What exactly does low dose naltroxene (LDN) do for fibromyalgia?

Posted by tdinnen @tdinnen, Oct 26, 2025

What exactly does LDN do for fibromyalgia? Does it relieve pain? Depression? it sounds like it is for alcohol/drug addiction...but a lot of people have recommended it...please share how it is supposed to help, thank you
Also, does anyone have trouble with constipation???

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Profile picture for hendriksgal @hendriksgal

I am newly diagnosed for Fibro, suffered for the last 10 years the most (guessing I had it since I was 20yrs old).. making me change my whole life, leaving the job I loved of boarding and training horses for over 20 years, sold my farm and closed my business. I moved and saw drs in two states and was told I was getting "older" (turning 50) peri-meno (am not in), depression (not depressed, I'm mad at my body!) and all that. When I was diagnosed at Mayo in MN... I knew I did not want antidepressants. I researched LND and Tonmya.
I am on my 3rd week of LDN. I moved up to 3mg yesterday. I will say the 1.5 worked great for the first two weeks..it stopped all the buzzing in my body and I immediately felt better! I had to stop myself from overdoing it! When the pain is gone, the energy is back. But then I was finding it "wearing" off by 2-3pm... I would take flexeril then on bad overdoing it days.. or just motrin.
I feel alittle cloudy today on the 3mg, I'm sure its my body getting us to it.
I read people on here are starting it slowly, but my script has me to 4.5 in 3 weeks? 1 week 1.5mg, then 1 week, 3mg, and then 4.5. I hope that's not too fast? Also I hope my body doesn't get use to it too.. I guess we'll see how the 3mg works this week... cause if it works, I won't bump up yet.
I get it compounded at Avera in Sioux Falls, SD. They quoted me at 48 bucks for 30 day, 4.5mg.

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@hendriksgal I took a longer time to get to the 4.5mg dose, which was my choice. But my pharmacist advised me to take longer than three weeks. I didn't notice any positive benefits until I'd been on the maintenance dose for 1-2 months and then I had gradual improvement and today feel like I did before my symptoms flared up.

Looking back, I think I've had fibromyalgia for a long time, but it used to only flare up a couple times a year for 7-10 days, usually during the change in seasons. At that time, I thought it was the flu. Then a few years ago, it progressed to headaches, only on the left side of my head, that would last an about six weeks and then go away for about six weeks. I went to so many doctors for that and even had a biopsy of my temporal artery to rule out giant cell arteritis (GCA), which can be very serious.

When I got Covid in 2021, it triggered a major flare-up of body pain and I suffered with severe flares and terrible insomnia until I found LDN. I think it somehow triggered my immune system to get back to normal or something. I thank God every day for what seems like a miracle cure.

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Profile picture for daisy17 @daisy17

@hendriksgal I took a longer time to get to the 4.5mg dose, which was my choice. But my pharmacist advised me to take longer than three weeks. I didn't notice any positive benefits until I'd been on the maintenance dose for 1-2 months and then I had gradual improvement and today feel like I did before my symptoms flared up.

Looking back, I think I've had fibromyalgia for a long time, but it used to only flare up a couple times a year for 7-10 days, usually during the change in seasons. At that time, I thought it was the flu. Then a few years ago, it progressed to headaches, only on the left side of my head, that would last an about six weeks and then go away for about six weeks. I went to so many doctors for that and even had a biopsy of my temporal artery to rule out giant cell arteritis (GCA), which can be very serious.

When I got Covid in 2021, it triggered a major flare-up of body pain and I suffered with severe flares and terrible insomnia until I found LDN. I think it somehow triggered my immune system to get back to normal or something. I thank God every day for what seems like a miracle cure.

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@daisy17
I got covid pneumonia myself in 2020, was sick for 6 week.. I think it triggered it worst as well and its been all down hill since

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Profile picture for daisy17 @daisy17

@lena1 Please try it. It helped me very much by reducing pain and curing my insomnia. I have no bad side effects. The only problem is that you have to slowly work up to a maintenance dose so you won't experience benefits for a few months. Once you get to the maintenance dose of 4.5mg/day it can take 1-2 months to notice benefits. Also, it doesn't work for everyone, but you won't know unless you try it.

The other downside is that it's not covered by insurance and you must get it from a compounding pharmacy, where they make it in the proper doses, because it's not generally available to pharmacy's at the lower doses.

I posted this article before, there are lots of others out there can find by searching. https://chronicillness.co/low-dose-naltrexone-for-fibromyalgia/

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@daisy17 Thank you.
Iii was just told I have Hashimoto's and now, a pill for that so I am further overwhelmed because Rhuem. Dr. didn't run the full thyroid panel 2 years ago like I requested ~ only the TSH. told me I had no thyroid issues. 2 yrs. of my life untreated. He assumed it was "unnecessary"
So I feel invisible and disrespected.
If I can find a new Dr. who cares enough to listen to me; maybe I'll try the low dose LDN.

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Profile picture for lena1 @lena1

@daisy17 Thank you.
Iii was just told I have Hashimoto's and now, a pill for that so I am further overwhelmed because Rhuem. Dr. didn't run the full thyroid panel 2 years ago like I requested ~ only the TSH. told me I had no thyroid issues. 2 yrs. of my life untreated. He assumed it was "unnecessary"
So I feel invisible and disrespected.
If I can find a new Dr. who cares enough to listen to me; maybe I'll try the low dose LDN.

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@lena1
I fought for my hypothyroid diagnose too. I take Levothyroxine as well for it.
Yes they just check the basics..I went thru probably 10 doctors when I lived in Illinois. I found a great Endocrinology doctor in SD that tested everything and caught the hypo. He also diagnosed my bad gallbladder too, not in his field, when I was sent to the hospital for 14k in tests for my heart. It was a gallbladder attack... he caught it on a routine followup when I told him the issues I was having.
Look hard and Find the right dr! I saw Dr Chris Aakre at Mayo. He was excellant and very through. He took the time to look at all my past issues.. and didn't dismiss them. Toook 10 years to find the right doctors!

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Profile picture for lena1 @lena1

@daisy17 Thank you.
Iii was just told I have Hashimoto's and now, a pill for that so I am further overwhelmed because Rhuem. Dr. didn't run the full thyroid panel 2 years ago like I requested ~ only the TSH. told me I had no thyroid issues. 2 yrs. of my life untreated. He assumed it was "unnecessary"
So I feel invisible and disrespected.
If I can find a new Dr. who cares enough to listen to me; maybe I'll try the low dose LDN.

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@lena1 I also had thyroid issues start over 30 years ago. I had 1/2 of my thyroid removed then to biopsy a cyst that turned out benign. I was never told to start taking calcium so ended up with severe osteoporosis (I'm now 76). Two years ago I had parathyroid surgery and the surgeon removed my remaining thyroid because it was encased in scar tissue. I take Synthroid.

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Profile picture for hendriksgal @hendriksgal

@daisy17
I got covid pneumonia myself in 2020, was sick for 6 week.. I think it triggered it worst as well and its been all down hill since

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@hendriksgal Have you tried LDN?

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Profile picture for daisy17 @daisy17

@hendriksgal Have you tried LDN?

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@daisy17
I'm on it now. Its working great for me

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Profile picture for hendriksgal @hendriksgal

I am newly diagnosed for Fibro, suffered for the last 10 years the most (guessing I had it since I was 20yrs old).. making me change my whole life, leaving the job I loved of boarding and training horses for over 20 years, sold my farm and closed my business. I moved and saw drs in two states and was told I was getting "older" (turning 50) peri-meno (am not in), depression (not depressed, I'm mad at my body!) and all that. When I was diagnosed at Mayo in MN... I knew I did not want antidepressants. I researched LND and Tonmya.
I am on my 3rd week of LDN. I moved up to 3mg yesterday. I will say the 1.5 worked great for the first two weeks..it stopped all the buzzing in my body and I immediately felt better! I had to stop myself from overdoing it! When the pain is gone, the energy is back. But then I was finding it "wearing" off by 2-3pm... I would take flexeril then on bad overdoing it days.. or just motrin.
I feel alittle cloudy today on the 3mg, I'm sure its my body getting us to it.
I read people on here are starting it slowly, but my script has me to 4.5 in 3 weeks? 1 week 1.5mg, then 1 week, 3mg, and then 4.5. I hope that's not too fast? Also I hope my body doesn't get use to it too.. I guess we'll see how the 3mg works this week... cause if it works, I won't bump up yet.
I get it compounded at Avera in Sioux Falls, SD. They quoted me at 48 bucks for 30 day, 4.5mg.

Jump to this post

@hendriksgal The buzzing in the body! I feel that and do not know how to describe it it. It’s not a chill, not something running through my veins. Feels creepy. Sometimes just centered in my pelvic area. But that’s what it is. Buzzing. Does anyone know what causes that?

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