Anyone on or have taken Motegrity?

Posted by januaryjane @januaryjane, Feb 22, 2020

Anyone on or have taken Motegrity?? I am on it, 3 months, and just wanting comparisons/advice. Im taking it for stubborn CIC (slow-transit).

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Profile picture for shwetashah @shwetashah

Hi @jem1979 I was looking for anyone's experience with Motegrity and found this discussion. My son has "functional" GI issues, and his major issues are heartburn, bloating and dizziness. PPI and added medication caused obstinate constipation now which is not being helped by laxatives. Tried Motegrity in very small dose, helped immediately but in 4 days started causing heartburn. So I was interested in your comment about DAO helping with heartburn. Can you tell me if your heartburn was ever helped by antacids (was due to hyperacidity) or not (due to pressure reflux). My son's is pressure reflux and is probably due to the pressure from his colon (or could be SIBO/IMO so methane gas causing it). It would be very helpful if DAO helps with pressure-related heartburn.

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@shwetashah

I noticed after my colon surgery that nothing help with heartburn and my stomach pain , it felt like heartburn in my abdomen. Also constipation was horrible laxatives didn't work etc . I was diagnosed with Sibo .

I would feel great on antibiotics but once I was done with them my symptoms would return .

Long story short is my stomach is not breaking down histamines well , certain foods will trigger headaches and heartburn like symptoms, once I started treating sibo naturally and taking DAO before meals I started feeling better and have not had any significant GI issues .

For 30 dollars it's worth a shot .

Also , there were days that no matter what I took would help my heartburn or constipation, thats how I figured out it wasn't due to acidity it was an allergic reaction

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I have been on motegrity 2mg daily for 7 months now,I take it because I have generalized motility disorder,heartburn,slow digestion and chronic constipation.My GI doctor says it helps with both digestion and constipation.I started at 1mg dose and did not help much.At 2mg dose,it has helped me a lot along with pelvic therapy for 5 months and biofeedback ( I have weak rectal muscle) and Miralax daily.Fast forward to 7 months,my Dr. cut my heartburn medicine in half and cut my Miralax to every other day,dietitian helps for food guidelines too. Now I’m able to have an expanded diet though limited and go daily with just occasional constipation.I started very sick,hospitalized,only able to have liquids for 25 days and very constipated.Motegrity does cause nausea for the first 3 days every time they adjust the dose.I hope this medication helps you too.

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