusted doctor(s) to have this information to help guide their recommendations as to what treatment(s) are likely to be the best in your specific situation.

If your doctor says this information doesn't matter regarding his treatment recommendation, then all I would say is that they probably practice a "one size fits all" kind of medicine.

If that's fine with you, then leave it at that.

IMHO the future is moving to more personalized PCa treatment options, that are based on the cancer cells that are removed from your own body....but that's just me....

It definitely sounds like you are a case for active surveillance. Did you see the videos that were posted from the doctors that discuss if active surveillance is right?

Have you had an MRI of your prostate? An MRI guided biopsy assures that the spots that showed up as possibly cancerous are the spots that the samples are taken from. They only get one percent of the prostate when they do a biopsy so they can miss a lot.

Would you consider getting an expert to review your biopsy samples?. It might cost $500.