Anyone on or have taken Motegrity?

Posted by januaryjane @januaryjane, Feb 22, 2020

Anyone on or have taken Motegrity?? I am on it, 3 months, and just wanting comparisons/advice. Im taking it for stubborn CIC (slow-transit).

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beracha | @beracha | Dec 2, 2025

In reply to @maryveltema "I have taken it at least two months." + (show)

I am on it over yr and it is a miracle. I go to bathroom every day. Ibs constipation, drug induced constipation, mash.

marlenephagen | @marlenephagen | Dec 2, 2025

OTC product called MAG-07 works amazing, take before bed helps you sleep, obviously magnesium and go first thing in the morning. Available on Amazon.

bb03 | @bb03 | Dec 2, 2025

In reply to @tumblewind "After 2 months on Motegrity (generic for the past 5 weeks), I have started having bad..." + (show)

@tumblewind check your sodium and potassium. I supplement with sea salt for sodium and nu salt for potassium. I get my labs checked too. If you have kidney or heart problems check with your Dr. low sodium can cause headaches, dizziness and seizures. Mine was very low before starting supplements. Taking Linzess and miralax and magnesium citrate messes with my electrolytes.

tumblewind | @tumblewind | Dec 2, 2025

In reply to @bb03 "@tumblewind check your sodium and potassium. I supplement with sea salt for sodium and nu salt..." + (show)

@bb03 Good suggestion!

tumblewind | @tumblewind | Dec 2, 2025

In reply to @beracha "I am on it over yr and it is a miracle. I go to bathroom every..." + (show)

@beracha It stopped working for me when I changed the time of day I took it. Was taking it every morning and it worked the next morning. I heard others taking it at night so I switched to early evening. Now it hasn’t worked for a week and I’m suffering. Still taking Mag oxide & Miralax during the day. Anyone else have a similar experience with changing time they take Prucalopride (generic Motegrity) or found that the generic doesn’t work as well as brand-name Motegrity?

Janell, Volunteer Mentor | @jlharsh | Dec 2, 2025

In reply to @maryveltema "I have taken it at least two months." + (show)

Hi @maryveltema

You mention taking for a couple months.

When do you take it? What has your experience been, how is it working for you?

maryveltema | @maryveltema | Dec 2, 2025

In reply to @jlharsh "Hi @maryveltema You mention taking for a couple months. When do you take it? What has..." + (show)

I had been taking it at dinner time but my new gastroenterologist prefers
1st thing in the morning on an empty stomach.

mark1952 | @mark1952 | Dec 3, 2025

About to start Motegrity 2 mg for possible IBS-C, or CIC, or redundant colon. (Everyone here knows how murky these types of digestive issues are.) Just wondering about when to take it? Maybe at bedtime to help deal with side effects? Should I continue to take my Senna/Colace, or discontinue that? I forgot to ask my gastroenterologist, and his office is not returning calls. Thanks. Best Wishes.

Beejenigma | @beejenigma | Dec 4, 2025

I took ONE pill and got serationin syndrome! Blinding headache, vomiting, extreme dizziness, etc. I have take SSRIs before with no issues! What?! It took three days for the symptoms to go away as was lying on the couch. Never again