I am trying to tough it out, but failing. I started on the Big Three six months ago but nausea was so bad after 4 months my doc stopped rifampin. Now, after two more months of mild gastrointestinal burning and cramps, I developed terrible diarhea (details intentionally not provided) and was double over with cramps. I called the office and was given permission to stop meds for two weeks until my next appt. I have a CT and sputum culture scheduled for next week. I am afraid to restart these meds. My Sjogrens has affected by GI tract and I had a similar reaction to Fosamax 2 years ago. Very discouraged.