My Gleason score is 7 - 3+4. How long can I live without treatment?

Posted by mayoclinicadvice23 @mayoclinicadvice23, Jun 11, 2023

My Gleason score is 7 - 3+4,. How long can I live without treatment? Since I decided not to get any treatment, because of horrible side effects, I was wondering, if someone who experienced the same condition, will share his experience with me.

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@tdgillett

I'm 79 with 3+4 Gleason (and a 3+3) but only 2 out of 12 biopsy samples showing cancers. PSA was 7.67 October 2024 but was 4.6 in May 2025. Active surveillance for now, but the latest PSA was a (pleasant) surprise. Scheduled for another MRI and biopsy in early 2026. Anyone else have PSA declines for no apparent reason?

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I’m 61. PSA was 8.1, then 7.8 two days later than two months later 5.4 in March. Did you check your Free PSA? My MRI was PIRADS 3 with no focal lesions. Doing another PSA in June and probably another MRI if numbers go back up. Maybe a benign issue. If numbers go way up and MRI notices a change then probably biopsy.

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I had the same numbers. When my prostate was removed the cancer was not contained in the prostate.

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@dougincali

I had the same numbers. When my prostate was removed the cancer was not contained in the prostate.

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What did the MRI show before your prostate was removed?

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I have the same question. My Gleason is 3+4, and I am seriously considering observation vs. treatment. I am 70, and if I can live another 10+ years without treatment, that may be a valid option for me.
Any firsthand experience would be appreciated.

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Hi. I’ve been treating mine for 16 years starting at age 56. Now 72. Everything has side effects but I felt I can deal with it. Easier than the cancer growing and spreading.

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You really can’t just go by your Gleason score. If you had 10-12 cores positive that’s more concern than two out of 12. Family history is also to be considered. My dad and an Uncle died from it with no treatment. Years before the psa test and biopsies for prostate cancer. And if your numbers are all 3-4 that’s not as aggressive as 4-3s. Many things to be considered. All the side effects are manageable. They might not be fun, ED ect, but you can get by. If you’re 6-6 then watching is ok

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You know what the worst side effect of all is?
Being eaten alive very very slowly.

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Example and everybody is different. Mine (68 1/2 years aged) : Discovered 01/23 (scratch) 3+3=6 - started surveillance.
08/2023 second poke and hope biopsy stated benign (PSA levels continued to rise)
12/2024 third biopsy - URONAV (3d rendering with MRI) - 4+3=7 (agrresive unfavorable, 2 cores out of 12 - 40% of each core.)
Now disccussing treatment. Did not know lesion was only 5% of prostate - regardless. PSA level 11.4
04/24 - opted for RP. Pathology - cancer free. Prostate showed a small area (tiny) starting at 5 for gleason 8.
Another two years it would have spread to pelvis most likely. Advancing fairly rapid.
Now cancer free (lympth nodes, surrounding vessels, and no cancer outsideof prostate bulb.
Others go on for years and years and years sometimes before treatment and others die from something else.
Personal decision. Some cannot afford anything and travel to different countries for castration (testosterone removal). I was placed on Casodex for 2 months prior to surgery to stop the testosterone (androgen) fuel and it worked. My goal is to live forever 🙂

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