Has anyone switched from Lupron to Orgovyx? Glad you did?

@jeffmarc I am having some success with a low carb diet. You might consider this.

@jeffmarc I am having some success with a low carb diet. You might consider this.

@mrd1000
I was on Lupron for six years before I switched to Orgovyx. I have noticed fewer hot flashes with orgovyx. I’ve been on Nubeqa For three years and have noticed no side effects of all from it. ADT is really what gives you the side effects. The reason studies have shown that Orgovyx Is much better for the heart than Lupron, Which can cause arteriolosclerosis Buildup that Orgovyx Doesn’t do. If you ever get off of Orgovyx Your testosterone can come back quicker.

If you are on Medicare, the maximum you will pay for drugs is $2100 a year. Between Nubeqa and Orgovyx I reached that in January, Everything’s free from then on. It is convenient to be on Orgovyx And only need to take a pill once a day. I take it in the afternoon because I take Prilosec In the morning and it conflicts with Orgovyx And can cause more side effects if you take them too close together.

They recommend getting radiation to the chest to prevent the Gynecomastia, But it is recommended you do it very early when you first start the drugs. I know people that have had breast removal surgery Due to it.

Losing weight is a real problem when you have low testosterone from ADT. It has taken me almost 4 months to lose 6 pounds. I gained during the holidays.

Some info on low T issues.

Low T causes a sluggish metabolism, reduced muscle mass, increased abdominal fat storage, and low energy for exercise. Low-T creates a cycle where weight gain further lowers testosterone, requiring lifestyle changes or medical intervention to break.

Cutting out meals for weight loss often backfires by causing your metabolism to slow down and promoting fat storage as the body enters a survival-oriented "conservation mode". It leads to nutrient deficiencies, intense hunger causing overeating later, energy crashes, mental fatigue, and potential muscle loss.

Between low T and the inability to cut out meals. It’s really annoying how hard it is for prostate cancer patientsto lose weight. When it comes down to is we really need to change our diets.

I’m 75. 3 years ago I had RALP and immediately started on ADT – Lupron. After the first shot in the butt I could hardly sit for days. Shots never bother me; maybe it was the nurse. After that I insisted in the arm, and that was no problem. Stayed on Lupron for a year. Side effects tolerable. As many people report, side effects vary drastically from one individual to the next.
After a year off of ADT, my PSA was rising, so started up again with Lupron. Did a bunch of research comparing Lupron and Orgovyx and opted to make the switch halfway through the year. My greatest reason for making the switch is that Orgovyx (relugolix) is shown to have a lower risk of major cardiovascular events that Lupron (leuprolide). Beyond that I was hoping various side effects would be better - not so, for me. I can’t wait to get off these pills very soon, and see what happens.
As to specific side effects, I find it difficult attributing them to either ADT or my multitude of old age ailments.
As to cost, I never paid a penny for Lupron, but had to pay $1180 per month until I hit my Medicare out of pocket limit.
Sorry to be so wordy.

@jeffmarc In my strength training experience prior to PC and ADT (now 3 months into Orgovyx, Abiraterone, and Prednisone), I NEVER found it conducive to weight loss. In fact, just the opposite. I gained "good" weight. So I think it's wrong to expect that our weight training, however necessary, will help much (if at all) with weight control. It's just muscle-loss damage control. For weight control, I find that I burn more calories with cardio than weights over a given workout timespan, so I'd suggest walking or running in addition to the gym. And, of course, burn more calories than you take in - your recommendation on diet is right on.

@mrd1000
I was on Lupron for six years before I switched to Orgovyx. I have noticed fewer hot flashes with orgovyx. I’ve been on Nubeqa For three years and have noticed no side effects of all from it. ADT is really what gives you the side effects. The reason studies have shown that Orgovyx Is much better for the heart than Lupron, Which can cause arteriolosclerosis Buildup that Orgovyx Doesn’t do. If you ever get off of Orgovyx Your testosterone can come back quicker.

If you are on Medicare, the maximum you will pay for drugs is $2100 a year. Between Nubeqa and Orgovyx I reached that in January, Everything’s free from then on. It is convenient to be on Orgovyx And only need to take a pill once a day. I take it in the afternoon because I take Prilosec In the morning and it conflicts with Orgovyx And can cause more side effects if you take them too close together.

They recommend getting radiation to the chest to prevent the Gynecomastia, But it is recommended you do it very early when you first start the drugs. I know people that have had breast removal surgery Due to it.

Losing weight is a real problem when you have low testosterone from ADT. It has taken me almost 4 months to lose 6 pounds. I gained during the holidays.

Some info on low T issues.

Low T causes a sluggish metabolism, reduced muscle mass, increased abdominal fat storage, and low energy for exercise. Low-T creates a cycle where weight gain further lowers testosterone, requiring lifestyle changes or medical intervention to break.

Cutting out meals for weight loss often backfires by causing your metabolism to slow down and promoting fat storage as the body enters a survival-oriented "conservation mode". It leads to nutrient deficiencies, intense hunger causing overeating later, energy crashes, mental fatigue, and potential muscle loss.

Between low T and the inability to cut out meals. It’s really annoying how hard it is for prostate cancer patientsto lose weight. When it comes down to is we really need to change our diets.

@jeffmarc GLP1s work quite well with ADTs. However, they have their own side effects, and I would never recommend anyone use them that only needed to lose 10 lbs. They also make resistance exercise more important since it is easy to lose muscle on GLP1 so you need to fight against both ADT and GLP1 to keep your muscle from wasting.

@jim18
From what I have heard people need a high BMI before a doctors will recommend GLP1. 10 pounds sure doesn’t do it.

@jeffmarc

Wegovy can be prescribed to patients who are just overweight if they have risk for cardiac disease. It is approved for that cohort of patients since it lowers risk for cardiac event via lowering inflammatory processes in the body.

Also, since PC is driven by increased BMI it can theoretically slow its progression. There are some preliminary studies done that showed better response to RT and chemo for cancer patients in general who were using GLPs - those are retrospective studies, so now they will start doing real randomized studies to see is that observation holds.