Long term effects AFTER withdrawing from Effexor

Posted by DissidentDaughter @dissidentdaughter, Aug 4, 2018

I am wondering if anyone has had any experience like this. I weaned off Effexor three years ago. After doing so I have gradually developed what is now becoming debilitating chronic pain. I am wondering if there is any way that being on Effexor for 15 years could have caused me to develop this pain now that I am not on it anymore. Thanks for your thoughts. I can’t seem to find any direct related research on this.

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I hope you don't mind of I chime in about supplements. I took Effexor and experienced side effects that has lasted 2 and a half years.
The side effects subsided markedly, for me at the two year period. The first major positive change occurred after ten sessions of acupuncture accompanied by ongoing counseling.
My memory and focus significantly after I started using L-thorosine. The latter was a miracle for me.
I started seeing a nurse practioner whose approach is holistic. She, unlike any of my other doctors, ran blood work. My cortisol levels were high.
I now sleep about about 85% better. I no longer wake up after experiencing what felt like being shot out of a cannon.
Diet and exercise are important. I kept overlooking this simple advise because it took so much discipline. Sugar is not a friend! Reducing it can have a major effect on reducing anxiety.
I know I gave you more than you asked.

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@henryhill

What supplements did you take to help with your withdrawal ?

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Please NOTE that I am not a doctor, or a medical professional of any kind and I'm not giving medical advice—the following is my experience and what I found helpful as I was not able to find a medical professional to help me discontinue Effexor/venlafaxine and manage/minimize the withdrawal effects. When it comes to getting off Effexor, each of us is our own guinea pig—Effexor is a very powerful antidepressant that affects the brain's neurotransmitters (serotonin and norepinephrine) and it takes your brain a while to figure out how to rebalance serotonin and norepinephrine while reducing, or after quitting Effexor.

When I started experiencing withdrawal effects back in the summer of 2018 after slowly tapering completely off Effexor, I was prescribed Valium short-term by a Care Now (walk-in health clinic) doctor when my akathisia and anxiety became overwhelming. She had me take 5mg Valium twice a day for three days straight (I stayed home from work) to "get ahead of the anxiety." Her "get ahead of it" strategy was pretty effective and she prescribed a small number of tablets to use as needed if the anxiety seemed to be building again.

I did not want to rely on Valium—I would be exchanging taking Effexor to taking a very addictive drug. I read ALL of the "Tips on minimising withdrawal symptoms from Effexor (aka Venlafaxine) discussion thread on this site to learn what others in my situation were experiencing and what was helping them and did a lot of online research re getting off drugs.
P.S. The "Tips ..." thread is now over 600 pages and it is WORTH reading every bit of it.
P.P.S. The post above by njoys has links to many helpful sites.

Through trial-and-error and research, I came up with a number of OTC medications and supplements that helped me. At first, I took these supplements five times a day; today, I am down to once per day. The most helpful are l-tryptophan (DO NOT take if you are still on Effexor) and GABA. Ben*dryl, Bon*ine, or other seasickness remedies can reduce/minimize the dizziness/vertigo and were very helpful in the beginning; I seldom need these today.

What I take daily to minimize the effects of Effexor discontinuation—
2 500 mg krill oil softgels (if you get brain zaps, fish oil may be more helpful)
2 1,000 mg Vitamin C (helps the l-tryptophan) softgels
1 500 mg l-tryptophan capsule (Lidtke brand)
1 500 mg GABA capsule (Solgar brand)
1 500 mg l-arginine capsule
1 470 mg ashwagandha root extract capsule
1 5,000 mcg Vitamin B12 (methylcobalamin) chewable tablet
Occasionally—half of 5 mg diazepam (prescription aka Valium) tablet (a few times per year)

Based on how I feel these days, I could taper off the daily dose of supplements. I have been procrastinating about doing this as as the capsule supplements don't come in smaller doses and as we know from tapering Effexor, cutting into a capsule and making smaller doses is a messy and time-consuming process. I may, instead, try waiting longer between doses—rather than taking the supplements daily, perhaps take them every day and a half; then, after a few weeks, go to every other day, etc.

Hope this helps!

REPLY
@texasduchess

Please NOTE that I am not a doctor, or a medical professional of any kind and I'm not giving medical advice—the following is my experience and what I found helpful as I was not able to find a medical professional to help me discontinue Effexor/venlafaxine and manage/minimize the withdrawal effects. When it comes to getting off Effexor, each of us is our own guinea pig—Effexor is a very powerful antidepressant that affects the brain's neurotransmitters (serotonin and norepinephrine) and it takes your brain a while to figure out how to rebalance serotonin and norepinephrine while reducing, or after quitting Effexor.

When I started experiencing withdrawal effects back in the summer of 2018 after slowly tapering completely off Effexor, I was prescribed Valium short-term by a Care Now (walk-in health clinic) doctor when my akathisia and anxiety became overwhelming. She had me take 5mg Valium twice a day for three days straight (I stayed home from work) to "get ahead of the anxiety." Her "get ahead of it" strategy was pretty effective and she prescribed a small number of tablets to use as needed if the anxiety seemed to be building again.

I did not want to rely on Valium—I would be exchanging taking Effexor to taking a very addictive drug. I read ALL of the "Tips on minimising withdrawal symptoms from Effexor (aka Venlafaxine) discussion thread on this site to learn what others in my situation were experiencing and what was helping them and did a lot of online research re getting off drugs.
P.S. The "Tips ..." thread is now over 600 pages and it is WORTH reading every bit of it.
P.P.S. The post above by njoys has links to many helpful sites.

Through trial-and-error and research, I came up with a number of OTC medications and supplements that helped me. At first, I took these supplements five times a day; today, I am down to once per day. The most helpful are l-tryptophan (DO NOT take if you are still on Effexor) and GABA. Ben*dryl, Bon*ine, or other seasickness remedies can reduce/minimize the dizziness/vertigo and were very helpful in the beginning; I seldom need these today.

What I take daily to minimize the effects of Effexor discontinuation—
2 500 mg krill oil softgels (if you get brain zaps, fish oil may be more helpful)
2 1,000 mg Vitamin C (helps the l-tryptophan) softgels
1 500 mg l-tryptophan capsule (Lidtke brand)
1 500 mg GABA capsule (Solgar brand)
1 500 mg l-arginine capsule
1 470 mg ashwagandha root extract capsule
1 5,000 mcg Vitamin B12 (methylcobalamin) chewable tablet
Occasionally—half of 5 mg diazepam (prescription aka Valium) tablet (a few times per year)

Based on how I feel these days, I could taper off the daily dose of supplements. I have been procrastinating about doing this as as the capsule supplements don't come in smaller doses and as we know from tapering Effexor, cutting into a capsule and making smaller doses is a messy and time-consuming process. I may, instead, try waiting longer between doses—rather than taking the supplements daily, perhaps take them every day and a half; then, after a few weeks, go to every other day, etc.

Hope this helps!

Jump to this post

Thank you! I started to taper off my Effexor but i couldn't do it the way my doctor suggested. ( dizziness, brain zaps, nausea, confusion, flu like symptoms)I thought I could do it between out of town trips, weddings, caymen island vacation. I think my doctor thought it would be easier too. I am going to find a psychiatrist to help with tapering dosing protocol in the future. And maybe to prescribe something that might help, like yours did. This thread about long term effects has me so concerned and a bit frightened. I wish my GP never would have put me on this! Zoloft for ten years and then 187 mg Effexor for fifteen.

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I'm on my fourth week of tapering off 150mg Effexor. I'm getting joint pain. My feet hurt almost like tendonitis but I haven't been doing repetitive/irritating movement to cause it to happen identically in both feet. My right elbow and wrist has been achy with a bit of a nerve tingle. Yesterday my left meniscus went out of joint (it did so after highschool and I thought it had ended). It's just so weird and I'm not getting actual answers as to why, so I wonder if others have experienced similar. Thanks!

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