Liver metastasis after oropharyngeal squamous cell carcinoma (OPSCC)

Posted by scottmcf1431 @scottmcf1431, Dec 13, 2025

I finished treatment for OPSCC (base of tongue + bilateral LN) 4 months ago. PET scan shows the throat cancer is gone but now I have on small metastasis on my liver and they want to start Keytruda. Does anyone have any experience with this?

Interested in more discussions like this? Go to the Head & Neck Cancer Support Group.

Hi and welcome to our group. Keytruda and other similar drugs have been used for many cancers and found to do amazing work in many cases, particularly squamous cell head and neck cancers. Long term effects are still unknown however.
Although I am not a doctor, I have observed how the medical community, against their own better judgement, assume that any cancer occurring after an initial cancer must be a metastasis of that initial cancer. Often it is not. You should ask, “How do you know this is a metastasis of the original cancer?”
Have you had a biopsy of the liver? PET scans can show all manner of things which could or could not be cancer. My PET scan will show I have lung cancer, for the last twenty years. Biopsy will show scar tissue from frosted lung fifty years ago. And I had tonsil cancer between those events. My point is, let’s not investigate cures until we know what we are really dealing with.
After our cancer battle, we always believe everything else is cancer retuning. I for one will be the first to let you know when that thought subsides.
Let’s hope for the best. And if, if this liver spot is a cancer type that Keytruda or similar drugs can combat, then we can go down that street. Good luck.

REPLY

Thanks. I have had a PET scan and a follow up MRI-CT with contrast to confirm. They seem certain that it is from my throat cancer.

REPLY
Profile picture for scottmcf1431 @scottmcf1431

Thanks. I have had a PET scan and a follow up MRI-CT with contrast to confirm. They seem certain that it is from my throat cancer.

Jump to this post

@scottmcf1431, I'm tagging other members like @kathyheidt @sepdvm @thomastunstall, who have written about living with metastatic head and neck cancer.

Have you had your follow-up appointments to learn about the treatment plan? How are you doing?

REPLY
Profile picture for Colleen Young, Connect Director @colleenyoung

@scottmcf1431, I'm tagging other members like @kathyheidt @sepdvm @thomastunstall, who have written about living with metastatic head and neck cancer.

Have you had your follow-up appointments to learn about the treatment plan? How are you doing?

Jump to this post

@colleenyoung
Thanks Colleen.

I’ve been told that I am somewhat of a “unique” case by one of the oncologists. My tumour is 1.6 cm and it is on the outside of segment 5 not near any main blood vessels of the liver. My LFT’s are very good too. He thinks there is a possibility that we could just remove it and that may be it, because he’s not 100% certain that it is a metastasis. I am waiting for the team to make a decision of whether just to excuse it or to give me a couple of months of Keytruda first just to make sure that there aren’t any other metastases. I won’t hear anything back until at least next week. Have some hope now.

REPLY
Profile picture for scottmcf1431 @scottmcf1431

@colleenyoung
Thanks Colleen.

I’ve been told that I am somewhat of a “unique” case by one of the oncologists. My tumour is 1.6 cm and it is on the outside of segment 5 not near any main blood vessels of the liver. My LFT’s are very good too. He thinks there is a possibility that we could just remove it and that may be it, because he’s not 100% certain that it is a metastasis. I am waiting for the team to make a decision of whether just to excuse it or to give me a couple of months of Keytruda first just to make sure that there aren’t any other metastases. I won’t hear anything back until at least next week. Have some hope now.

Jump to this post

@scottmcf1431, I'll be interested to hear what you find out next week. Great that there are options and hope.

REPLY
Profile picture for scottmcf1431 @scottmcf1431

@colleenyoung
Thanks Colleen.

I’ve been told that I am somewhat of a “unique” case by one of the oncologists. My tumour is 1.6 cm and it is on the outside of segment 5 not near any main blood vessels of the liver. My LFT’s are very good too. He thinks there is a possibility that we could just remove it and that may be it, because he’s not 100% certain that it is a metastasis. I am waiting for the team to make a decision of whether just to excuse it or to give me a couple of months of Keytruda first just to make sure that there aren’t any other metastases. I won’t hear anything back until at least next week. Have some hope now.

Jump to this post

@scottmcf1431 A Navdx blood test could show any cancer activity. Is this an option for you?

REPLY
Please sign in or register to post a reply.