M-Spike, High Kappa and Kappa/Lambda Ratio

Posted by Kappa King @kappaking, Mar 8 10:34pm

After experiencing chronic diarrhea for > four weeks, I decided to contact my gastro doctor. He ordered blood work and performed a colonoscopy and upper endoscopy with various biopsies. The colonoscopy, upper endoscopy and biopsies showed no sign of cancer or microscopic colitis, however the blood work showed a quite elevated IgA level. He referred me to a hematologist/oncologist who did further blood work, the results of which showed:

• Borderline low white blood count
• Borderline high red cell distribution width
• Low lymphocytes
• Low monocytes

And the most troublesome results:

• Kappa Free Light Chain Level: 290.7 mg/L, well outside of the 3.3-19.4 mg/L acceptable range
• Kappa/Lambda Ratio: 45, well outside of the .26-1.65 acceptable range
• IgA Level: 2111 mg/dL, well outside of the 70-400 mg/dL acceptable range
• IgG level of 698 mg/dL, barely outside of the 700-1660 mg/dL
• M-Spike: 1.29

There are other data points outside the reference ranges, but these are the ones that concern me most. I had been overseas when I received the results and asked my hematologist if I should cut my vacation short to come home for further evaluation/tests. He urged me not to do so and told me it can wait. I managed to enjoy my vacation but now that I returned I can't stop worrying. I'm following up with my hematologist to see what the next step is. I'm scared.

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@aczatx47131

I made a mistake.

The website for the International Myeloma Foundation is myeloma.org…not imf.org

,

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Thank you very much.

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Thank you all very much.

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@kayabbott

There is a tiny percentage of curcumin in tumeric, and it is very poorly absorbed by the body; absorption is increased by the peperine in black pepper. The peperine can irritate the GI tract in some people (me). I have IgA kappa MGUS and take 1000 mg 2x/day of bioavailable curcumin capsules. The curcumin is modified slightly to increase absorption by the GI tract and retention in ones body (by attaching a lipid [fat] to the curcumin molecules, for example}. Research suggests curcumin is useful for moderating kappa levels, although studies and results are still limited. I'm good with being a lab rat. https://pubs.acs.org/doi/10.1021/acsomega.2c07326
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881416/#:~:text=Curcumin%20is%20the%20most%20important,of%20the%20root%20(30).

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Hi @aczatx47131. Would you mind sharing the brand of turmeric with peperine Dr. Shah recommends if you know? I have been taking Pure Prescriptions Curcumin C3 Complex, but I'd like to find something a little less expensive

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@deborahjb

Hi @aczatx47131. Would you mind sharing the brand of turmeric with peperine Dr. Shah recommends if you know? I have been taking Pure Prescriptions Curcumin C3 Complex, but I'd like to find something a little less expensive

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I don’t know if she recommends a specific brand. If I recall the video correctly, she suggests 4 mg twice a day.

I eat Simply Organic brand and Spice Island brand of turmeric. Consumer Reports has tested many brands of the turmeric spice for heavy metals. These two brands are free of heavy metals.

To protect my kidneys and to lessen fatigue, I eat 9 grams of protein five or six times a day. I sprinkle turmeric on my food for each meal. Almost 3 years ago I was told my myeloma was progressing and I would need to start a new line of therapy soon. I started eating turmeric about that time. My myeloma is still progressing but very, very slowly. I have not yet started a new line of therapy.

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@deborahjb

Hi @aczatx47131. Would you mind sharing the brand of turmeric with peperine Dr. Shah recommends if you know? I have been taking Pure Prescriptions Curcumin C3 Complex, but I'd like to find something a little less expensive

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I use Qunol brand bioavailable curcumin. I don't use the tumeric (I assume you mean curcumin) with peperine. I looked at the Dr. Shah site and it is just a .com selling supplements, is pretty thin on science, and has no references. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/

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I'm scheduled for a bone marrow biopsy on April 2nd.

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@kappaking

I'm scheduled for a bone marrow biopsy on April 2nd.

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Good morning, @kappaking. There’s nothing like medical drama to overshadow a wonderful vacation. I’m glad you were able to continue the trip and not have to leave early.

Having the bone marrow biopsy should answer quite a few questions your doctor has about some of the changes in your blood numbers. The biopsy will take a sample of your marrow, which is the heart of the blood manufacturing in the body. From the detailed analysis of the samples taken, your doctor will get an overall picture of the health of your marrow and its ability to make healthy blood cells…red, white and platelets. It can take a good week or two until all the results are available.
Do you have any questions about the procedure? Will you be having sedation for this or a local anesthesia?

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@loribmt

Good morning, @kappaking. There’s nothing like medical drama to overshadow a wonderful vacation. I’m glad you were able to continue the trip and not have to leave early.

Having the bone marrow biopsy should answer quite a few questions your doctor has about some of the changes in your blood numbers. The biopsy will take a sample of your marrow, which is the heart of the blood manufacturing in the body. From the detailed analysis of the samples taken, your doctor will get an overall picture of the health of your marrow and its ability to make healthy blood cells…red, white and platelets. It can take a good week or two until all the results are available.
Do you have any questions about the procedure? Will you be having sedation for this or a local anesthesia?

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Good morning, @loribmt. Thanks for the info. I told my doctor that I wanted to be completely knocked out. He told me he can't do that unless "other arrangements" are made. I assume what he means is that it would need to be done in a hospital setting. So I'll be getting a local anesthesia. He's trying to convince me that he does many of these procedures and has never had to completely sedate a patient, and that the pain isn't all that bad. I'll just grit my teeth and hope for the best.

No questions about the procedure at the moment. My head is still swimming and spinning.

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@kappaking

Good morning, @loribmt. Thanks for the info. I told my doctor that I wanted to be completely knocked out. He told me he can't do that unless "other arrangements" are made. I assume what he means is that it would need to be done in a hospital setting. So I'll be getting a local anesthesia. He's trying to convince me that he does many of these procedures and has never had to completely sedate a patient, and that the pain isn't all that bad. I'll just grit my teeth and hope for the best.

No questions about the procedure at the moment. My head is still swimming and spinning.

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There are differing opinions on whether to be sedated or have only local anesthesia with the bone marrow biopsies. Some swear by sedation, other people are just fine without. If you have an experienced doctor who has done quite of these you’ll be in good hands.
The sample will be taken from the area on your back, just near the large dimple above your butt. You most likely won’t need a gown and from my experience, you keep your skivvies on. They will be pulled down in the back just enough to access the site. I’ve had 13 of these done and just for laughs have worn some humorous underpants to break the tension. 😅

I’m sure your head is spinning! There’s a lot of unanswered questions right now so you’re feeling very uncertain. Having a diagnosis will allow you to be able to form a plan, if needed, and to move forward. Will you let me know what you find out please?

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@loribmt

There are differing opinions on whether to be sedated or have only local anesthesia with the bone marrow biopsies. Some swear by sedation, other people are just fine without. If you have an experienced doctor who has done quite of these you’ll be in good hands.
The sample will be taken from the area on your back, just near the large dimple above your butt. You most likely won’t need a gown and from my experience, you keep your skivvies on. They will be pulled down in the back just enough to access the site. I’ve had 13 of these done and just for laughs have worn some humorous underpants to break the tension. 😅

I’m sure your head is spinning! There’s a lot of unanswered questions right now so you’re feeling very uncertain. Having a diagnosis will allow you to be able to form a plan, if needed, and to move forward. Will you let me know what you find out please?

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I absolutely will let you know. Thanks for showing interest.

To add to the stress of it all, my primary care physician - whose care I was under for over 20 years and someone I hold in the highest regard - retired last year and I haven't found a new one yet.

Then there's the issue of health insurance. I have insurance, but I think it's a bit limiting in terms of who/where I can be treated. It's insurance provided to city government workers and I fear that I'm restricted to being treated by health care professionals only in my state. So if I want to seek treatment at, say, the Mayo Clinic in Rochester, MN, I may not be covered - at least not to the extent I otherwise would be. I'll need to read the finer details of the policy. That being said, however, I live in NY where the concentration of better doctors is higher than other parts of the country.

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