Lyrica for Depression?

Posted by marjou @marjou, Aug 28 3:44pm

It has been suggested to try Lyrica for chronic depression but have noticed it being prescribed for those with pain. Would appreciate experience and side effects.

Interested in more discussions like this? Go to the Depression & Anxiety group.

@marjou, you're right. Lyrica (pregabalin) isn't typically presribed for depression. It is a medication used to treat epilepsy, neuropathic (nerve) pain, and fibromyalgia. Sometimes it may be prescribed (off label) for generalized anxiety disorder. Pregabalin works by reducing the number of pain signals that damaged nerves send out.

There are many discussions about Lyrica, especially in the neuropathy and fibromyalgia group. They are not specific to depression. You may wish to read the posts in this discussion:
– Lyrica – Looking for Patient Experiences https://connect.mayoclinic.org/discussion/lyrica-looking-for-patient-experiences/

Marjou, are you needing to switch medications? What prompted the recommendation of Lyrica for depression?

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@colleenyoung Thank you. Just got off of lorazepam which I took many years primarily for sleep and occasional anxiety. However, I noticed my sleep hasn’t improved in recent years and anxiety has gotten worse so have tried to very slowly taper off. My depression has worsened, no energy, don’t care about anything, etc. along with being medication resistant. Years ago tried Gabbapentin but side effects of shakes. Not too thrilled to try Lyrica for depression as it’s primarily for pain or fibromyalgia.
My mom is also on this awful medication (lorazepam) and has gotten worse plus has been taking it now 3 times a day…yikes. Have seen her reaction and addiction to this medication and she’s 90 years old. So my need to get off this medication.

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I find that lorazapam helps me with my anxiety but not much with depression. It can be hard to tease those two things out, but if you can it gets easier to manage the lorazapam and reduce the use of it. I take lyrica for fibro and it helps me sleep from the pain but I don’t think it does much for depression or anxiety but it does help me sleep!

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@szucker99 Have been on lorazepam for years and just tapered off very slowly. Both depression and anxiety have gotten worse and GP has suggested Lyrica which seems odd to me. Tried Gabbapentin but side effects were shakes which can be one of the side effects for Lyrica. Appreciate your input.

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@marjou

@szucker99 Have been on lorazepam for years and just tapered off very slowly. Both depression and anxiety have gotten worse and GP has suggested Lyrica which seems odd to me. Tried Gabbapentin but side effects were shakes which can be one of the side effects for Lyrica. Appreciate your input.

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Is Lyrica addicting?

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@sears

Is Lyrica addicting?

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Lyrica isn’t a narcotic if that’s what you mean. So it’s not addictive. A person would have to taper off the medication like any other, when stopping it’s use but it’s not addictive. Hope this helps!

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