MGUS with Polycythemia Vera (PV)

Posted by stljack @stljack, May 17 10:18am

Had a bone marrow biopsy done in 2017 and was diagnosed with MGUS. Additional BMBs in 2018 & 2019 showed a slow progression of my numbers. January of 2022 all my blood cell counts and hematocrit became elevated and have continued since. JAK2 test done in April came back positive. Now I have been diagnosed with PV. Is this possible? I am scheduled for another bone marrow biopsy tomorrow.

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@stljack, welcome. Fellow members like @pamdg @pennyhedgecoth @michael11750 @tlsantin @hope19 @atir @clarissa37 @chadknudson @apr931 @mwear can share more of their experiences with polycythemia vera (PV).

You can read more in this related discussion here:
– Polycythemia Vera: Just been diagnosed https://connect.mayoclinic.org/discussion/polycythemia-vera-1/

Jack, What was the result of your biopsy? Is treatment being considered?

REPLY
@colleenyoung

@stljack, welcome. Fellow members like @pamdg @pennyhedgecoth @michael11750 @tlsantin @hope19 @atir @clarissa37 @chadknudson @apr931 @mwear can share more of their experiences with polycythemia vera (PV).

You can read more in this related discussion here:
– Polycythemia Vera: Just been diagnosed https://connect.mayoclinic.org/discussion/polycythemia-vera-1/

Jack, What was the result of your biopsy? Is treatment being considered?

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Finally received the results of my BMB. Polycythemia Vera was confirmed. Additionally, my MGUS has progressed. My plasma cells have increased to 10-15% & my kappa/lambda light chain ratio is 0.05. M-spike is 2.5. I interpret this as intermediate risk smoldering myeloma. I have an appointment with my hematologist this Wednesday to discuss.
My biggest question is how common is it to have PV & MGUS (or SMM) at the same time? I assume it is better to focus on the PV and did have a phlebotomy a week ago (1 unit of blood) before the BMB. Blood tests are scheduled during my upcoming appointment. Thanks for your response.

REPLY
@stljack

Finally received the results of my BMB. Polycythemia Vera was confirmed. Additionally, my MGUS has progressed. My plasma cells have increased to 10-15% & my kappa/lambda light chain ratio is 0.05. M-spike is 2.5. I interpret this as intermediate risk smoldering myeloma. I have an appointment with my hematologist this Wednesday to discuss.
My biggest question is how common is it to have PV & MGUS (or SMM) at the same time? I assume it is better to focus on the PV and did have a phlebotomy a week ago (1 unit of blood) before the BMB. Blood tests are scheduled during my upcoming appointment. Thanks for your response.

Jump to this post

Don't know the answers to any of your questions. I have SMM too, with an M spike of 5, and but don't have the results of my cuurent labs yet. My major problem is iron deficiency anemia. I was on Methotrexate for a few years for RA and quit. It was making my anemia worse, Had to have a lot of blood transfusions. I hope that you have a really good hematologist. On FB, if you are on it there is a great group for SMM.

REPLY
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